Zobrazeno 1 - 10
of 245
pro vyhledávání: '"Joachim GRÖTZINGER"'
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103309- (2021)
Summary: Blocking the activity of cytokines is an efficient strategy to combat inflammatory diseases. Interleukin-6 (IL-6) fulfills its pro-inflammatory properties via its soluble receptor (IL-6 trans-signaling). The selective trans-signaling inhibit
Externí odkaz:
https://doaj.org/article/b3dee9db303a4a72ae6b113f86f759f1
Autor:
Anne-Kathrin Bartels, Sascha Göttert, Christine Desel, Miriam Schäfer, Sebastian Krossa, Axel J. Scheidig, Joachim Grötzinger, Inken Lorenzen
Publikováno v:
Cellular Physiology and Biochemistry, Vol 52, Iss 4, Pp 850-868 (2019)
Externí odkaz:
https://doaj.org/article/a28e77e5e8e347c889c007c50f6e04be
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 5, Pp 2071-2085 (2018)
Background/Aims: The cytokine interleukin-11 (IL-11) has important pro- and anti-inflammatory functions. It activates its target cells through binding to the IL-11 receptor (IL-11R), and the IL-11/IL-11R complex recruits a homodimer of glycoprotein 1
Externí odkaz:
https://doaj.org/article/95bfaf6a59ec4a05b30c9d14cfab9c34
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018)
Abstract A Disintegrin and Metalloprotease 17 (ADAM17) can cause the fast release of growth factors and inflammatory mediators from the cell surface. Its activity has to be turned on which occurs by various stimuli. The active form can be inactivated
Externí odkaz:
https://doaj.org/article/8e0352618ebd453ea2b6906d705d91f7
Autor:
René Augustin, Katja Schröder, Andrea P. Murillo Rincón, Sebastian Fraune, Friederike Anton-Erxleben, Eva-Maria Herbst, Jörg Wittlieb, Martin Schwentner, Joachim Grötzinger, Trudy M. Wassenaar, Thomas C. G. Bosch
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)
Certain neuropeptides, in addition to their neuromodulatory functions, display antibacterial activities of unclear significance. Here, the authors show that a secreted neuropeptide modulates the distribution of bacterial communities on the body surfa
Externí odkaz:
https://doaj.org/article/b06c2c46e7bd4744804e80fc8a25bed4
Autor:
Juliane Lokau, Florian Kleinegger, Yvonne Garbers, Georg H Waetzig, Joachim Grötzinger, Stefan Rose-John, Johannes Haybaeck, Christoph Garbers
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232612 (2020)
Tocilizumab is a humanized monoclonal antibody that is approved for the treatment of different human inflammatory diseases, including rheumatoid arthritis and cytokine release syndrome. Tocilizumab binds to the interleukin-6 receptor (IL-6R) and ther
Externí odkaz:
https://doaj.org/article/5db749b22fd241da932fe66822a64c9f
Autor:
Anselm Sommer, Felix Kordowski, Joscha Büch, Thorsten Maretzky, Astrid Evers, Jörg Andrä, Stefan Düsterhöft, Matthias Michalek, Inken Lorenzen, Prasath Somasundaram, Andreas Tholey, Frank D. Sönnichsen, Karl Kunzelmann, Lena Heinbockel, Christian Nehls, Thomas Gutsmann, Joachim Grötzinger, Sucharit Bhakdi, Karina Reiss
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
ADAM17 is a member of the ‘Disintegrin and Metalloproteinase’ family of proteases, that cleaves transmembrane substrates from the surfaces of cells. Here the authors show that surface exposure of phosphatidylserine is required for ADAM17 sheddase
Externí odkaz:
https://doaj.org/article/7d870aa38fd548259ffdc80c22adca2f
Autor:
Yesenia Machado-Pineda, Beatriz Cardeñes, Raquel Reyes, Soraya López-Martín, Víctor Toribio, Paula Sánchez-Organero, Henar Suarez, Joachim Grötzinger, Inken Lorenzen, María Yáñez-Mó, Carlos Cabañas
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Integrin α5β1 is a crucial adhesion molecule that mediates the adherence of many cell types to the extracellular matrix through recognition of its classic ligand fibronectin as well as to other cells through binding to an alternative counter-recept
Externí odkaz:
https://doaj.org/article/cab31f90e55f462aa23787ab1c6d5c95
Autor:
Maria Agthe, Julian Brügge, Yvonne Garbers, Marieke Wandel, Birte Kespohl, Philipp Arnold, Charlotte M. Flynn, Juliane Lokau, Samadhi Aparicio-Siegmund, Christian Bretscher, Stefan Rose-John, Georg H. Waetzig, Tracy Putoczki, Joachim Grötzinger, Christoph Garbers
Publikováno v:
Cell Reports, Vol 25, Iss 1, Pp 10-18.e5 (2018)
Summary: Premature closure of the sutures that connect the cranial bones during development of the mammalian skull results in a phenotype called craniosynostosis. Recently, several craniosynostosis patients with missense mutations within the gene enc
Externí odkaz:
https://doaj.org/article/a5e04e6be0b747889149d6367b2b4483
Autor:
Steffen Riethmueller, Prasath Somasundaram, Johanna C Ehlers, Chien-Wen Hung, Charlotte M Flynn, Juliane Lokau, Maria Agthe, Stefan Düsterhöft, Yijue Zhu, Joachim Grötzinger, Inken Lorenzen, Tomas Koudelka, Kosuke Yamamoto, Ute Pickhinke, Rielana Wichert, Christoph Becker-Pauly, Marisa Rädisch, Alexander Albrecht, Markus Hessefort, Dominik Stahnke, Carlo Unverzagt, Stefan Rose-John, Andreas Tholey, Christoph Garbers
Publikováno v:
PLoS Biology, Vol 15, Iss 1, p e2000080 (2017)
Signaling of the cytokine interleukin-6 (IL-6) via its soluble IL-6 receptor (sIL-6R) is responsible for the proinflammatory properties of IL-6 and constitutes an attractive therapeutic target, but how the sIL-6R is generated in vivo remains largely
Externí odkaz:
https://doaj.org/article/0de46d7cf5e847c6bf5e71b31996514a