Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging.

Autor: W Edward Visser, Cíntia R Bombardieri, Chantal Zevenbergen, Sander Barnhoorn, Alexandre Ottaviani, Ingrid van der Pluijm, Renata Brandt, Ellen Kaptein, Ramona van Heerebeek, Hans van Toor, George A Garinis, Robin P Peeters, Marco Medici, Willy van Ham, Wilbert P Vermeij, Monique C de Waard, Ronald R de Krijger, Anita Boelen, Joan Kwakkel, John J Kopchick, Edward O List, Joost P M Melis, Veerle M Darras, Martijn E T Dollé, Gijsbertus T J van der Horst, Jan H J Hoeijmakers, Theo J Visser

Publikováno v: PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of

Externí odkaz: https://doaj.org/article/ca420b0d4f254e4db9aa43c0a8d08565

Tissue thyroid hormone metabolism is differentially regulated during illness in mice

Autor: Anne H van der Spek, Emmely M de Vries, Olga V. Surovtseva, Mieke van Beeren, Anita Boelen, Mariëtte T. Ackermans, Flavia Fonseca Bloise, Eric Fliers, Joan Kwakkel

Publikováno v: Journal of endocrinology, 233(1), 25-36. Society for Endocrinology

Illness induces major modifications in central and peripheral thyroid hormone (TH) metabolism, so-called nonthyroidal illness syndrome (NTIS). As a result, organ-specific changes in local TH availability occur depending on the type and severity of il

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::336055e11fc31a8cf9fad32ef170154b
https://pure.amc.nl/en/publications/tissue-thyroid-hormone-metabolism-is-differentially-regulated-during-illness-in-mice(7b19a981-df52-4e94-9d44-289868aca785).html

A Novel Role for the Thyroid Hormone-Activating Enzyme Type 2 Deiodinase in the Inflammatory Response of Macrophages

Autor: Ellen A. Fliers, Olga V. Surovtseva, Anita Boelen, J. Stap, E. M. de Vries, Joan Kwakkel

Publikováno v: Endocrinology, 155(7), 2725-2734. The Endocrine Society

Deiodinase type 2 (D2) is a thyroid hormone-activating enzyme converting the prohormone T-4 into the active hormone T-3. In the present study, we show for the first time that D2 is up-regulated in the mouse liver during acute and chronic inflammation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c3e8a9591abed4f781df60806db8f00
https://doi.org/10.1210/en.2013-2066

Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging

Autor: George A. Garinis, Veerle Darras, Robin P. Peeters, Hans van Toor, Ramona van Heerebeek, Martijn E.T. Dollé, Anita Boelen, Sander Barnhoorn, Joan Kwakkel, Renata M. C. Brandt, John J. Kopchick, Joost P.M. Melis, W. Edward Visser, Ellen Kaptein, Edward O. List, Theo J. Visser, Marco Medici, Ingrid van der Pluijm, Wilbert P. Vermeij, Alexandre Ottaviani, Gijsbertus T. J. van der Horst, Monique C. de Waard, Jan H.J. Hoeijmakers, Ronald R. de Krijger, Willy van Ham, Cíntia R. Bombardieri, Chantal Zevenbergen

Publikováno v: PLoS ONE, 11(3). Public Library of Science
PLoS ONE, 11(3):e0149941. Public Library of Science
PLoS ONE
PLoS One (print), 11(3). Public Library of Science
PLoS ONE, Vol 11, Iss 3, p e0149941 (2016)
Visser, W E, Bombardieri, C R, Zevenbergen, C, Barnhoorn, S, Ottaviani, A, van der Pluijm, I, Brandt, R, Kaptein, E, van Heerebeek, R, van Toor, H, Garinis, G A, Peeters, R P, Medici, M, van Ham, W, Vermeij, W P, de Waard, M C, de Krijger, R R, Boelen, A, Kwakkel, J, Kopchick, J J, List, E O, Melis, J P M, Darras, V M, Dolle, M E T, van der Horst, G T J, Hoeijmakers, J H J & Visser, T J 2016, ' Tissue-Specific Suppression of Thyroid Hormone Signaling in Various Mouse Models of Aging ', PLoS ONE, vol. 11, no. 3, e0149941 . https://doi.org/10.1371/journal.pone.0149941
PLoS ONE [E], 11(3). Public Library of Science

DNA damage contributes to the process of aging, as underscored by premature aging syndromes caused by defective DNA repair. Thyroid state changes during aging, but underlying mechanisms remain elusive. Since thyroid hormone (TH) is a key regulator of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3465e40b38ba3ad51d1337376ee538f7
https://doi.org/10.1371/journal.pone.0149941

Leptin Administration Restores the Fasting-Induced Increase of Hepatic Type 3 Deiodinase Expression in Mice

Autor: Xander Vos, Evita Belegri, Andries Kalsbeek, Eric Fliers, Joan Kwakkel, Olga V. Surovtseva, Anita Boelen, Erno Vreugdenhil, Dirk-Jan Saaltink, Mieke van Beeren

Publikováno v: Thyroid, 22, 192-199. Mary Ann Liebert Inc.
Thyroid, 22(2), 192-199. Mary Ann Liebert Inc.

Background: Decreased serum leptin has been proposed as a critical signal initiating the neuroendocrine response to fasting. Leptin administration partially reverses the fasting-induced suppression of the hypothalamus-pituitary-thyroid axis at the ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f152a683df239d124a2863330a846ce1
https://doi.org/10.1089/thy.2011.0289