Zobrazeno 1 - 10
of 368
pro vyhledávání: '"Joachim Neumann"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1139 (2024)
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist. GLP-1R agonists are used to treat type 2 diabetes and obesity. It is currently unknown whether semaglutide can directly increase force of contraction (FOC) in the human heart. We tes
Externí odkaz:
https://doaj.org/article/6a78d4276bc04006af37dc53873a16f3
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 16, p 8887 (2024)
The present study examined three hallucinogenic amphetamine derivatives, namely, 2,5-dimethoxy-4-iodoamphetamine (DOI) as well as 2,5-dimethoxy-4-methylamphetamine (DOM) and 4-methylmethcathinone (mephedrone). The objective of this study was to test
Externí odkaz:
https://doaj.org/article/0ec172ccd8bd4bcfa51a189e637299e1
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals
Externí odkaz:
https://doaj.org/article/d08f83af76b94f0599aada5f6b5435bd
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 16, p 12829 (2023)
Glucagon exerts effects on the mammalian heart. These effects include alterations in the force of contraction, beating rate, and changes in the cardiac conduction system axis. The cardiac effects of glucagon vary according to species, region, age, an
Externí odkaz:
https://doaj.org/article/3a50fa417a9049e486f16d6c54075397
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 734 (2023)
Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventr
Externí odkaz:
https://doaj.org/article/10460d39d24b4276bc665fbc1cea86c4
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4765 (2023)
Serotonin acts solely via 5-HT4-receptors to control human cardiac contractile function. The effects of serotonin via 5-HT4-receptors lead to positive inotropic and chronotropic effects, as well as arrhythmias, in the human heart. In addition, 5-HT4-
Externí odkaz:
https://doaj.org/article/387f63b7f08b45afad2d7b4191a5995c
Autor:
Hannes Jacob, Pauline Braekow, Rebecca Schwarz, Christian Höhm, Uwe Kirchhefer, Britt Hofmann, Joachim Neumann, Ulrich Gergs
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 4749 (2023)
Ergotamine (2′-methyl-5′α-benzyl-12′-hydroxy-3′,6′,18-trioxoergotaman) is a tryptamine-related alkaloid from the fungus Claviceps purpurea. Ergotamine is used to treat migraine. Ergotamine can bind to and activate several types of 5-HT1-se
Externí odkaz:
https://doaj.org/article/d3badcf968804fab9be2417d285b0a45
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 5, p 5042 (2023)
Dopamine has effects on the mammalian heart. These effects can include an increase in the force of contraction, and an elevation of the beating rate and the constriction of coronary arteries. Depending on the species studied, positive inotropic effec
Externí odkaz:
https://doaj.org/article/f6f7571cc31f4676a7e711b66933f54f
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electroph
Externí odkaz:
https://doaj.org/article/6df007a70e744e6292446b50f1830f2f
Autor:
Joachim Neumann, Juliane M. Grobe, Jacqueline Weisgut, Hubert G. Schwelberger, Wieslawa Agnieszka Fogel, Margaréta Marušáková, Hartmut Wache, Heike Bähre, Igor B. Buchwalow, Stefan Dhein, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in hum
Externí odkaz:
https://doaj.org/article/b9e038c7f7ca4a09a4890fa49e6fb7b3