Inducible deletion of skeletal muscle AMPKα reveals that AMPK is required for nucleotide balance but dispensable for muscle glucose uptake and fat oxidation during exercise

Autor: Janne R. Hingst, Rasmus Kjøbsted, Jesper B. Birk, Nicolas O. Jørgensen, Magnus R. Larsen, Kohei Kido, Jeppe Kjærgaard Larsen, Sasha A.S. Kjeldsen, Joachim Fentz, Christian Frøsig, Stephanie Holm, Andreas M. Fritzen, Tine L. Dohlmann, Steen Larsen, Marc Foretz, Benoit Viollet, Peter Schjerling, Peter Overby, Jens F. Halling, Henriette Pilegaard, Ylva Hellsten, Jørgen F.P. Wojtaszewski

Publikováno v: Molecular Metabolism, Vol 40, Iss , Pp 101028- (2020)

Objective: Evidence for AMP-activated protein kinase (AMPK)-mediated regulation of skeletal muscle metabolism during exercise is mainly based on transgenic mouse models with chronic (lifelong) disruption of AMPK function. Findings based on such model

Externí odkaz: https://doaj.org/article/7b639b94cb3449f3af4191459a29d7c6

Effect of long-term voluntary exercise wheel running on susceptibility to bacterial pulmonary infections in a mouse model.

Autor: Pauline B van de Weert-van Leeuwen, Angélica M M de Vrankrijker, Joachim Fentz, Oana Ciofu, Jørgen F P Wojtaszewski, Hubertus G M Arets, Hendrikus J Hulzebos, Cornelis K van der Ent, Jeffrey M Beekman, Helle K Johansen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e82869 (2013)

Regular moderate exercise has been suggested to exert anti-inflammatory effects and improve immune effector functions, resulting in reduced disease incidence and viral infection susceptibility. Whether regular exercise also affects bacterial infectio

Externí odkaz: https://doaj.org/article/084af9483f9647a793a589e1a43a9c64

Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle

Autor: David E. James, Benjamin L. Parker, Jesper B. Birk, Lea Bruhn, Marie F. Rosschou, Nils J. Færgeman, Kei Sakamoto, Joachim Fentz, Mads B. Hansen, Erik A. Richter, Bente Kiens, Marc Foretz, Jørgen F. P. Wojtaszewski, Janne R. Hingst, Jesper F. Havelund, Benoit Viollet, Jørgen Arendt Jensen

Publikováno v: Molecular metabolism
Molecular metabolism, Elsevier, 2018, 16, pp.24-34. ⟨10.1016/j.molmet.2018.07.001⟩
Molecular Metabolism, Vol 16, Iss, Pp 24-34 (2018)
Hingst, J R, Bruhn, L, Hansen, M B, Rosschou, M F, Birk, J B, Fentz, J, Foretz, M, Viollet, B, Sakamoto, K, Færgeman, N J, Havelund, J F, Parker, B L, James, D E, Kiens, B, Richter, E A, Jensen, J & Wojtaszewski, J F P 2018, ' Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle ', Molecular Metabolism, vol. 16, pp. 24-34 . https://doi.org/10.1016/j.molmet.2018.07.001
Hingst, J R, Bruhn, L, Hansen, M B, Rosschou, M F, Birk, J B, Fentz, J, Foretz, M, Viollet, B, Sakamoto, K, Færgeman, N J, Havelund, J F, Parker, B L, James, D E, Kiens, B, Richter, E A, Jensen, J & Wojtaszewski, J 2018, ' Exercise-induced molecular mechanisms promoting glycogen supercompensation in human skeletal muscle ', Molecular Metabolism, vol. 16, pp. 24-34 . https://doi.org/10.1016/j.molmet.2018.07.001

Objective: A single bout of exercise followed by intake of carbohydrates leads to glycogen supercompensation in prior exercised muscle. Our objective was to illuminate molecular mechanisms underlying this phenomenon in skeletal muscle of man. Methods

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cf8ecdbb54702daeab6b41d68b7fb54
https://hal.archives-ouvertes.fr/hal-02348845

Prior AICAR Stimulation Increases Insulin Sensitivity in Mouse Skeletal Muscle in an AMPK-Dependent Manner

Autor: Jesper B. Birk, Jørgen F. P. Wojtaszewski, Peter Schjerling, Joachim Fentz, Juleen R. Zierath, Benoit Viollet, Rasmus Kjøbsted, Louise Lantier, Marie Björnholm, Jonas T. Treebak

Publikováno v: Diabetes. 64:2042-2055

An acute bout of exercise increases glucose uptake in skeletal muscle by an insulin-independent mechanism. In the period after exercise, insulin sensitivity to increased glucose uptake is enhanced. The molecular mechanisms underpinning this phenomeno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5be0ec022df2070f02283c32112f8887
https://doi.org/10.2337/db14-1402

Insulin and IGF-1 receptors regulate FoxO-mediated signaling in muscle proteostasis

Autor: Megan T. Krumpoch, C. Ronald Kahn, Matthew M. Robinson, Michael F. Hirshman, Kevin Y. Lee, K. Sreekumaran Nair, Domenico Accili, Kristin I. Stanford, André Kleinridders, E. Dale Abel, Laurie J. Goodyear, Joachim Fentz, Katherine A. Klaus, Renata O. Pereira, Weikang Cai, Samir Softic, Brian T. O’Neill

Publikováno v: The journal of clinical investigation, 126(9): 3433-3446

Diabetes strongly impacts protein metabolism, particularly in skeletal muscle. Insulin and IGF-1 enhance muscle protein synthesis through their receptors, but the relative roles of each in muscle proteostasis have not been fully elucidated. Using mic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749008f16ac6bdcf8ff61485746e1f73
https://www.jci.org/articles/view/86522#sd