Zobrazeno 1 - 10
of 200
pro vyhledávání: '"Joachim Klose"'
Autor:
Stefanie Forler, Oliver Klein, Sebastian Köhler, Peter N. Robinson, Henning Witt, Marc Sultan, Murat Eravci, Vera Regitz-Zagrosek, Hans Lehrach, Joachim Klose
Publikováno v:
EuPA Open Proteomics, Vol 7, Iss C, Pp 27-42 (2015)
We investigated to which extent polymorphisms of an individual affect the proteomic network. Consomic mouse strains (CS) were used to study the trans-effect of the cis-variant (polymorphic) proteins of the strain PWD/Ph on the proteins of the host st
Externí odkaz:
https://doaj.org/article/ac1e301086eb464597015b321f85f297
Autor:
Daniela Hartl, Stephan Klatt, Manfred Roch, Zoltan Konthur, Joachim Klose, Thomas E Willnow, Michael Rohe
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e65920 (2013)
A growing body of evidence suggests a role for soluble alpha-amyloid precursor protein (sAPPalpha) in pathomechanisms of Alzheimer disease (AD). This cleavage product of APP was identified to have neurotrophic properties. However, it remained enigmat
Externí odkaz:
https://doaj.org/article/a6fcd13ffd1140cd9b1cfeebb78d998f
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e72164 (2013)
Stimulation of neurons with brain-derived neurotrophic factor (BDNF) results in robust induction of SORLA, an intracellular sorting receptor of the VPS10P domain receptor gene family. However, the relevance of SORLA for BDNF-induced neuronal response
Externí odkaz:
https://doaj.org/article/9ad47af1ab154892a277ce96203b14e5
Autor:
Marc Trimborn, Mahdi Ghani, Diego J Walther, Monika Dopatka, Véronique Dutrannoy, Andreas Busche, Franziska Meyer, Stefanie Nowak, Jean Nowak, Claus Zabel, Joachim Klose, Veronica Esquitino, Masoud Garshasbi, Andreas W Kuss, Hans-Hilger Ropers, Susanne Mueller, Charlotte Poehlmann, Ioannis Gavvovidis, Detlev Schindler, Karl Sperling, Heidemarie Neitzel
Publikováno v:
PLoS ONE, Vol 5, Iss 2, p e9242 (2010)
Mutations in the human gene MCPH1 cause primary microcephaly associated with a unique cellular phenotype with premature chromosome condensation (PCC) in early G2 phase and delayed decondensation post-mitosis (PCC syndrome). The gene encodes the BRCT-
Externí odkaz:
https://doaj.org/article/770b07381bfb4877a4b16fab25d1cd22
Autor:
Anna Melchers, Lars Stöckl, Janina Radszewski, Marco Anders, Harald Krenzlin, Candy Kalischke, Regina Scholz, Andreas Jordan, Grit Nebrich, Joachim Klose, Karl Sperling, Martin Digweed, Ilja Demuth
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5423 (2009)
BackgroundThe NBN gene codes for the protein nibrin, which is involved in the detection and repair of DNA double strand breaks (DSBs). The NBN gene is essential in mammals.Methodology/principal findingsWe have used a conditional null mutant mouse mod
Externí odkaz:
https://doaj.org/article/cdf537450a1d4aebbc16ca29599ebf77
Autor:
Anna Melchers, Lars Stöckl, Janina Radszewski, Marco Anders, Harald Krenzlin, Candy Kalischke, Regina Scholz, Andreas Jordan, Grit Nebrich, Joachim Klose, Karl Sperling, Martin Digweed, Ilja Demuth
Publikováno v:
PLoS ONE, Vol 4, Iss 5 (2009)
Externí odkaz:
https://doaj.org/article/5df7dccac4014df0b88e369fc0baec07
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2759 (2008)
The amyloid precursor protein (APP) was assumed to be an important neuron-morphoregulatory protein and plays a central role in Alzheimer's disease (AD) pathology. In the study presented here, we analyzed the APP-transgenic mouse model APP23 using 2-d
Externí odkaz:
https://doaj.org/article/290a02b6ab8c43b1a8b1c8dd25d3dca8
Autor:
Lei Mao, Claus Zabel, Marion Herrmann, Tobias Nolden, Florian Mertes, Laetitia Magnol, Caroline Chabert, Daniela Hartl, Yann Herault, Jean Maurice Delabar, Thomas Manke, Heinz Himmelbauer, Joachim Klose
Publikováno v:
PLoS ONE, Vol 2, Iss 11, p e1218 (2007)
Large numbers of protein expression changes are usually observed in mouse models for neurodegenerative diseases, even when only a single gene was mutated in each case. To study the effect of gene dose alterations on the cellular proteome, we carried
Externí odkaz:
https://doaj.org/article/5065c314a4024520991ee0fa329f480d
Autor:
Sami Zaqout, Atef Mannaa, Oliver Klein, Angelika Krajewski, Joachim Klose, Lena Luise‐Becker, Ahmed Elsabagh, Khaled Ferih, Nadine Kraemer, Ethiraj Ravindran, Konstantin Makridis, Angela M. Kaindl
Publikováno v:
Annals of human geneticsREFERENCES.
Background/aim: : Autosomal recessive primary microcephaly (MCPH) is a rare and genetically heterogeneous group of disorders characterized by intellectual disability and microcephaly at birth, classically without further organ involvement. MCPH3 is c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::793c6d012ac8a38b680c86176743e8c0
https://pubmed.ncbi.nlm.nih.gov/36448252
https://pubmed.ncbi.nlm.nih.gov/36448252
Publikováno v:
Intermetallics. 103:12-22
Plenty of papers with regard to the processing of TiAl alloys via investment casting, forging, rolling, extrusion pressing as well as mechanical machining have been published, whereas the manufacturing of gamma-TiAl based alloys and corresponding sem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51f752943b8439160a39756155861c3a
https://doi.org/10.1016/j.intermet.2018.09.006
https://doi.org/10.1016/j.intermet.2018.09.006