A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo.

Autor: Nidhi Gupta, Niels Fisker, Marie-Claude Asselin, Marie Lindholm, Christoph Rosenbohm, Henrik Ørum, Joacim Elmén, Nabil G Seidah, Ellen Marie Straarup

Publikováno v: PLoS ONE, Vol 5, Iss 5, p e10682 (2010)

The proprotein convertase subtilisin/kexin type 9 (PCSK9) is an important factor in the etiology of familial hypercholesterolemia (FH) and is also an attractive therapeutic target to reduce low density lipoprotein (LDL) cholesterol. PCSK9 accelerates

Externí odkaz: https://doaj.org/article/19e6140d8bba4fac8a55f564acd212c1

MicroRNA-219 modulates NMDA receptor-mediated neurobehavioral dysfunction

Autor: Jia Huang, Nicole Salès, Amy J. Ramsey, Mohammad Ali Faghihi, Marc G. Caron, Henrik Frydenlund Hansen, Joacim Elmén, Sakari Kauppinen, Paul J. Kenny, David Willoughby, Miguel A. Lopez-Toledano, Henrik Ørum, Jannet Kocerha, Claes Wahlestedt

Publikováno v: Proceedings of the National Academy of Sciences. 106:3507-3512

N -methyl- d -aspartate (NMDA) glutamate receptors are regulators of fast neurotransmission and synaptic plasticity in the brain. Disruption of NMDA-mediated glutamate signaling has been linked to behavioral deficits displayed in psychiatric disorder

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c24187694f208e0a7f30d097cab81235
https://doi.org/10.1073/pnas.0805854106

Kinetics of toluene degradation by a nitrate-reducing bacterium isolated from a groundwater aquifer

Autor: So Yan Leung, Wubin Pan, Joacim Elmén, Jay D. Keasling, Andrew C. Magyarosy

Publikováno v: Biotechnology and Bioengineering. 55:82-90

Groundwater from a xylene-contaminated aquifer was enriched in the laboratory in the presence of toluene, xylenes, ethylbenzene, and benzene. A pure culture that degrades toluene and m-xylene under nitrate-reducing conditions was isolated. Fatty acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9ee2ee64fc68a47ac6104d33fba0a3a7
https://doi.org/10.1002/(sici)1097-0290(19970705)55:1<82::aid-bit10>3.0.co

The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice

Autor: Maja Vujić Spasić, Jens Stolte, Thomas Longerich, Robert E. Fleming, Martina U. Muckenthaler, Mirco Castoldi, Sakari Kauppinen, Ursula Klingmüller, Matthias W. Hentze, Sandro Altamura, Hermann J. Gröne, Joacim Elmén, Lorenza A. D'Alessandro, Judit Kiss, Richard Sparla, Vladimir Benes, Morten Lindow

Publikováno v: Castoldi, M, Spasic, M V, Altamura, S, Elmén, J, Lindow, M, Kiss, J, Stolte, J, Sparla, R, D'Alessandro, L A, Klingmüller, U, Fleming, R E, Longerich, T, Gröne, H J, Benes, V, Kauppinen, S, Hentze, M W & Muckenthaler, M U 2011, ' The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice ', Journal of Clinical Investigation, vol. 121, no. 4, pp. 1386-1396 . https://doi.org/10.1172/JCI44883

Systemic iron homeostasis is mainly controlled by the liver through synthesis of the peptide hormone hepcidin (encoded by Hamp), the key regulator of duodenal iron absorption and macrophage iron release. Here we show that the liver-specific microRNA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::918951f5af0d8feca73779875a3656fe
https://europepmc.org/articles/PMC3069782/

Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver

Autor: Keith Mccullagh, Mette Christensen, Jens Bo Hansen, Sakari Kauppinen, Ellen Marie Straarup, Phil Kearney, Maj Hedtjärn, Allan Lind-Thomsen, Joacim Elmén, Mads Bak, Henrik Hansen, Asli Silahtaroglu, Morten Lindow

Publikováno v: Elmen, J, Lindow, M, Silahtaroglu, A, Bak, M, Christensen, M, Lind-Thomsen, A, Hedtjarn, M, hansen, J B, Hansen, H F, Straarup, E M, McCullagh, K, Keraney, P & Kauppinen, M S 2008, ' Antagonism of microRNA-122 in mice by systemically administered LNA-antimiR leads to up-regulation of a large set of predicted target mRNAs in the liver ', Nucleic Acids Research, vol. 36, no. 4, pp. 1153-1162 . https://doi.org/PMID: 1815830410.1093/nar/gkm1113
Nucleic Acids Research

Udgivelsesdato: 2008 Mar MicroRNA-122 (miR-122) is an abundant liver-specific miRNA, implicated in fatty acid and cholesterol metabolism as well as hepatitis C viral replication. Here, we report that a systemically administered 16-nt, unconjugated LN

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::737501d926db11e92f89c35ab23bf06a
https://curis.ku.dk/ws/files/10189260/1153.pdf