Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Joachim Lingner"'
Autor:
Giulia Bottoni, Atul Katarkar, Beatrice Tassone, Soumitra Ghosh, Andrea Clocchiatti, Sandro Goruppi, Pino Bordignon, Paris Jafari, Fabio Tordini, Thomas Lunardi, Wolfram Hoetzenecker, Victor Neel, Joachim Lingner, G. Paolo Dotto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Conversion of dermal fibroblasts into Cancer Associated Fibroblasts (CAFs) can play an important role in keratinocyte tumour development. Here the authors reveal that CSL plays a role in maintenance of telomeres and genomic integrity in both dermal f
Externí odkaz:
https://doaj.org/article/82b5056962d14041aae036cba6d017e3
Autor:
Wareed Ahmed, Joachim Lingner
Publikováno v:
Cell Reports, Vol 33, Iss 5, Pp 108347- (2020)
Summary: Telomeres are prone to damage inflicted by reactive oxygen species (ROS). Oxidized telomeric DNA and nucleotide substrates inhibit telomerase, causing telomere shortening. In addition, ROS can induce telomeric single-strand DNA breaks (SSBs)
Externí odkaz:
https://doaj.org/article/2e47e9cd713b4e4db0e06a7c3e34d1e1
Publikováno v:
Cell Reports, Vol 17, Iss 12, Pp 3107-3114 (2016)
Oxidative damage of telomeres can promote cancer, cardiac failure, and muscular dystrophy. Specific mechanisms protecting telomeres from oxidative damage have not been described. We analyzed telomeric chromatin composition during the cell cycle and s
Externí odkaz:
https://doaj.org/article/07e78fbb34ed483da8e2ec822ce90354
Publikováno v:
Cell Reports, Vol 6, Iss 4, Pp 765-776 (2014)
Telomeres protect chromosome ends from being recognized as sites of DNA damage. Upon telomere shortening or telomere uncapping induced by loss of telomeric repeat-binding factor 2 (TRF2), telomeres elicit a DNA-damage response leading to cellular sen
Externí odkaz:
https://doaj.org/article/80933708d3e441eba6d81bc2b172cfc9
Autor:
Verena Pfeiffer, Joachim Lingner
Publikováno v:
PLoS Genetics, Vol 8, Iss 6, p e1002747 (2012)
The long noncoding telomeric repeat containing RNA (TERRA) is expressed at chromosome ends. TERRA upregulation upon experimental manipulation or in ICF (immunodeficiency, centromeric instability, facial anomalies) patients correlates with short telom
Externí odkaz:
https://doaj.org/article/5c36d57357374a22a58f801ab0231e31
Autor:
Alexandra Vancevska, Joachim Lingner, Chih-Yi Gabriela Lin, Anna Christina Naeger, Thomas Lunardi, Gérald Lossaint
Publikováno v:
Nucleic Acids Research
Telomere shortening can cause detrimental diseases and contribute to aging. It occurs due to the end replication problem in cells lacking telomerase. Furthermore, recent studies revealed that telomere shortening can be attributed to difficulties of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90c389a0b2fa0d68eeaf64c741939bb
https://doi.org/10.1093/nar/gkab1015
https://doi.org/10.1093/nar/gkab1015
Autor:
Galina, Glousker, Joachim, Lingner
Publikováno v:
Genesdevelopment. 36(17-18)
Although telomeres are essential for chromosome stability, they represent fragile structures in our genome. Telomere shortening occurs during aging in cells lacking telomerase due to the end replication problem. In addition, recent work uncovered tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4a780d85f32cf69ac0956bf5cbd46a7f
https://pubmed.ncbi.nlm.nih.gov/36347559
https://pubmed.ncbi.nlm.nih.gov/36347559
Publikováno v:
Cell Cycle
article-version (VoR) Version of Record
article-version (VoR) Version of Record
Telomeres protect chromosome ends from nucleolytic degradation, uncontrolled recombination by DNA repair enzymes and checkpoint signaling, and they provide mechanisms for their maintenance by semiconservative DNA replication, telomerase and homologou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b77c5535c449a1717181b13c935d2c
https://doi.org/10.1080/15384101.2021.1962638
https://doi.org/10.1080/15384101.2021.1962638
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2528
R-loops are three-stranded nucleic acid structures composed of a DNA-RNA hybrid and a displaced DNA strand. The long noncoding RNA TERRA forms R-loops at telomeres influencing the telomeric chromatin composition and impacting on telomere maintenance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::811c5f855062a00712a534465d62130e
https://pubmed.ncbi.nlm.nih.gov/35704191
https://pubmed.ncbi.nlm.nih.gov/35704191
Publikováno v:
R-Loops ISBN: 9781071624760
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a35f4d992b653e9fadd2b0a38d10e778
https://doi.org/10.1007/978-1-0716-2477-7_11
https://doi.org/10.1007/978-1-0716-2477-7_11
