Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Joachim Kremerskothen"'
Autor:
Denise Beckmann, Anja Römer-Hillmann, Annika Krause, Uwe Hansen, Corinna Wehmeyer, Johanna Intemann, David J. J. de Gorter, Berno Dankbar, Jan Hillen, Marianne Heitzmann, Isabell Begemann, Milos Galic, Toni Weinhage, Dirk Foell, Rizi Ai, Joachim Kremerskothen, Hans P. Kiener, Sylvia Müller, Thomas Kamradt, Christopher Schröder, Elsa Leitão, Bernhard Horsthemke, Philip Rosenstiel, Karl Nordström, Gilles Gasparoni, Nina Gasparoni, Jörn Walter, Na Li, Xinyi Yang, Ho-Ryun Chung, Hermann Pavenstädt, Nico Lindemann, Hans J. Schnittler, Wei Wang, Gary S. Firestein, Thomas Pap, Adelheid Korb-Pap
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Fibroblast-like synoviocytes are important mediators of joint pathology in rheumatoid arthritis (RA). Here the authors show that Lasp1 is epigenetically regulated and highly expressed by these cells in RA and its deletion can limit joint pathology in
Externí odkaz:
https://doaj.org/article/6eeabbe32b3249c9843c922ebc496340
Autor:
Anke Hermann, Guangming Wu, Pavel I. Nedvetsky, Viktoria C. Brücher, Charlotte Egbring, Jakob Bonse, Verena Höffken, Dirk Oliver Wennmann, Matthias Marks, Michael P. Krahn, Hans Schöler, Peter Heiduschka, Hermann Pavenstädt, Joachim Kremerskothen
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Abstract The WW-and-C2-domain-containing (WWC) protein family is involved in the regulation of cell differentiation, cell proliferation, and organ growth control. As upstream components of the Hippo signaling pathway, WWC proteins activate the Large
Externí odkaz:
https://doaj.org/article/5558975e38b6443abbd9e8c7c04cf744
Autor:
Viktoria Constanze Brücher, Charlotte Egbring, Tanja Plagemann, Pavel I. Nedvetsky, Verena Höffken, Hermann Pavenstädt, Nicole Eter, Joachim Kremerskothen, Peter Heiduschka
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5321 (2021)
The WWC protein family is an upstream regulator of the Hippo signalling pathway that is involved in many cellular processes. We examined the effect of an endothelium-specific WWC1 and/or WWC2 knock-out on ocular angiogenesis. Knock-outs were induced
Externí odkaz:
https://doaj.org/article/ec64fb2f1c384e769795368e9a5d4ebe
Autor:
Miriam Stölting, Christiane Wiesner, Vanessa van Vliet, Elke Butt, Hermann Pavenstädt, Stefan Linder, Joachim Kremerskothen
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35340 (2012)
Eukaryotic cells form a variety of adhesive structures to connect with their environment and to regulate cell motility. In contrast to classical focal adhesions, podosomes, highly dynamic structures of different cell types, are actively engaged in ma
Externí odkaz:
https://doaj.org/article/3dd46816025347d79454ca83923c27b3
Autor:
Carine Rosse, Etienne Formstecher, Katrina Boeckeler, Yingming Zhao, Joachim Kremerskothen, Michael D White, Jacques H Camonis, Peter J Parker
Publikováno v:
PLoS Biology, Vol 7, Iss 11, p e1000235 (2009)
Atypical protein kinase C (aPKC) isoforms have been implicated in cell polarisation and migration through association with Cdc42 and Par6. In distinct migratory models, the Exocyst complex has been shown to be involved in secretory events and migrati
Externí odkaz:
https://doaj.org/article/95fc10a001594aa89e24f2036822ba77
Autor:
Weicheng Luo, Yi Li, Yi Zeng, Yining Li, Minzhang Cheng, Cheng Zhang, Fei Li, Yiqing Wu, Chunhong Huang, Xiaolong Yang, Joachim Kremerskothen, Jianmin Zhang, Chunbo Zhang, Shuo Tu, Zhihua Li, Zhijun Luo, Zhenghong Lin, Xiaohua Yan
Publikováno v:
Journal of Molecular Cell Biology.
Tea domain transcriptional factor 4 (TEAD4) plays a pivotal role in tissue development and homeostasis by interacting with YAP in response to Hippo signaling inactivation. TEAD4 and YAP can also cooperate with TGF-β-activated Smad proteins to regula
Autor:
Verena Höffken, Sara Di Persio, Sandra Laurentino, Margot J. Wyrwoll, Nicole Terwort, Anke Hermann, Albrecht Röpke, Manon S. Oud, Joachim Wistuba, Sabine Kliesch, Hermann J. Pavenstädt, Frank Tüttelmann, Nina Neuhaus, Joachim Kremerskothen
Publikováno v:
The Faseb Journal, 37, 5
The Faseb Journal, 37
The Faseb Journal, 37
Contains fulltext : 292362.pdf (Publisher’s version ) (Open Access) The family of WWC proteins is known to regulate cell proliferation and organ growth control via the Hippo signaling pathway. As WWC proteins share a similar domain structure and a
Autor:
Pavel I. Nedvetsky, Matthias Marks, Anke Hermann, Hermann Pavenstädt, Charlotte Egbring, Dirk Oliver Wennmann, Peter Heiduschka, Joachim Kremerskothen, Michael P. Krahn, Jakob Bonse, Guangming Wu, Viktoria C. Brücher, Hans R. Schöler, Verena Höffken
Publikováno v:
Cell Death and Disease, Vol 12, Iss 1, Pp 1-14 (2021)
Cell Death & Disease
Cell Death & Disease
The WW-and-C2-domain-containing (WWC) protein family is involved in the regulation of cell differentiation, cell proliferation, and organ growth control. As upstream components of the Hippo signaling pathway, WWC proteins activate the Large tumor sup
Autor:
Jens, Stepan, Daniel E, Heinz, Frederik, Dethloff, Thomas, Bajaj, Andreas, Zellner, Kathrin, Hafner, Svenja, Wiechmann, Sarah, Mackert, Yara, Mecdad, Michael, Rabenstein, Tim, Ebert, Silvia, Martinelli, Alexander S, Häusl, Maximilian L, Pöhlmann, Anke, Hermann, Xiao, Ma, Hermann, Pavenstädt, Mathias V, Schmidt, Alexandra, Philipsen, Chris W, Turck, Jan M, Deussing, Bernhard, Kuster, Michael C, Wehr, Valentin, Stein, Joachim, Kremerskothen, Carsten T, Wotjak, Nils C, Gassen
Publikováno v:
Cell reports. 41(10)
Learning and memory rely on changes in postsynaptic glutamergic α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type receptor (AMPAR) number, spatial organization, and function. The Hippo pathway component WW and C2 domain-containing pro
Autor:
Rizi Ai, Uwe Hansen, Johanna Intemann, Elsa Leitão, Toni Weinhage, Isabell Begemann, Joachim Kremerskothen, Anja Römer-Hillmann, Ho-Ryun Chung, Marianne Heitzmann, Thomas Pap, Hermann Pavenstädt, Hans P. Kiener, Na Li, Annika Krause, Wei Wang, Gilles Gasparoni, Berno Dankbar, Sylvia Müller, Corinna Wehmeyer, Denise Beckmann, Dirk Foell, Philip Rosenstiel, Bernhard Horsthemke, Thomas Kamradt, Adelheid Korb-Pap, Karl Nordström, Hans Schnittler, David J. J. de Gorter, Nico Lindemann, Jörn Walter, Gary S. Firestein, Xinyi Yang, Nina Gasparoni, Christopher Schröder, Jan Hillen, Milos Galic
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
The LIM and SH3 domain protein 1 (Lasp1) was originally cloned from metastatic breast cancer and characterised as an adaptor molecule associated with tumourigenesis and cancer cell invasion. However, the regulation of Lasp1 and its function in the ag