Zobrazeno 1 - 10
of 318
pro vyhledávání: '"Joachim P Steinbach"'
Autor:
Lukas Bunse, Anne-Kathleen Rupp, Isabel Poschke, Theresa Bunse, Katharina Lindner, Antje Wick, Jens Blobner, Martin Misch, Ghazaleh Tabatabai, Martin Glas, Oliver Schnell, Jens Gempt, Monika Denk, Guido Reifenberger, Martin Bendszus, Patrick Wuchter, Joachim P Steinbach, Wolfgang Wick, Michael Platten
Publikováno v:
Neurological Research and Practice, Vol 4, Iss 1, Pp 1-7 (2022)
Abstract Introduction Isocitrate dehydrogenase (IDH) mutations are disease-defining mutations in IDH-mutant astrocytomas and IDH-mutant and 1p/19q-codeleted oligodendrogliomas. In more than 80% of these tumors, point mutations in IDH type 1 (IDH1) le
Externí odkaz:
https://doaj.org/article/4c9969cb47df44d0813e1eae513b7e2a
Autor:
Alexander Scholz, Patrick N Harter, Sebastian Cremer, Burak H Yalcin, Stefanie Gurnik, Maiko Yamaji, Mariangela Di Tacchio, Kathleen Sommer, Peter Baumgarten, Oliver Bähr, Joachim P Steinbach, Jörg Trojan, Martin Glas, Ulrich Herrlinger, Dietmar Krex, Matthias Meinhardt, Astrid Weyerbrock, Marco Timmer, Roland Goldbrunner, Martina Deckert, Christian Braun, Jens Schittenhelm, Jochen T Frueh, Evelyn Ullrich, Michel Mittelbronn, Karl H Plate, Yvonne Reiss
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 1, Pp 39-57 (2015)
Abstract Glioblastoma multiforme (GBM) is treated by surgical resection followed by radiochemotherapy. Bevacizumab is commonly deployed for anti‐angiogenic therapy of recurrent GBM; however, innate immune cells have been identified as instigators o
Externí odkaz:
https://doaj.org/article/af8368e7b96a49249d7c2629d25736da
Autor:
Michael C Burger, Pia S Zeiner, Kolja Jahnke, Marlies Wagner, Michel Mittelbronn, Joachim P Steinbach
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0155315 (2016)
Leptomeningeal dissemination of a primary brain tumor is a condition which is challenging to treat, as it often occurs in rather late disease stages in highly pretreated patients. Its prognosis is dismal and there is still no accepted standard of car
Externí odkaz:
https://doaj.org/article/d100c00143bd42b287f140534515adba
Autor:
Eike Steidl, Ulrich Pilatus, Elke Hattingen, Joachim P Steinbach, Friedhelm Zanella, Michael W Ronellenfitsch, Oliver Bähr
Publikováno v:
PLoS ONE, Vol 11, Iss 12, p e0168113 (2016)
Antiangiogenic treatment of glioblastomas with Bevacizumab lacks predictive markers. Myoinositol (MI) is an organic osmolyte, with intracellular concentration changes depending on the extracellular osmolality. Since Bevacizumab markedly reduces tumor
Externí odkaz:
https://doaj.org/article/b6a7518ef840491ca8b58500c5da4d12
Autor:
Patrick N Harter, Lukas Jennewein, Peter Baumgarten, Elena Ilina, Michael C Burger, Anna-Luisa Thiepold, Julia Tichy, Martin Zörnig, Christian Senft, Joachim P Steinbach, Michel Mittelbronn, Michael W Ronellenfitsch
Publikováno v:
PLoS ONE, Vol 10, Iss 5, p e0127123 (2015)
Current pathological diagnostics include the analysis of (epi-)genetic alterations as well as oncogenic pathways. Deregulated mammalian target of rapamycin complex 1 (mTORC1) signaling has been implicated in a variety of cancers including malignant g
Externí odkaz:
https://doaj.org/article/9d545b75c567496b8ede51c49eb4ed0f
Autor:
Patrick N Harter, Jenny Zinke, Alexander Scholz, Julia Tichy, Cornelia Zachskorn, Hans M Kvasnicka, Benjamin Goeppert, Céline Delloye-Bourgeois, Elke Hattingen, Christian Senft, Joachim P Steinbach, Karl H Plate, Patrick Mehlen, Dorothea Schulte, Michel Mittelbronn
Publikováno v:
PLoS ONE, Vol 9, Iss 3, p e92311 (2014)
The multifunctional molecule netrin-1 is upregulated in various malignancies and has recently been presented as a major general player in tumorigenesis leading to tumor progression and maintenance in various animal models. However, there is still a l
Externí odkaz:
https://doaj.org/article/02239f747ee44b2a98086e30e7b0add9
Autor:
Sebastian Fischer, Michael W Ronellenfitsch, Anna-Luisa Thiepold, Patrick N Harter, Sebastian Reichert, Donat Kögel, Reinhard Paschke, Michel Mittelbronn, Michael Weller, Joachim P Steinbach, Simone Fulda, Oliver Bähr
Publikováno v:
PLoS ONE, Vol 9, Iss 4, p e94921 (2014)
B10 is a glycosylated derivative of betulinic acid with promising activity against glioma cells. Lysosomal cell death pathways appear to be essential for its cytotoxicity. We investigated the influence of hypoxia, nutrient deprivation and current sta
Externí odkaz:
https://doaj.org/article/39b7983e9ddb49daa4781628c107e7a8
Autor:
Sophie von Brauchitsch, Adam Strzelczyk, Felix Rosenow, Elisabeth Neuhaus, Daniel Dubinski, Joachim P. Steinbach, Martin Voss
Publikováno v:
Journal of Neuro-Oncology. 160:277-284
Purpose Seizures pose a significant burden in patients with primary and secondary brain tumors during the end-of-life period. A wide range of 6 to 56% of clinically observed epileptic seizures at the end of life has been reported. We aimed to analyse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8e6d4bb7320131887753531c22df167
https://doi.org/10.1007/s11060-022-04133-1
https://doi.org/10.1007/s11060-022-04133-1
Autor:
Makoto Kiyose, Eva Herrmann, Jenny Roesler, Pia S. Zeiner, Joachim P. Steinbach, Marie-Therese Forster, Karl H. Plate, Marcus Czabanka, Thomas J. Vogl, Elke Hattingen, Michel Mittelbronn, Stella Breuer, Patrick N. Harter, Simon Bernatz
Publikováno v:
Neuroradiology. 65:275-285
Purpose Non-invasive prediction of the tumour of origin giving rise to brain metastases (BMs) using MRI measurements obtained in radiological routine and elucidating the biological basis by matched histopathological analysis. Methods Preoperative MRI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107212a852a4a4cd747cbe95265e44ec
https://doi.org/10.1007/s00234-022-03060-2
https://doi.org/10.1007/s00234-022-03060-2
Molecular matched targeted therapies for primary brain tumors—a single center retrospective analysis
Autor:
Anna-Luisa Luger, Sven König, Patrick Felix Samp, Hans Urban, Iris Divé, Michael C. Burger, Martin Voss, Kea Franz, Emmanouil Fokas, Katharina Filipski, Melanie-Christin Demes, Albrecht Stenzinger, Felix Sahm, David E. Reuss, Patrick N. Harter, Sebastian Wagner, Elke Hattingen, Jennifer Wichert, Constantin Lapa, Stefan Fröhling, Joachim P. Steinbach, Michael W. Ronellenfitsch
Publikováno v:
Journal of Neuro-Oncology. 159:243-259
Purpose Molecular diagnostics including next generation gene sequencing are increasingly used to determine options for individualized therapies in brain tumor patients. We aimed to evaluate the decision-making process of molecular targeted therapies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5089ac8b95ae7051eef926341832d6d1
https://doi.org/10.1007/s11060-022-04049-w
https://doi.org/10.1007/s11060-022-04049-w