Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joachim Fruebis"'
Publikováno v:
Journal of Lipid Research, Vol 40, Iss 11, Pp 1958-1966 (1999)
We previously established that probucol decreases basal expression of VCAM-1 in the aorta of WHHL rabbits and inhibits the up-regulation of VCAM-1 expression that normally accompanies atherogenesis. To determine whether this effect is shared by other
Externí odkaz:
https://doaj.org/article/89233a49211d4857bb28c24613aa542a
Autor:
David A. Bird, Rajendra K. Tangirala, Joachim Fruebis, Daniel Steinberg, Joseph L. Witztum, Wulf Palinski
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 5, Pp 1079-1090 (1998)
Probucol is a powerful inhibitor of atherosclerosis in a number of animal models. However, it is unknown whether this is due to the strong antioxidant protection of low density lipoprotein (LDL), to antioxidant effects in the artery wall, or to cellu
Externí odkaz:
https://doaj.org/article/0fb8d8e4b6734921914a79e7676b8e37
Autor:
Bent Winding, Keiji Nogami, Guy Young, Chris Barnes, Huixing Yuan, Johannes Oldenburg, Elena Santagostino, Liane Khoo, Beatrice Nolan, Barbara A. Konkle, Joachim Fruebis, K. John Pasi, Ingrid Pabinger, Dan Rudin, Johnny Mahlangu
Publikováno v:
Haemophilia
Introduction The efficacy and safety of recombinant factor VIII Fc fusion protein (rFVIIIFc) as an extended half‐life treatment for severe haemophilia A were demonstrated in the Phase 3 A‐LONG and Kids A‐LONG studies. Eligible subjects who comp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4022ccca7aa7b264ac7e5d898662bf
http://europepmc.org/articles/PMC7384031
http://europepmc.org/articles/PMC7384031
Autor:
Yoshitaka Miyakawa, Bernd Jilma, Shirley D'Sa, Catherine Broome, Xiaoyu Jiang, Tor Henrik Anderson Tvedt, Joachim Fruebis, Wilma Barcellini, Stella Lin, Alexander Röth, Sigbjørn Berentsen, Jaime Morales-Arias, David J. Kuter, Marc Michel, Caroline Reuter, William Hobbs
Publikováno v:
The New England journal of medicine. 384(14)
Cold agglutinin disease is a rare autoimmune hemolytic anemia characterized by hemolysis that is caused by activation of the classic complement pathway. Sutimlimab, a humanized monoclonal antibody, selectively targets the C1s protein, a C1 complex se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a702164368e9867e94bab8aa83edb1b1
https://pubmed.ncbi.nlm.nih.gov/33826820
https://pubmed.ncbi.nlm.nih.gov/33826820
Autor:
Barbara A. Konkle, Amy D. Shapiro, Doris V. Quon, Janice M. Staber, Roshni Kulkarni, Margaret V. Ragni, Ekta S. Chhabra, Stacey Poloskey, Kara Rice, Suresh Katragadda, Dan Rudin, Joachim Fruebis, Craig C. Benson
Publikováno v:
The New England journal of medicine. 383(11)
Factor VIII replacement products have improved the care of patients with hemophilia A, but the short half-life of these products affects the patients' quality of life. The half-life of recombinant factor VIII ranges from 15 to 19 hours because of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fc9bfd6c1827d930d9d8a080f846cce
https://pubmed.ncbi.nlm.nih.gov/32905683
https://pubmed.ncbi.nlm.nih.gov/32905683
Autor:
Roshni Kulkarni, Johannes Oldenburg, Johnny Mahlangu, Hervé Chambost, Beatrice Nolan, Stephanie P’Ng, Carolyn M. Bennett, Margareth C. Ozelo, K. John Pasi, Bent Winding, Amy D. Shapiro, Huixing Yuan, Margaret V. Ragni, Joachim Fruebis, Tadashi Matsushita, Dan Rudin, Krista Fischer
Publikováno v:
Haemophilia
Haemophilia, Wiley, 2020, 26 (6), ⟨10.1111/hae.14036⟩
Haemophilia, 2020, 26 (6), ⟨10.1111/hae.14036⟩
Haemophilia, Wiley, 2020, 26 (6), ⟨10.1111/hae.14036⟩
Haemophilia, 2020, 26 (6), ⟨10.1111/hae.14036⟩
International audience; Introduction Recombinant factor IX Fc fusion protein (rFIXFc) has demonstrated efficacy for treatment of haemophilia B in the Phase 3 B-LONG and Kids B-LONG studies. However, long-term rFIXFc safety and efficacy data have not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cd16c5a39de08d060e95abeadfcd587
https://doi.org/10.1111/hae.14036
https://doi.org/10.1111/hae.14036
Autor:
Paul Sheppard, Ken Lewis, José A. López, Paul D. Bishop, Prasenjit Guchhait, Joachim Fruebis, Gerald W. Lasser, Miguel A. Cruz, Jeff L. Ellsworth
Publikováno v:
Blood. 107:423-430
CTRP-1 is a novel member of the C1qTNF–related protein family containing family characteristic collagen and TNF-like domains and shows marked expression in vascular wall tissue. We observed that recombinant human CTRP-1 specifically bound to fibril
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba5b0029e5d9c2dead596c3d9efa6cac
https://doi.org/10.1182/blood-2005-04-1425
https://doi.org/10.1182/blood-2005-04-1425
Autor:
Travis B. Smith, Mark E. Pennesi, Keith V. Michaels, Shu Feng, Trevor J. McGill, Jonathan D. Fay, Alison R. Weiss, Martha Neuringer, Anupam Garg, Marvin Sperling, Anda Cornea, Laurie Renner, Joachim Fruebis, Kay D. Rittenhouse, Sawan Hurst
Publikováno v:
Retinal Degenerative Diseases ISBN: 9781461432081
The aim of this study was to assess the feasibility of using a commercially available high-resolution adaptive optics (AO) camera to image the cone mosaic in Japanese macaques (Macaca fuscata) with dominantly inherited drusen. The macaques examined d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4dd8b18ab76c6f3e9c7d28235bfdf0c5
https://doi.org/10.1007/978-1-4614-3209-8_39
https://doi.org/10.1007/978-1-4614-3209-8_39
Autor:
Tsu-Shuen Tsao, Bernard Bihain, Dana Ebbets-Reed, Joachim Fruebis, Sandrine Javorschi, Frances T. Yen, Harvey F. Lodish, Mary Ruth Erickson
Publikováno v:
Proceedings of the National Academy of Sciences. 98:2005-2010
Adipocyte complement-related protein (30 kDa) (Acrp30), a secreted protein of unknown function, is exclusively expressed in differentiated adipocytes; its mRNA is decreased in obese humans and mice. Here we describe novel pharmacological properties o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07466a4e705ec08f3fb566a73be331c
https://doi.org/10.1073/pnas.98.4.2005
https://doi.org/10.1073/pnas.98.4.2005
Publikováno v:
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences. 55:B85-B94
Although age is a strong risk factor for atherosclerosis, it is unclear whether age may directly influence the process of atherogenesis. We, therefore, performed several studies in young (2-4 months old), mature (10-14 months old), and old (20-22 mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2805ffd37c9b397b800852eefadce7a4
https://doi.org/10.1093/gerona/55.2.b85
https://doi.org/10.1093/gerona/55.2.b85