Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Joakim E Swedberg"'
Autor:
Xingchen Chen, Blake T Riley, Simon J de Veer, David E Hoke, Jessica Van Haeften, Darren Leahy, Joakim E Swedberg, Maria Brattsand, Perry J Hartfield, Ashley M Buckle, Jonathan M Harris
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0210842 (2019)
Engagement of an extended β-sheet is a common substrate/inhibitor interaction at the active site of serine proteases and is an important feature of Laskowski mechanism inhibitors that present a substrate-like loop to a target protease. This loop is
Externí odkaz:
https://doaj.org/article/ff0580b312cb47f5b9a6eca710bfcd0a
Autor:
Ying Dong, Carson Stephens, Carina Walpole, Joakim E Swedberg, Glen M Boyle, Peter G Parsons, Michael A McGuckin, Jonathan M Harris, Judith A Clements
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e57056 (2013)
High tumor kallikrein-related-peptidase 4 (KLK4) levels are associated with a poor outcome for women with serous epithelial ovarian cancer (EOC), for which peritoneal dissemination and chemoresistance are key events. To determine the role of KLK4 in
Externí odkaz:
https://doaj.org/article/df613d512bcb483f96345a9caeb7477b
Autor:
Joakim E Swedberg, Simon J de Veer, Kei C Sit, Cyril F Reboul, Ashley M Buckle, Jonathan M Harris
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19302 (2011)
BACKGROUND: Canonical serine protease inhibitors commonly bind to their targets through a rigid loop stabilised by an internal hydrogen bond network and disulfide bond(s). The smallest of these is sunflower trypsin inhibitor (SFTI-1), a potent and br
Externí odkaz:
https://doaj.org/article/50c0a0c2cf3449b7b64f8c36d6b93a8a
An Ultrapotent and Selective Cyclic Peptide Inhibitor of Human β-Factor XIIa in a Cyclotide Scaffold
Autor:
Christina N. Zdenek, Simon J. de Veer, Hiroaki Suga, Bryan G. Fry, Toby Passioura, Joakim E. Swedberg, Wenyu Liu, Chikako Okada, David J. Craik, Toru Sengoku, Kazuhiro Ogata, Yen-Hua Huang
Publikováno v:
Journal of the American Chemical Society. 143:18481-18489
Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail cyclic backbone and cystine knot core. These structural features underpin the native bioactivities of cyclotides, as well as their beneficial properties as pha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a65f8762d7ad0988885822cbd6f90e
https://doi.org/10.1021/jacs.1c07574
https://doi.org/10.1021/jacs.1c07574
Autor:
Gordon J. King, David J. Craik, Kuok Yap, Andrew M. White, Peta J. Harvey, Guojie Wu, Ruby H. P. Law, Simon J. de Veer, Joakim E. Swedberg, Conan K. Wang, Thomas Durek
Publikováno v:
Angewandte Chemie International Edition. 59:11273-11277
Ruthenium-catalysed azide-alkyne cycloaddition (RuAAC) provides access to 1,5-disubstituted 1,2,3-triazole motifs in peptide engineering applications. However, investigation of this motif as a disulfide mimetic in cyclic peptides has been limited, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd06b0ba14d993b3cbfff990fda8f9d
https://doi.org/10.1002/anie.202003435
https://doi.org/10.1002/anie.202003435
Autor:
Simon J. de Veer, Choi Yi Li, Joakim E. Swedberg, Jonathan M. Harris, Xingchen Chen, David J. Craik, Andrew M. White
Publikováno v:
Journal of Medicinal Chemistry. 62:3696-3706
Sunflower trypsin inhibitor-1 (SFTI-1) is a 14-amino acid cyclic peptide that shares an inhibitory loop with a sequence and structure similar to a larger family of serine protease inhibitors, the Bowman-Birk inhibitors. Here, we focus on the P5' resi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbd8411c43991d11952452cd329ad373
https://doi.org/10.1021/acs.jmedchem.9b00211
https://doi.org/10.1021/acs.jmedchem.9b00211
Autor:
Joakim E. Swedberg, David J. Craik, Ruby H. P. Law, Thomas Durek, Tunjung Mahatmanto, Tom T. Caradoc-Davies, Guojie Wu, James C. Whisstock
Publikováno v:
Journal of Medicinal Chemistry. 62:552-560
Antifibrinolytic drugs provide important pharmacological interventions to reduce morbidity and mortality from excessive bleeding during surgery and after trauma. Current drugs used for inhibiting the dissolution of fibrin, the main structural compone
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c25cdcc5b559f0023a0d2f92259a4bd9
https://doi.org/10.1021/acs.jmedchem.8b01139
https://doi.org/10.1021/acs.jmedchem.8b01139
Publikováno v:
ACS Medicinal Chemistry Letters. 9:1258-1262
[Image: see text] Kallikrein-related peptidase 4 (KLK4) is a serine protease that has putative intracellular and extracellular functions in prostate cancer progression. Here we show that MCoTI-II, a 34-amino acid cyclic peptide found in the seeds of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd4b5250a80e1deb1737e1ddd83deee6
https://doi.org/10.1021/acsmedchemlett.8b00422
https://doi.org/10.1021/acsmedchemlett.8b00422
Publikováno v:
European Journal of Medicinal Chemistry. 155:695-704
Plants produce a diverse range of peptides and proteins that inhibit the activity of different serine proteases. The value of these inhibitors not only stems from their native role(s) in planta, but they are also regarded as promising templates for i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fc86e5a734e2c92acc2f45ad5eb93f8
https://doi.org/10.1016/j.ejmech.2018.06.029
https://doi.org/10.1016/j.ejmech.2018.06.029
Publikováno v:
The Journal of Physical Chemistry B. 122:2261-2276
Several cyclic peptides have been reported to have unexpectedly high membrane permeability. Of these, cyclosporin A is perhaps the most well-known example, particularly in light of its relatively high molecular weight. Observations that cyclosporin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89cc747bf6d9d8358e815c9b8261201d
https://doi.org/10.1021/acs.jpcb.7b12419
https://doi.org/10.1021/acs.jpcb.7b12419