Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Joachim Malotka"'
Autor:
Eduardo Beltrán, Manuela Paunovic, David Gebert, Emine Cesur, Markus Jeitler, Romana Höftberger, Joachim Malotka, Simone Mader, Naoto Kawakami, Edgar Meinl, Monika Bradl, Klaus Dornmair, Hans Lassmann
Publikováno v:
Acta Neuropathologica
Aim of our study was to identify the target auto-antigen in the central nervous system recognized by the immune system of a unique patient, who died more than 60 years ago from a disease with pathological changes closely resembling multiple sclerosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375806087baba1e6d9b4aff7164ca92e
https://doi.org/10.1007/s00401-020-02239-2
https://doi.org/10.1007/s00401-020-02239-2
Autor:
Katherina Siewert, Birgit Obermeier, Reinhard Hohlfeld, Joachim Malotka, Josef Kellermann, Jessica Bruder, Klaus Dornmair, Takuya Ueda, Peter Scheinert
Publikováno v:
Journal of Biological Chemistry. 287:20986-20995
In polymyositis and inclusion body myositis, muscle fibers are surrounded and invaded by CD8-positive cytotoxic T cells expressing the αβ-T cell receptor (αβ-TCR) for antigen. In a rare variant of myositis, muscle fibers are similarly attacked by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d6570f11d30457da9a93f3851e775fc
https://doi.org/10.1074/jbc.m112.356709
https://doi.org/10.1074/jbc.m112.356709
Autor:
Hartmut Wekerle, Katherina Siewert, Joachim Malotka, Klaus Dornmair, Reinhard Hohlfeld, Naoto Kawakami
Publikováno v:
Nature Medicine. 18:824-828
Cytotoxic CD8(+) T cells recognize the antigenic peptides presented by class I major histocompatibility complex (MHC) molecules. These T cells have key roles in infectious diseases, autoimmunity and tumor immunology, but there is currently no unbiase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ae3f7b20c9485645359ed39e4f3b6c
https://doi.org/10.1038/nm.2720
https://doi.org/10.1038/nm.2720
Autor:
Reinhard Mentele, Joachim Malotka, Hartmut Wekerle, Klaus Dornmair, Tania Kümpfel, R. Hohlfeld, Josef Kellermann, Friedrich Lottspeich, Birgit Obermeier
Publikováno v:
Nature Medicine. 14:688-693
We describe a method for correlating the immunoglobulin (Ig) proteomes with the B cell transcriptomes in human fluid and tissue samples, using multiple sclerosis as a paradigm. Oligoclonal Ig bands and elevated numbers of clonally expanded B cells in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebcefa7b9ddb69ad8bdb2c5cad29240
https://doi.org/10.1038/nm1714
https://doi.org/10.1038/nm1714
Autor:
Hartmut Wekerle, Edgar Meinl, Reinhard Hohlfeld, Joachim Malotka, Ingrid Eiglmeier, Klaus Dornmair, Jana Ivanidze, Andreas Junker, Hans Lassmann
Publikováno v:
Brain. 130:2789-2799
Multiple sclerosis (MS) is an inflammatory demyelinating disease where T cells attack the brain and the spinal cord. It is known that often particular T-cell clones are expanded in the target tissue, but it is still unknown, whether identical T-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c94a68a6a3ed34095e00ceeebb7efa4
https://doi.org/10.1093/brain/awm214
https://doi.org/10.1093/brain/awm214
Autor:
Klaus Dornmair, Andrew G. Engel, Joachim Malotka, Christian Schneider, Hartmut Wekerle, Reinhard Hohlfeld, Xiao Nong, Sabine Seitz
Publikováno v:
Proceedings of the National Academy of Sciences. 103:12057-12062
We describe a strategy to “revive” putatively pathogenic T cells from frozen specimens of human inflammatory target organs. To distinguish pathogenic from irrelevant bystander T cells, we focused on cells that were ( i ) clonally expanded and ( i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab8b25f57f79eb8510f99eb3ce34656
https://doi.org/10.1073/pnas.0604247103
https://doi.org/10.1073/pnas.0604247103
Autor:
Georg Dechant, Reinhard Hohlfeld, Klaus Dornmair, Heinz Wiendl, Joachim Malotka, Christian Schneider
Publikováno v:
Journal of Neuroimmunology. 152:168-175
Previously we partially characterized an autoreactive human Vgamma1.3Vdelta2-T-cell receptor (TCR) that had originally been identified in muscle of a patient with an unusual form of polymyositis. This TCR recognizes a muscle-associated auto-antigen i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e2d7e54cd1e317eb20e6a49b5e7f770
https://doi.org/10.1016/j.jneuroim.2004.03.016
https://doi.org/10.1016/j.jneuroim.2004.03.016
Autor:
Klaus Dornmair, Hans Ulrich Weltzien, Brigitte Holzwarth, Heinz Wiendl, Hartmut Wekerle, Joachim Malotka, Reinhard Hohlfeld
Publikováno v:
The Journal of Immunology. 169:515-521
To investigate the role of gammadelta T cells in human autoimmune disease we expressed and characterized a gammadelta TCR from an autoimmune tissue lesion. The TCR was first identified in a rare form of polymyositis characterized by a monoclonal infi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ae6c05dea2132753f642b7fff37f178
https://doi.org/10.4049/jimmunol.169.1.515
https://doi.org/10.4049/jimmunol.169.1.515
Autor:
Raymond Voltz, Klaus Dornmair, Simone Spuler, Joachim Malotka, Martin Kerschensteiner, Frank Padberg, Socrates J. Tzartos, Christoph Kamm
Publikováno v:
Journal of Neuroimmunology. 80:131-136
Using recombinantly expressed proteins for selection of antigen-specific T cell lines carries a high risk of selecting T cells specific for contaminating proteins. This risk is especially high for very hydrophobic proteins which are notoriously diffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d22d0042a2682afd45e653a0659d6c
https://doi.org/10.1016/s0165-5728(97)00147-1
https://doi.org/10.1016/s0165-5728(97)00147-1
Publikováno v:
European Journal of Biochemistry. 248:684-691
We investigated the mechanism of refolding and reassembly of recombinant alpha and beta chains of the class II major histocompatibility molecules (MHC-II) HLA-DRB5*0101. Both chains were expressed in the cytosol of Escherichia coli, purified in urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d0897ca5d29091ae2e6124ec81fc730
https://doi.org/10.1111/j.1432-1033.1997.t01-2-00684.x
https://doi.org/10.1111/j.1432-1033.1997.t01-2-00684.x