Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Joachim Degen"'
Autor:
Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-Ur Rahman, Wiesław Krzyżak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Scot Jackson
Publikováno v:
PLoS Biology, Vol 17, Iss 8, p e3000374 (2019)
A deep understanding of how regulation of the multiple levels of gene expression in mammalian tissues give rise to complex phenotypes has been impeded by cellular diversity. A handful of techniques were developed to tag-select nucleic acids of intere
Externí odkaz:
https://doaj.org/article/4d7f935293ea4f33a948b0ca84342831
Autor:
Andreas Bickert, Christina Ginkel, Matthijs Kol, Katharina vom Dorp, Holger Jastrow, Joachim Degen, René L. Jacobs, Dennis E. Vance, Elke Winterhager, Xian-Cheng Jiang, Peter Dörmann, Pentti Somerharju, Joost C.M. Holthuis, Klaus Willecke
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 821-835 (2015)
Besides bulk amounts of SM, mammalian cells produce small quantities of the SM analog ceramide phosphoethanolamine (CPE). Little is known about the biological role of CPE or enzymes responsible for CPE production. Heterologous expression studies reve
Externí odkaz:
https://doaj.org/article/b55343a153c440909b926aa8cdb55ae3
Autor:
Oliver Tress, Marta Maglione, Armin Zlomuzica, Dennis May, Nikolai Dicke, Joachim Degen, Ekrem Dere, Helmut Kettenmann, Dieter Hartmann, Klaus Willecke
Publikováno v:
PLoS Genetics, Vol 7, Iss 7, p e1002146 (2011)
Gap junction channels are intercellular conduits that allow diffusional exchange of ions, second messengers, and metabolites. Human oligodendrocytes express the gap junction protein connexin47 (Cx47), which is encoded by the GJC2 gene. The autosomal
Externí odkaz:
https://doaj.org/article/8c5580de9b074600841a02b4205d381a
Autor:
Lech Kaczmarczyk, Vikas Bansal, Ashish Rajput, Raza-ur Rahman, Wiesław Krzyżak, Joachim Degen, Stefanie Poll, Martin Fuhrmann, Stefan Bonn, Walker Scot Jackson
Publikováno v:
PLOS Biology. 20:e3001882
Autor:
Andreas Bickert, Stefanie Herresthal, Dieter Hartmann, Martina van Uelft, Reinhard Bauer, Joachim Degen, Peter Dörmann, Konrad Sandhoff, Thomas Ulas, Klaus Willecke, Paul Kern, Bernadette Breiden, Katharina Gutbrod, Joachim L. Schultze
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1863:734-749
The replacement of two consecutive histidine residues by alanine residues in the catalytic center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to inactivation of catalytic activity and reduces protein level to 60% of the
Autor:
Katharina vom Dorp, Philipp S. Jäger, Peter Dörmann, Michael Hoch, Anne C. Carstensen, Joachim Degen, Dominic Gosejacob, Martin Frejno, Monika Köhnke
Publikováno v:
Journal of Biological Chemistry. 291:6989-7003
Ceramides are bioactive sphingolipids, which are composed of sphingoid bases carrying acyl chains of various lengths. Ceramides are synthesized by a family of six ceramide synthases (CerS) in mammals, which produce ceramides with different N-linked a
Autor:
Hany Farwanah, Konrad Sandhoff, Mariona Rabionet, Klaus Willecke, Christina Ginkel, Roger Sandhoff, Armin Zlomuzica, Ekrem Dere, Katharina vom Dorp, Joachim Degen, Dieter Hartmann, Matthias Eckhardt, Peter Dörmann
Publikováno v:
Journal of Biological Chemistry. 287:41888-41902
Ceramide synthase 1 (CerS1) catalyzes the synthesis of C18 ceramide and is mainly expressed in the brain. Custom-made antibodies to a peptide from the C-terminal region of the mouse CerS1 protein yielded specific immunosignals in neurons but no other
Autor:
Stephanie Griemsmann, Gerald Seifert, Joachim Degen, Christian Steinhäuser, Helmut Kettenmann, Peter Bedner, Martin Theis, Anna Beinhauer, Elena von Staden, Klaus Willecke, Jiong Zhang, Vincenzo Crunelli, Pavel Dublin, Simon P. Höft, Nadine Richter, Ronald Jabs, David W. Cope
The thalamus plays important roles as a relay station for sensory information in the central nervous system (CNS). Although thalamic glial cells participate in this activity, little is known about their properties. In this study, we characterized the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2885e9afec46d9d006da04d44b857994
Autor:
Konrad Sandhoff, Dieter Hartmann, Joachim Degen, Roger Sandhoff, Volkmar Gieselmann, Hany Farwanah, Silke Imgrund, Klaus Willecke, Matthias Eckhardt
Publikováno v:
Journal of Biological Chemistry; Vol 284
Journal of Biological Chemistry
Journal of Biological Chemistry
(Dihydro)ceramide synthase 2 (cers2, formerly called lass2) is the most abundantly expressed member of the ceramide synthase gene family, which includes six isoforms in mice. CERS2 activity has been reported to be specific toward very long fatty acid
Autor:
Stijn van Dorp, Elke C. Fuchs, Sebastiaan K. E. Koekkoek, Kerstin Wellershaus, Bjorn R. Dortland, Marcel T. G. de Jeu, Sara Khosrovani, Chris I. De Zeeuw, Hannah Monyer, Ruben S. Van Der Giessen, Klaus Willecke, Alexander Cupido, Jornt R. De Gruijl, Joachim Degen, Jim Deuchars
Publikováno v:
Neuron, 58(4), 599-612. Cell Press
SummaryThe level of electrotonic coupling in the inferior olive is extremely high, but its functional role in cerebellar motor control remains elusive. Here, we subjected mice that lack olivary coupling to paradigms that require learning-dependent ti