Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Joachim Lauterwasser"'
Autor:
Franziska Fimm-Todt, Ezgi Dikici, Katharina Schaich, Oliver Siedentopf, Joachim Lauterwasser, Daniel Feger, Jan Erik Ehlert
Publikováno v:
Cancer Research. 83:549-549
The proto-oncogene KRas is a well-described small GTPase that functions as a molecular switch for major physiological signaling pathways involved in cell proliferation, differentiation and survival. It has been shown that activating mutations in KRas
Autor:
Frank Edlich, Franziska Fimm-Todt, Martin van der Laan, Joachim Lauterwasser, Hugo Falquez-Medina, Katelyn O'Neill, Günther Jahreis, Xu Luo, Aline Oelgeklaus, Kathrin Funk, Ralf M. Zerbes, Annabell Schreiner, Ramona Klesse
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Receptor–ligand interactions on the cell surface or intrinsic stress signals can commit mammalian cells to apoptosis. In this study, we discover how hexokinases confer resistance to receptor-mediated apoptosis through specific inhibiti
Autor:
Laura M. Jordt, Frank Totzke, Joachim Lauterwasser, Jan E. Ehlert, Koen Hekking, Bas Aerts, Cynthia Obodozie, Holger Weber, Gerhard Müller, Michael H. Kubbutat
Publikováno v:
Cancer Research. 82:2318-2318
CDK8 has been identified as being frequently upregulated in various types of human cancer such as colorectal cancer, certain sub-types of breast cancer and acute myeloid leukemia. In different tumor cell lines RNA interference mediated knockdown of C
Autor:
Franziska Fimm-Todt, Joachim Lauterwasser, Eva-Maria Egenter, Christian Weber, Daniel Feger, Katharina Schaich, Sarah Ulrich, Oliver Siedentopf, Frank Totzke, Michael Kubbutat, Jan Erik Ehlert
Publikováno v:
Cancer Research. 82:4072-4072
Leucin-rich repeat kinase 2 (LRRK2) plays an important role in the onset of sporadic as well as familial Parkinson’s disease. Pathogenic gain-of-function mutations of LRRK2 are associated with aberrant LRRK2 hyperactivity which results in neurotoxi
Autor:
Eman Al-Shehri, Hugo Falquez, Frank Edlich, Rajnikant Patel, Joachim Lauterwasser, Omeed O. Darweesh
Publikováno v:
Journal of cell science. 134(8)
In eukaryotes, entry into and exit from mitosis is regulated, respectively, by the transient activation and inactivation of Cdk1. Taxol, an anti-microtubule anti-cancer drug, prevents microtubule–kinetochore attachments to induce spindle assembly c
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1877
BCL-2 proteins control stress-dependent commitment to the programmed cell death apoptosis. In nonapoptotic cells the proapoptotic BCL-2 proteins BAX and BAK but also prosurvival family members, like BCL-x
Publikováno v:
Methods in Molecular Biology ISBN: 9781493988600
BCL-2 proteins control stress-dependent commitment to the programmed cell death apoptosis. In nonapoptotic cells the proapoptotic BCL-2 proteins BAX and BAK but also prosurvival family members, like BCL-xL or MCL-1, translocate to the outer mitochond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf8c4754a18906163671cffa013f580e
https://doi.org/10.1007/978-1-4939-8861-7_10
https://doi.org/10.1007/978-1-4939-8861-7_10
Autor:
Frank Reichenbach, Frank Edlich, Franziska Todt, Joachim Lauterwasser, Gabriel Ichim, Frederic Emschermann, Harald F. Langer, Stephen W.G. Tait, Andrea Kaiser, Stephan Frank, Zeynep Cakir
Publikováno v:
The EMBO Journal. 34:67-80
The Bcl-2 proteins Bax and Bak can permeabilize the outer mitochondrial membrane and commit cells to apoptosis. Pro-survival Bcl-2 proteins control Bax by constant retrotranslocation into the cytosol of healthy cells. The stabilization of cytosolic B
Autor:
Zeynep Cakir, Kathrin Funk, Franziska Todt, Martin van der Laan, Frank Edlich, Ralf M. Zerbes, Aline Oelgeklaus, Atsushi Tanaka, Joachim Lauterwasser
Publikováno v:
Journal of cell science. 130(17)
The pro-apoptotic BCL-2 protein BAX commits human cells to apoptosis by permeabilizing the outer mitochondrial membrane. BAX activation has been suggested to require the separation of helix α5 from α6 and thus the ‘latch’ from the ‘core’ do
Autor:
Martin van der Laan, Frank Edlich, Thanh Ngoc Nguyen, Joachim Lauterwasser, William J. Craigen, Ralf M. Zerbes, Franziska Todt, Michael Lazarou
Publikováno v:
Scientific Reports
The pro-apoptotic Bcl-2 protein Bax can permeabilize the outer mitochondrial membrane and therefore commit human cells to apoptosis. Bax is regulated by constant translocation to the mitochondria and retrotranslocation back into the cytosol. Bax retr