Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Joachim Dr. Hütter"'
Autor:
Tobias Heinrich, Roger Schibli, Bernhard Vos, P. August Schubiger, Marcus Bauser, Joachim Dr. Hütter, Adrienne Müller, Stefanie-Dorothea Krämer, Ludger Dinkelborg, Timo Stellfeld, Svetlana V. Selivanova, Jörg Meding, Simon M. Ametamey
Publikováno v:
Journal of Medicinal Chemistry. 56:4912-4920
The activity of matrix metalloproteinases (MMPs) is elevated locally under many pathological conditions. Gelatinases MMP2 and MMP9 are of particular interest because of their implication in angiogenesis, cancer cell proliferation and metastasis, and
Autor:
K Zimmermann, Heimo Ehmke, Heiner Apeler, Santiago Figueroa-Pérez, Mario Lobell, Mark-Jean Gnoth, Klaus Münter, J Lenz, Joachim Dr. Hütter, K H Augstein, Johannes-Peter Stasch, Hartmut Schirok, Andreas Knorr, J K Franz, Joachim Mittendorf, Raimund Kast
Publikováno v:
British Journal of Pharmacology. 152:1070-1080
Background and purpose: Rho-kinase (ROCK) has been implicated in the pathophysiology of altered vasoregulation leading to hypertension. Here we describe the pharmacological characterization of a potent, highly selective and orally active ROCK inhibit
Publikováno v:
International Journal of Impotence Research. 19:533-543
The phosphodiesterase type-5 (PDE5) inhibitors sildenafil, vardenafil and tadalafil are widely used first-line therapy for erectile dysfunction (ED). Since the advent of sildenafil in 1998, more than 40 million men worldwide have been successfully tr
Autor:
Emanuel Lohrmann, Cristina Alonso-Alija, Frank Wunder, Johannes-Peter Stasch, Joachim Dr. Hütter, Jörg Hüser
Publikováno v:
Analytical Biochemistry. 339:104-112
We have established a rapid, homogeneous, cell-based, and highly sensitive assay for guanosine 3'-5'-cyclic monophosphate (cGMP) that is suitable for fully automated ultra-high-throughput screening. In this assay system, cGMP production is monitored
Autor:
Joachim Dr. Hütter, Heike Heckroth, Joachim Mittendorf, Dieter Lang, Klaus Münter, Samir Bennabi, Achim Feurer, Mario Lobell, Martin Radtke, Volker Geiß, Holger Paulsen, Hartmut Schirok, Mark Jean Gnoth, Johannes-Peter Stasch, Michael Thutewohl, Andreas Knorr, Santiago Figueroa-Pérez, Heimo Ehmke, Raimund Kast
Publikováno v:
ChemMedChem. 3(12)
Rho kinase plays a pivotal role in several cellular processes such as vasoregulation, making it a suitable target for the treatment of hypertension and related disorders. We discovered a new compound class of Rho kinase (ROCK) inhibitors containing a
Autor:
Heike Heckroth, Johannes-Peter Stasch, Michael Thutewohl, Martin Radtke, Dieter Lang, Klaus Münter, Santiago Figueroa-Pérez, Heimo Ehmke, Achim Feurer, Mario Lobell, Samir Bennabi, Joachim Dr. Hütter, Joachim Mittendorf, Mark Jean Gnoth, Volker Geiß, Holger Paulsen, Raimund Kast, Hartmut Schirok, Andreas Knorr
Publikováno v:
ChemMedChem. 3:1797-1797
Publikováno v:
European Urology Supplements. 6:36