Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joachim H. Mortensen"'
Autor:
Marta S. Alexdottir, Martin Pehrsson, Viktor Domislovic, Line E. Godskesen, Aleksander Krag, Jens Kjeldsen, Marko Brinar, Ana Barisic, Anne-Christine Bay-Jensen, Morten A. Karsdal, Zeljko Krznaric, Joachim H. Mortensen
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-12 (2024)
Abstract Neutrophils play a significant role in sustaining chronic inflammation in Inflammatory Bowel Disease. The intestinal basement membrane acts as a barrier for immunological homeostasis, where the α3 and α4 chains of type IV collagen are expr
Externí odkaz:
https://doaj.org/article/36ce61ebf75c4f13b829c1c0aa30a870
Autor:
Majken Lindholm, Line E. Godskesen, Tina Manon-Jensen, Jens Kjeldsen, Aleksander Krag, Morten A. Karsdal, Joachim H. Mortensen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Abstract In inflammatory bowel disease (IBD), the chronic inflammation deeply affects the intestinal extracellular matrix. The aim of this study was to investigate if remodeling of the intestinal basement membrane type VI collagen was associated with
Externí odkaz:
https://doaj.org/article/972d3bdc2a5b456d8909432fa73adc04
Autor:
Marta S. Alexdottir, Arno R. Bourgonje, Morten A. Karsdal, Martin Pehrsson, Roberta Loveikyte, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra, Joachim H. Mortensen
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
BackgroundCrohn’s disease (CD) is characterized by excessive protease activity and extracellular matrix (ECM) remodeling. To date, 30–50% of patients experience non-response to anti-TNF-α treatment. This study aimed to assess whether serological
Externí odkaz:
https://doaj.org/article/fff2a2308066439c9000ede3fd3ae70f
Autor:
Neel I. Nissen, Stephanie Kehlet, Mogens K. Boisen, Maria Liljefors, Christina Jensen, Astrid Z. Johansen, Julia S. Johansen, Janine T. Erler, Morten Karsdal, Joachim H. Mortensen, Anette Høye, Nicholas Willumsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract A desmoplastic colorectal cancer stroma, characterized by excess turnover of the cancer-associated fibroblast derived collagens type III and VI, can lead to reduced drug-uptake and poor treatment response. We investigated the association bet
Externí odkaz:
https://doaj.org/article/6976c8000d604bf1872674bfffb96a35
Autor:
Marta S. Alexdottir, Arno R. Bourgonje, Morten A. Karsdal, Martin Pehrsson, Roberta Loveikyte, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Klaas Nico Faber, Gerard Dijkstra, Joachim H. Mortensen
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 15, p 8137 (2022)
Crohn’s disease (CD) is a relapsing-remitting inflammatory disease of the gastrointestinal (GI) tract characterized by increased extracellular matrix (ECM) remodeling. The introduction of the α4β7-integrin inhibitor vedolizumab (VEDO) has improve
Externí odkaz:
https://doaj.org/article/86aec7cd862f4bb7a5aa85eb0a5b04aa
Autor:
Christina Jensen, Signe H. Nielsen, Joachim H. Mortensen, Jens Kjeldsen, Lone G. Klinge, Aleksander Krag, Henrik Harling, Lars N. Jørgensen, Morten A. Karsdal, Nicholas Willumsen
Publikováno v:
Cancer Medicine, Vol 7, Iss 9, Pp 4619-4626 (2018)
Abstract Altered extracellular matrix (ECM) remodeling is an important part of the pathology of gastrointestinal (GI) disorders. In the intestine, type XVI collagen (col‐16) plays a role in pathogenesis by affecting ECM architecture and induce cell
Externí odkaz:
https://doaj.org/article/20d2f5b5683940e5b4c7faef6b89aa40
Autor:
Arno R. Bourgonje, Marta S. Alexdottir, Antonius T. Otten, Roberta Loveikyte, Anne‐Christine Bay‐Jensen, Martin Pehrsson, Hendrik M. van Dullemen, Marijn C. Visschedijk, Eleonora A. M. Festen, Rinse K. Weersma, Morten A. Karsdal, Klaas Nico Faber, Joachim H. Mortensen, Gerard Dijkstra
Publikováno v:
Alimentary Pharmacology & Therapeutics, 56(4), 675-693. Wiley
Background: Increased collagen remodelling is a key pathophysiological component underlying intestinal stricture and fistula development in Crohn's disease (CD).Aims: To investigate associations between serological biomarkers of collagen turnover and
Autor:
Martin Pehrsson, Tina Manon‐Jensen, Shu Sun, Ida F. Villesen, Helena Castañé, Jorge Joven, Keyur Patel, Zachary Goodman, Mette J. Nielsen, Anne‐Christine Bay‐Jensen, Diana J. Leeming, Joachim H. Mortensen, Morten A. Karsdal
Publikováno v:
Pehrsson, M, Manon-Jensen, T, Sun, S, Villesen, I F, Castañé, H, Joven, J, Patel, K, Goodman, Z, Nielsen, M J, Bay-Jensen, A C, Leeming, D J, Mortensen, J H & Karsdal, M A 2022, ' An MMP-degraded and cross-linked fragment of type III collagen as a non-invasive biomarker of hepatic fibrosis resolution ', Liver International, vol. 42, no. 7, pp. 1605-1617 . https://doi.org/10.1111/liv.15270
Background and Aims: Liver fibrosis results from a prolonged wound healing response to continued injury with excessive production of extracellular proteins. In patients with chronic liver disease, the monitoring of liver fibrosis dynamics is of high
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee5bb795f38b63bce37cfe522ee5cdc4
https://curis.ku.dk/portal/da/publications/an-mmpdegraded-and-crosslinked-fragment-of-type-iii-collagen-as-a-noninvasive-biomarker-of-hepatic-fibrosis-resolution(82cc768a-6c64-49d1-8a6d-5b5ed491575b).html
https://curis.ku.dk/portal/da/publications/an-mmpdegraded-and-crosslinked-fragment-of-type-iii-collagen-as-a-noninvasive-biomarker-of-hepatic-fibrosis-resolution(82cc768a-6c64-49d1-8a6d-5b5ed491575b).html