Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Joachim Mierau"'
Publikováno v:
Brain Research. 883:216-223
Hydroxyl free radical production seems to play an important role in the pathogenesis of Parkinson's disease. In the present study, we investigated the dopamine agonists pramipexole and pergolide as well as the nitrone compound S-PBN (N-tert-butyl-alp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27457a61dd0ebabae10b2f2c9ce7fde8
https://doi.org/10.1016/s0006-8993(00)02929-2
https://doi.org/10.1016/s0006-8993(00)02929-2
Autor:
Joachim Mierau, Wolf‐Dieter Bechtel, Klaus Mendla, Wolfgang Tröger, Helmut Ensinger, Franz Birke, Georg Speck
Publikováno v:
Drug Development Research. 40:144-157
The functional selectivity of WAL 2014 FU with regard to stimulation of the neuronal muscarinic M1 receptor subtype in vitro and in vivo is shown in different receptor preparations, isolated organ models, whole animal testing, and finally humans. Fro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8303f9fe48efcb80c413e5bc858702cb
https://doi.org/10.1002/(sici)1098-2299(199702)40:2<144::aid-ddr5>3.0.co
https://doi.org/10.1002/(sici)1098-2299(199702)40:2<144::aid-ddr5>3.0.co
Autor:
Mary E. Lajiness, Christopher L. Chio, Helmut Ensinger, Joachim Mierau, Rita M. Huff, Franz J. Schneider
Publikováno v:
European Journal of Pharmacology: Molecular Pharmacology. 290:29-36
Pramipexole (SND 919; 2-amino-4,5,6,7-tetrahydro-6-propylamino-benzthiazole-dihydrochlor ide) is a potent dopamine autoreceptor agonist. We have carried out an analysis of the binding affinities of dopamine D2L, D2S, D3, and D4 receptors for pramipex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c48634ab98147d51650981fa7a1a6232
https://doi.org/10.1016/0922-4106(95)90013-6
https://doi.org/10.1016/0922-4106(95)90013-6
Publikováno v:
Archiv der Pharmazie. 328:609-614
The novel aminobenzindolone 8 was prepared and evaluated as a potential antipsychotic agent. The target compound was synthesized in eight steps starting from the tetrahydrobenzindolone 9. The key step of the synthesis was an electrophilic amination o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba80f40cb39165f8a4f04505ede77cd
https://doi.org/10.1002/ardp.19953280708
https://doi.org/10.1002/ardp.19953280708
Autor:
Joachim Mierau
Publikováno v:
Clinical Neuropharmacology. 18:S195-S206
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5d9c5a708b8ad77556107505c6d65f04
https://doi.org/10.1097/00002826-199501001-00021
https://doi.org/10.1097/00002826-199501001-00021
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:1477-1483
Based on molecular modeling studies on the electronic properties of dopamine and dopamine agorusts the pyraz.o10(1,5-alpyridine structure has been evaluated as a catechol surrogate. The azaergoline analogue 6, including this moiety has been synthesiz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b8b9edff11590692eb7264664ae73a0
https://doi.org/10.1016/s0960-894x(00)80003-7
https://doi.org/10.1016/s0960-894x(00)80003-7
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c21ecece60ce5e78b660cec84786f09a
https://doi.org/10.1002/chin.199551185
https://doi.org/10.1002/chin.199551185
Publikováno v:
ChemInform. 26
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b24e22249a44140fa3400ce4d4b04bf
https://doi.org/10.1002/chin.199551129
https://doi.org/10.1002/chin.199551129
Autor:
Gunter Schingnitz, Joachim Mierau
Publikováno v:
European Journal of Pharmacology. 215:161-170
Pramipexole (SND 919; 2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole- dihydrochloride) was tested for its agonistic activity at pre- and postsynaptic dopamine (DA) receptors. L-Dihydroxyphenylalanine (L-dopa) accumulation in the rat striatum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8492283ce62bee18b371d25897e68c87
https://doi.org/10.1016/0014-2999(92)90024-x
https://doi.org/10.1016/0014-2999(92)90024-x
Publikováno v:
Archiv der Pharmazie. 325:649-655
As an extension of previous investigations on synthesis and dopamine autoreceptor activity of bicyclic ergoline analogues the tricyclic azaergoline analogues 9a and 9b were synthesized. Furthermore, the geometry of the aromatic β-ethylamine moiety o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c17bf90bcec2200daa3e400f4cc16aa5
https://doi.org/10.1002/ardp.19923251007
https://doi.org/10.1002/ardp.19923251007