Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joachim Nozulak"'
Autor:
Herbert Mühle, Joachim Nozulak, Jacques Cercus, Ernst Küsters, Ulrich Beutler, Gerhard Penn, Werner Zaugg
Publikováno v:
CHIMIA, Vol 50, Iss 5 (1996)
cis-4,5,7a,8,9,10,11,11a-Octahydro-7H-10-methylindolo[1,7-bc][2,6]naphthyridine (rac-4) (SDZ SER-082) is a selective and potent 5-HT2C/2B receptor antagonist, exerting weak affinity towards the 5-HT2A receptor site. The compound 4 was found to be a
Externí odkaz:
https://doaj.org/article/24902d95c9ae4a5a82a9b258e18f8a68
Autor:
Joachim Nozulak, Klemens Kaupmann, Reiner Aichholz, Samuel Hintermann, Joachim Blanz, Johannes Mosbacher, Konstanze Hurth, Marina Tintelnot-Blomley
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:1523-1526
A novel series of agonists at the benzodiazepine binding site of the GABAA receptor was prepared by functionalizing a known template. Adding substituents to the pyrazolone-oxygen of CGS-9896 led to a number of compounds with selectivities for either
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05cd6fb8c518d6565fc67d6b454e58c3
https://doi.org/10.1016/j.bmcl.2010.12.107
https://doi.org/10.1016/j.bmcl.2010.12.107
Autor:
Christoph Züger, Hendrik Andres, Peter Schnelli, Rhys Salter, P. Burtscher, Thomas Moenius, Tapan Ray, Rolf Voges, Joachim Nozulak
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 50:616-619
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7acb36cbff1cfa30a1cc4ae2513c6273
https://doi.org/10.1002/jlcr.1310
https://doi.org/10.1002/jlcr.1310
Autor:
Anja Weber, Dominik Feuerbach, Rémy Longato, Rochdi Bouhelal, Sandra Michelmore, Daniel Hoyer, Kim Croskery, Joachim Nozulak
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 366:235-245
In this study three major subtypes of nicotinic acetylcholine receptors were characterized pharmacologically using the calcium influx through the ion channel as a robust functional assay system. Human α3β4 receptors and α4β2 receptors were cloned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e5e96313c202d569eac91a3f9b7817c5
https://doi.org/10.1007/s00210-002-0589-z
https://doi.org/10.1007/s00210-002-0589-z
Autor:
J R Jones, S-Y Lu, V. P. Shevchenko, I. Yu. Nagaev, N. F. Myasoedov, A. B. Susan, R. Anderskerskevitz, F. W. Birke, K-H. Switek, Peter Wiegerinck, Olaf Post, Leontine Hofstede, Marcel van den Heuvel, U. Pleiss, D. Seidel, K.-H. Switek, H. Braunger, Dietrich Seidel, Rainer Schlecker, Thomas Moenius, Max-Peter Seiler, Joachim Nozulak, Paul Burtscher, Mario Almi, Simone Guelfi, Maria Luisa Navacchia, C. Felicini, D. Giribone, A. Pignatti, E. Fontana, J. W. McGrath, B. Peric Simov, W. Preusser, J. P. Quinn, S. Schmidt, A. Woschek, F. Wuggenig, F. Hammerschmidt, H. Spies, Jochen Maas, Volker Krone, Frank Diehl, Johannes Coy, J�rg Hoheisel, Magnus von Knebel Doeberitz, Matthias Nees, Alfred Klett
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 45:1159-1198
Title Author(s) Tetramethylammonium Tri-acetoxyborotritide, a Reagent for Hydroxy-directed Ketone Reduction H. Andres Synthesis of Tritium-labeled Nucleosides with Anti-HIV and Anticancer Activity G.V. Sidorov, Yu.B. Zverkov, N.F. Myasoedov, A.R. Cim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::04ce5f4df1cb1aad0a0e4853b5347144
https://doi.org/10.1002/jlcr.658
https://doi.org/10.1002/jlcr.658
Publikováno v:
European Journal of Pharmacology. 343:201-207
5-HT receptor antagonists with selectivity for 5-HT 1A WAY-100635 ( N -[2-[-(2-methoxyphenyl)-1-piperazinyl]ethyl]- N -(2-pyridinyl)cyclohexanecarboxamide), 5-HT 1B GR 127935 ( N -[methoxy-3-(4-methyl-1-piperazinyl)phenyl]-2′-methyl-4′(5-methyl-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aea8c224e2d948dc8f88ee58b802e3fc
https://doi.org/10.1016/s0014-2999(97)01554-9
https://doi.org/10.1016/s0014-2999(97)01554-9
Autor:
David Orain, Philipp Floersheim, Sandrine Desrayaud, Silvio Ofner, Manuel Koller, Stephan Urwyler, David Carcache, Nicolas Soldermann, Hans Allgeier, Henri Mattes, Joerg Kallen, Kurt Lingenhoehl, Wolfgang Froestl, Vittorio Rasetti, Joachim Nozulak
Publikováno v:
Bioorganicmedicinal chemistry letters. 22(2)
A new set of quinazolinedione sulfonamide derivatives as competitive AMPA receptor antagonist with improved properties compared to 1 is disclosed. By modulating physico-chemical properties, compound 29 was identified with a low ED 50 of 5.5 mg/kg in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3386f710bea803b7f77b2bb38566fecb
https://pubmed.ncbi.nlm.nih.gov/22197388
https://pubmed.ncbi.nlm.nih.gov/22197388
Autor:
Konstanze Hurth, Mathias Frederiksen, Albert Enz, Dominik Feuerbach, Bernard Lucien Roy, Werner Müller, Joachim Nozulak, Conrad Gentsch
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(5)
A novel class of alpha7 nicotinic acetylcholine receptor (nAChR) agonists has been discovered through high-throughput screening. The cis gamma-lactam scaffold has been optimized to reveal highly potent and selective alpha7 nAChR agonists with in vitr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4791ac26330d3e9d3ca5994553cced8d
https://pubmed.ncbi.nlm.nih.gov/19208472
https://pubmed.ncbi.nlm.nih.gov/19208472
Autor:
Dominik Feuerbach, Graeme Bilbe, Joachim Nozulak, Frederique Chaperon, Daniel Hoyer, Annick Vassout, Kurt Lingenhoehl, Conrad Gentsch, Albert Enz, Hans-Rudolf Olpe, Kevin H. McAllister
Publikováno v:
Neuropharmacology. 56(1)
Several lines of evidence suggest that the nicotinic acetylcholine receptor alpha7 (nAChR alpha7) is involved in central nervous system disorders like schizophrenia and Alzheimer's disease as well as in inflammatory disorders like sepsis and pancreat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9dfe7de9f0c8fceeecddb44321b14287
https://pubmed.ncbi.nlm.nih.gov/18793655
https://pubmed.ncbi.nlm.nih.gov/18793655
Autor:
John F. Cryan, Kevin H. McAllister, Natacha Stoehr, Rainer Kuhn, Cedric Mombereau, Peter J. Flor, Oliver L. Pescott, Silvio Ofner, Joachim Nozulak, K Mitsukawa, Rina Yamamoto, Snezana Lukic, P. Herman van der Putten
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 102(51)
Metabotropic glutamate receptor (mGluR) subtypes (mGluR1 to mGluR8) act as important pre- and postsynaptic regulators of neurotransmission in the CNS. These receptors consist of two domains, an extracellular region containing the orthosteric agonist
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21ab64afa3f751e7636d8bcbf80a7e7c
https://pubmed.ncbi.nlm.nih.gov/16407154
https://pubmed.ncbi.nlm.nih.gov/16407154