Zobrazeno 1 - 10
of 96
pro vyhledávání: '"Joan, Mecsas"'
Autor:
Shuying Xu, Shumin Tan, Patricia Romanos, Jennifer L. Reedy, Yihan Zhang, Michael K. Mansour, Jatin M. Vyas, Joan Mecsas, Hongmei Mou, John M. Leong
Publikováno v:
mBio, Vol 15, Iss 9 (2024)
ABSTRACT Streptococcus pneumoniae (Sp), a leading cause of community-acquired pneumonia, can spread from the lung into the bloodstream to cause septicemia and meningitis, with a concomitant threefold increase in mortality. Limitations in vaccine effi
Externí odkaz:
https://doaj.org/article/ad03c385123a48d58ccc8fa1dd434f9d
Autor:
David Jetton, Hayley I. Muendlein, Wilson M. Connolly, Zoie Magri, Irina Smirnova, Rebecca Batorsky, Joan Mecsas, Alexei Degterev, Alexander Poltorak
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114641- (2024)
Summary: Caspase-8-dependent pyroptosis has been shown to mediate host protection from Yersinia infection. For this mode of cell death, the kinase activity of receptor-interacting protein kinase 1 (RIPK1) is required, but the autophosphorylation site
Externí odkaz:
https://doaj.org/article/8f76fc38478046edb57e8621e9f53391
Autor:
Kathleen P. Davis, Yoelkys Morales, Rachel J. Ende, Ryan Peters, Anne L. McCabe, Joan Mecsas, Bree B. Aldridge
Publikováno v:
mBio, Vol 15, Iss 3 (2024)
ABSTRACT The rise in infections caused by multidrug-resistant (MDR) bacteria has necessitated a variety of clinical approaches, including the use of antibiotic combinations. Here, we tested the hypothesis that drug-drug interactions vary in different
Externí odkaz:
https://doaj.org/article/ad83eaa2c361452087b1a4cbb17fdadd
Autor:
Giang T. Nguyen, Shuying Xu, Walter Adams, John M. Leong, Stephen C. Bunnell, Michael K. Mansour, David B. Sykes, Joan Mecsas
Publikováno v:
iScience, Vol 24, Iss 8, Pp 102871- (2021)
Summary: Signaling cascades converting the recognition of pathogens to efficient inflammatory responses by neutrophils are critical for host survival. SKAP2, an adaptor protein, is required for reactive oxygen species (ROS) generation following neutr
Externí odkaz:
https://doaj.org/article/59195d184ccc476c954222112e115428
Autor:
Alyssa C. Fasciano, Gaya S. Dasanayake, Mary K. Estes, Nicholas C. Zachos, David T. Breault, Ralph R. Isberg, Shumin Tan, Joan Mecsas
Publikováno v:
Gut Microbes, Vol 13, Iss 1 (2021)
Many pathogens use M cells to access the underlying Peyer’s patches and spread to systemic sites via the lymph as demonstrated by ligated loop murine intestinal models. However, the study of interactions between M cells and microbial pathogens has
Externí odkaz:
https://doaj.org/article/ffce43ceacb54f31bd1a2c82625cbc39
Autor:
Lamyaa Shaban, Giang T Nguyen, Benjamin D Mecsas-Faxon, Kenneth D Swanson, Shumin Tan, Joan Mecsas
Publikováno v:
PLoS Pathogens, Vol 16, Iss 5, p e1008576 (2020)
Yersinia suppress neutrophil responses by using a type 3 secretion system (T3SS) to inject 6-7 Yersinia effector proteins (Yops) effectors into their cytoplasm. YopH is a tyrosine phosphatase that causes dephosphorylation of the adaptor protein SKAP2
Externí odkaz:
https://doaj.org/article/7404841bd58143aaafafe08bb611becc
Autor:
Giang T Nguyen, Lamyaa Shaban, Matthias Mack, Kenneth D Swanson, Stephen C Bunnell, David B Sykes, Joan Mecsas
Publikováno v:
eLife, Vol 9 (2020)
Klebsiella pneumoniae is a respiratory, blood, liver, and bladder pathogen of significant clinical concern. We show that the adaptor protein, SKAP2, is required for protection against K. pneumoniae (ATCC 43816) pulmonary infections. Skap2-/- mice had
Externí odkaz:
https://doaj.org/article/e5b85fc244194d89a9dbc2b9e48796d9
Autor:
Joan Mecsas
Publikováno v:
F1000Research, Vol 8 (2019)
The human and animal pathogens Yersinia pestis, which causes bubonic and pneumonic plague, and Yersinia pseudotuberculosis and Yersinia enterocolitica, which cause gastroenteritis, share a type 3 secretion system which injects effector proteins, Yops
Externí odkaz:
https://doaj.org/article/6b75a81b17ae46d2b10bcfdfa97f81e5
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 7 (2017)
Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent and severe bacterial infections, while their unregulated release leads to
Externí odkaz:
https://doaj.org/article/d23557e6790d4ec195a9ac7cd372cec6
The rise in infections caused by multidrug-resistant (MDR) bacteria has necessitated a variety of clinical approaches, including the use of antibiotic combinations. Antibiotic susceptibility is affected in part by the growth state of bacteria within
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b8f0dffeffed60b2813bc5e23ed93b8f
https://doi.org/10.1101/2022.09.20.508761
https://doi.org/10.1101/2022.09.20.508761
