Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Joachim Nickel"'
Autor:
Claudia Siverino, Shorouk Fahmy-Garcia, Viktoria Niklaus, Nicole Kops, Laura Dolcini, Massimiliano Maraglino Misciagna, Yanto Ridwan, Eric Farrell, Gerjo J.V.M. van Osch, Joachim Nickel
Publikováno v:
Bioactive Materials, Vol 29, Iss , Pp 241-250 (2023)
Bone Morphogenetic proteins (BMPs) like BMP2 and BMP7 have shown great potential in the treatment of severe bone defects. In recent in vitro studies, BMP9 revealed the highest osteogenic potential compared to other BMPs, possibly due to its unique si
Externí odkaz:
https://doaj.org/article/45dfb93b0ed2401c8fd6e92803bdb4e3
Autor:
Manuel Weißenberger, Mike Wagenbrenner, Joachim Nickel, Rasmus Ahlbrecht, Torsten Blunk, Andre F. Steinert, Fabian Gilbert
Publikováno v:
Journal of Experimental Orthopaedics, Vol 10, Iss 1, Pp n/a-n/a (2023)
Abstract Purpose Hypertrophic cartilage is an important characteristic of osteoarthritis and can often be found in patients suffering from osteoarthritis. Although the exact pathomechanism remains poorly understood, hypertrophic de‐differentiation
Externí odkaz:
https://doaj.org/article/4d5cf41e237a4938861d1e9315d552a4
Autor:
Jietao Xu, Shorouk Fahmy-Garcia, Marinus A. Wesdorp, Nicole Kops, Lucia Forte, Claudio De Luca, Massimiliano Maraglino Misciagna, Laura Dolcini, Giuseppe Filardo, Margot Labberté, Karin Vancíková, Joeri Kok, Bert van Rietbergen, Joachim Nickel, Eric Farrell, Pieter A. J. Brama, Gerjo J. V. M. van Osch
Publikováno v:
Journal of Functional Biomaterials, Vol 14, Iss 2, p 111 (2023)
Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair
Externí odkaz:
https://doaj.org/article/f851bc6d81cd4f228cab2b3a0e38372f
Autor:
Axel Seher, Charlotte Lagler, Thorsten Stühmer, Urs Dietmar Achim Müller-Richter, Alexander Christian Kübler, Walter Sebald, Thomas Dieter Müller, Joachim Nickel
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0174884 (2017)
Multiple myeloma (MM) represents a haematological cancer characterized by the pathological hyper proliferation of antibody-producing B-lymphocytes. Patients typically suffer from kidney malfunction and skeletal disorders. In the context of MM, the tr
Externí odkaz:
https://doaj.org/article/3990fafe94fc45b0bc0c29833b01d56b
Autor:
Charlotte Lagler, Mohamed El-Mesery, Alexander Christian Kübler, Urs Dietmar Achim Müller-Richter, Thorsten Stühmer, Joachim Nickel, Thomas Dieter Müller, Harald Wajant, Axel Seher
Publikováno v:
PLoS ONE, Vol 12, Iss 10, p e0185720 (2017)
Multiple myeloma (MM), a malignancy of the bone marrow, is characterized by a pathological increase in antibody-producing plasma cells and an increase in immunoglobulins (plasmacytosis). In recent years, bone morphogenetic proteins (BMPs) have been r
Externí odkaz:
https://doaj.org/article/b465a25915f44227a96502f6fecae221
Autor:
Kai Stuckensen, José M. Lamo-Espinosa, Emma Muiños-López, Purificación Ripalda-Cemboráin, Tania López-Martínez, Elena Iglesias, Gloria Abizanda, Ion Andreu, María Flandes-Iparraguirre, Juan Pons-Villanueva, Reyes Elizalde, Joachim Nickel, Andrea Ewald, Uwe Gbureck, Felipe Prósper, Jürgen Groll, Froilán Granero-Moltó
Publikováno v:
Materials, Vol 12, Iss 19, p 3105 (2019)
In the treatment of bone non-unions, an alternative to bone autografts is the use of bone morphogenetic proteins (BMPs), e.g., BMP−2, BMP−7, with powerful osteoinductive and osteogenic properties. In clinical settings, these osteogenic factors ar
Externí odkaz:
https://doaj.org/article/1151fffffc4d4674ac9f431929bddb40
Publikováno v:
Polymers, Vol 11, Iss 7, p 1090 (2019)
Background: Culturing of cells is typically performed on standard tissue culture plates generating growth conditions, which in general do not reflect the native three-dimensional cellular environment. Recent investigations provide insights in paramet
Externí odkaz:
https://doaj.org/article/5b690612f49549bca5539fa3fe458e2b
Autor:
Elisa Degenkolbe, Jana König, Julia Zimmer, Maria Walther, Carsten Reißner, Joachim Nickel, Frank Plöger, Jelena Raspopovic, James Sharpe, Katarina Dathe, Jacqueline T Hecht, Stefan Mundlos, Sandra C Doelken, Petra Seemann
Publikováno v:
PLoS Genetics, Vol 9, Iss 10, p e1003846 (2013)
Growth and Differentiation Factor 5 (GDF5) is a secreted growth factor that belongs to the Bone Morphogenetic Protein (BMP) family and plays a pivotal role during limb development. GDF5 is a susceptibility gene for osteoarthritis (OA) and mutations i
Externí odkaz:
https://doaj.org/article/5d589d0d35e242a3b4722b7e2d69f6a8
Autor:
Uschi Diestel, Marcus Resch, Kathrin Meinhardt, Sigrid Weiler, Tina V Hellmann, Thomas D Mueller, Joachim Nickel, Jutta Eichler, Yves A Muller
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67214 (2013)
The zona pellucida (ZP) domain is present in extracellular proteins such as the zona pellucida proteins and tectorins and participates in the formation of polymeric protein networks. However, the ZP domain also occurs in the cytokine signaling co-rec
Externí odkaz:
https://doaj.org/article/beba21ca4da24ded92fb277fea7ea3aa
Autor:
Petra Seemann, Anja Brehm, Jana König, Carsten Reissner, Sigmar Stricker, Pia Kuss, Julia Haupt, Stephanie Renninger, Joachim Nickel, Walter Sebald, Jay C Groppe, Frank Plöger, Jens Pohl, Mareen Schmidt-von Kegler, Maria Walther, Ingmar Gassner, Cristina Rusu, Andreas R Janecke, Katarina Dathe, Stefan Mundlos
Publikováno v:
PLoS Genetics, Vol 5, Iss 11, p e1000747 (2009)
Signaling output of bone morphogenetic proteins (BMPs) is determined by two sets of opposing interactions, one with heterotetrameric complexes of cell surface receptors, the other with secreted antagonists that act as ligand traps. We identified two
Externí odkaz:
https://doaj.org/article/8d0c86fc903b433fb9ac4193b9a43512