Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Joachim E. Roehr"'
Autor:
Kent W. Neuenschwander, Anthony C. Scotese, Larry Davis, Joachim E. Roehr, Shannon Dwyer, Neil Moorcroft, Zhongli Gao, Andrew Giovanni
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 23:1498-1501
A series of tetrahydroisoquinolines were designed, synthesized and evaluated as the first non-natural product type of compounds with dual D1 receptor (D1R) agonism and D2 receptor (D2R) antagonism properties for treatment of schizophrenia. The initia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88f3a68c194c193169d93c944ef86205
https://doi.org/10.1016/j.bmcl.2012.12.046
https://doi.org/10.1016/j.bmcl.2012.12.046
Autor:
Gregory M. Shutske, Joachim E. Roehr
Publikováno v:
Journal of Heterocyclic Chemistry. 34:789-795
A number of 3-substituted 6-piperazinylpyrazolo[3,4-b]pyridines were synthesized from 2,6-difluoropyridine by directed ortho metallation and sequential intra- and intermolecular displacement of fluorine. Three derivatives with a cyano group in the 3-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bae61c0d81f1924a91d8b0f2e31f05c3
https://doi.org/10.1002/jhet.5570340314
https://doi.org/10.1002/jhet.5570340314
Autor:
Jidong Cai, Sathapana Kongsamut, Lei Tang, Lisa L. Kerman, Joachim E. Roehr, Anthony Sandrasagra, Paul Weissensee, Harold B. Hartman
Publikováno v:
European Journal of Pharmacology. 317:417-423
Iloperidone (HP 873; 1-[4-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone) is a compound currently in clinical trials for the treatment of schizophrenia. Iloperidone displays affinity for dopamine D 2 receptors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32649c911c21c91c2d35d382299afcd5
https://doi.org/10.1016/s0014-2999(96)00840-0
https://doi.org/10.1016/s0014-2999(96)00840-0
Autor:
Roy Corbett, Wayne W. Petko, Gina M. Bores, Ann T. Woods-Kettelberger, Sathapana Kongsamut, Craig P. Smith, Joachim E. Roehr, Susan M. Chesson
Publikováno v:
Neurochemical Research. 21:575-583
Examination of HP 184, [N-n-propyl)-N-(3-fluoro-4-pyridinyl) -1H-3-methylindodel-1-amine hydrochloride], in a variety of tests for serotonergic activity revealed some unique properties of this compound. We report here that 100 microM HP 184 enhanced
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b213d4ae8d16fe74ee9237f46982fd62
https://doi.org/10.1007/bf02527756
https://doi.org/10.1007/bf02527756
Autor:
Sam Kongsamut, Deborah E. Bregna, Lisa L. Kerman, Joachim E. Roehr, ‡ and Ann T. Woods-Kettelberger, Mark R. Szewczak, Harold B. Hartman, Jurcak John G, Roy Corbett, Hrib Nicholas J, Kendra L. Burgher, Sharon H. Kafka
Publikováno v:
Journal of Medicinal Chemistry. 39:4044-4057
HP-236 (3-[4-[4-(6-Fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2,5,5- trimethyl-4-thiazolidinone maleate; P-9236) (54) displayed a pharmacological profile indicative of potential atypical antipsychotic activity. A series of piperazinyl butyl thiaz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70f34f27b11f91b1bf373c26201d52ba
https://doi.org/10.1021/jm960268u
https://doi.org/10.1021/jm960268u
Publikováno v:
European Journal of Pharmacology. 278:75-78
Schedule-induced polydipsia was induced when food-deprived rats were subjected to a fixed-time (60 s) feeding schedule for 150 min daily for 3 weeks (training period). Subsequent chronic administration of the serotonin reuptake inhibitor fluoxetine r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::325f2c02b1dd0a7f4ffe25710d917462
https://doi.org/10.1016/0014-2999(95)00099-7
https://doi.org/10.1016/0014-2999(95)00099-7
Autor:
Paul G. Conway, Joachim E. Roehr, Kendra L. Burgher, Jurcak John G, L. L. Kerman, Harold B. Hartman, Hrib Nicholas J, Woods Ann Theresa
Publikováno v:
Journal of Medicinal Chemistry. 37:2308-2314
A series of benzisoxaazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D 2 and serotonin 5HT 2A and 5HT 1A receptors. Several members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c19b10bad7a6db7d13bbed8e553a51f
https://doi.org/10.1021/jm00041a009
https://doi.org/10.1021/jm00041a009
Autor:
Richard C. Effland, Craig P. Smith, Joseph Thomas Klein, Joachim E. Roehr, Sathapana Kongsamut, Wayne W. Petko, Francis P. Huger
Publikováno v:
Drug Development Research. 32:13-18
N-(n-propyl)-N-(4-pyridinyl)-1H-indol-1-amine (HP 749) is currently in clinical trials for the treatment of Alzheimer's disease (AD). While HP 749 has many pharmacological properties, the biochemical basis for its efficacy in animal models for AD rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3713eb419a4c12a5880dfd4177b7e0c6
https://doi.org/10.1002/ddr.430320104
https://doi.org/10.1002/ddr.430320104
Autor:
Paul G. Conway, Joachim E. Roehr, Hrib Nicholas J, L. L. Kerman, Kendra L. Burgher, Jurcak John G, Woods Ann Theresa, Harold B. Hartman
Publikováno v:
ChemInform. 25
A series of benzisoxaazole- and benzisothiazole-3-carboxamides has been prepared and tested for potential antipsychotic activity. In general, the compounds showed an affinity for dopamine D 2 and serotonin 5HT 2A and 5HT 1A receptors. Several members
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::02112b01fc223667afdc88ea96b60e59
https://doi.org/10.1002/chin.199451169
https://doi.org/10.1002/chin.199451169
Autor:
Mark R. Szewczak, H. B. Hartmann, S. Kongsamut, L. L. Kerman, A. T. Woods-Kettelberger, R. Corbett, Kendra L. Burgher, Jurcak John G, Hrib Nicholas J, D. E. Bregna, Joachim E. Roehr, S. Kafka
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d852ddf2afb7063c3006d371c15674ab
https://doi.org/10.1002/chin.199704180
https://doi.org/10.1002/chin.199704180