Výsledky vyhledávání

Clinical pharmacokinetics of XP13512, a novel transported prodrug of gabapentin

Autor: Daniel M. Canafax, Wendy Luo, Joan Zou, Kenneth C. Cundy, Tristen L. Moors, Srikonda Sastry

Publikováno v: Journal of clinical pharmacology. 48(12)

Gabapentin absorption occurs in only a limited region of the small intestine and saturates at doses used clinically, resulting in dose-dependent pharmacokinetics, high interpatient variability, and potentially ineffective drug exposure. XP13512/GSK18

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f27797c4b24a794bbe56ec7ddcd348c
https://pubmed.ncbi.nlm.nih.gov/18827074

Zobrazit plný text záznamu

Akademický článek

Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin.

Autor: Cundy, Kenneth C., Sastry, Srikonda, Wendy Luo, Joan Zou, Moors, Tristen L., Canafax, Daniel M.

Publikováno v: Journal of Clinical Pharmacology; Dec2008, Vol. 48 Issue 12, p1378-1388, 11p, 5 Charts, 5 Graphs

Zobrazit plný text záznamu

Periodical

XP13512 [(+/-)-1-([(alpha-isobutanoyloxyethoxy)carbonyl] aminomethyl)-1-cyclohexane acetic acid], a novel gabapentin prodrug: II. Improved oral bioavailability, dose proportionality, and colonic absorption compared with gabapentin in rats and monkeys.

Autor: C, Cundy Kenneth, Thamil, Annamalai, Lin, Bu, Josephine, De Vera, Jenny, Estrela, Wendy, Luo, Payal, Shirsat, Allan, Torneros, Fenmei, Yao, Joan, Zou, W, Barrett Ronald, A, Gallop Mark

Publikováno v: The Journal of Pharmacology and Experimental Therapeutics; October 2004, Vol. 311 Issue: 1 p324-33, 10p

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání