Výsledky vyhledávání - "Joachim C. Burbiel"

Akademický článek

Microwave-assisted ring closure reactions: Synthesis of 8-substituted xanthine derivatives and related pyrimido- and diazepinopurinediones

Autor: Joachim C. Burbiel, Jörg Hockemeyer, Christa E. Müller

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 2, Iss 1, p 20 (2006)

BackgroundPoly-substituted xanthine derivatives are an important class of compounds in medicinal chemistry. Substitution at the 8-position of the purine ring is generally accessible by ring closure of a carboxamido-substituted uracil precursor. Altho

Externí odkaz: https://doaj.org/article/e1e4f849360e40f79e1450e58f9d43a8

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2-Amino[1,2,4]triazolo[1,5-c]quinazolines and Derived Novel Heterocycles: Syntheses and Structure-Activity Relationships of Potent Adenosine Receptor Antagonists

Autor: Joachim C. Burbiel, Rajan S. Kombu, Anna-Maria Herzner, Jörg Hockemeyer, Christa E. Müller, Svenja K. Lacher, Wadih Ghattas, Petra Küppers, Meryem Köse, Raghuram Rao Akkinepally

Publikováno v: ChemMedChem. 11:2272-2286

2-Amino[1,2,4]triazolo[1,5-c]quinazolines were identified as potent adenosine receptor (AR) antagonists. Synthetic strategies were devised to gain access to a broad range of derivatives including novel polyheterocyclic compounds. Potent and selective

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193535bf01b80fc82150e6a3546b39c4
https://doi.org/10.1002/cmdc.201600255

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P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction

Autor: Joachim C. Burbiel, Kerstin Troidl, Jon O. Lundberg, Harmandeep Kaur, Stefan Offermanns, Julián Albarrán Juárez, András Iring, Nina Wettschureck, Shengpeng Wang, Sarah Tonack, Boris Strilic, Ingrid Fleming, Christa E. Müller

Publikováno v: Wang, S, Iring, A, Strilic, B, Juárez, J A, Kaur, H, Troidl, K, Tonack, S, Burbiel, J C, Müller, C E, Fleming, I, Lundberg, J O, Wettschureck, N & Offermanns, S 2015, ' P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction ' J. Clin. Invest. . https://doi.org/10.1172/jci81067

Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are released from the endothelium in response to fluid shear stress e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eb3acaa39b0f81b08db54e56fadffc
https://doi.org/10.1172/jci81067

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A novel receptor cross-talk between the ATP receptor P2Y2 and formyl peptide receptors reactivates desensitized neutrophils to produce superoxide

Autor: Huamei Forsman, Karin Christenson, Karin Önnheim, Claes Dahlgren, Tudor I. Oprea, Christa E. Müller, Johan Bylund, Joachim C. Burbiel, Michael Gabl

Publikováno v: Experimental Cell Research. 323:209-217

Neutrophils express several G-protein coupled receptors (GPCRs) and they cross regulate each other. We described a novel cross-talk mechanism in neutrophils, by which signals generated by the receptor for ATP (P2Y2) reactivate desensitized formyl pep

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9c17967539e9ff1bdf7a4c705c6d1c
https://doi.org/10.1016/j.yexcr.2014.01.023

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Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925

Autor: Isaac Yaw Attah, Joachim C. Burbiel, Muhammad Rafehi, Christa E. Müller, Aliaa Abdelrahman

The Gq protein-coupled, ATP- and UTP-activated P2Y2 receptor is a potential drug target for a range of different disorders, including tumor metastasis, inflammation, atherosclerosis, kidney disorders, and osteoporosis, but pharmacological studies are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebef861f24f824136b6aaca926df429f
https://europepmc.org/articles/PMC5334202/

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Focused screening to identify new adenosine kinase inhibitors

Autor: Christa E. Müller, Hans-Dietrich Stachel, Raghuram Rao Akkinepally, Hermann Poschenrieder, Anke C. Schiedel, Meryem Köse, Alexander Andreas Bauer, Joachim C. Burbiel

Publikováno v: Bioorganicmedicinal chemistry. 24(21)

Adenosine kinase (AdK) is a key player in controlling intra- and extracellular concentrations of the signaling molecule adenosine. Extensive evidence points to an important role of AdK in several diseases, and suggests that AdK inhibition might be a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228429293e080d845822edbf2d1a9ba0
https://pubmed.ncbi.nlm.nih.gov/27595538

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Cardiomyocyte death induced by ischaemic/hypoxic stress is differentially affected by distinct purinergic P2 receptors

Autor: Joachim C. Burbiel, Haijian Luo, Elena Tremoli, Maria P. Abbracchio, Simona Cosentino, Cristina Banfi

Publikováno v: Journal of Cellular and Molecular Medicine

Blood levels of extracellular nucleotides (e.g. ATP) are greatly increased during heart ischaemia, but, despite the presence of their specific receptors on cardiomyocytes (both P2X and P2Y subtypes), their effects on the subsequent myocardial damage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c8f5bdf2096f226fb6f3ec46bc0c9
https://doi.org/10.1111/j.1582-4934.2011.01382.x

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Recent Progress in the Development of Adenosine Receptor Ligands as Antiinflammatory Drugs

Autor: Joachim C. Burbiel, Christa E. Müller, Rhalid Akkari, Jörg Hockemeyer

Publikováno v: Current Topics in Medicinal Chemistry. 6:1375-1399

Adenosine receptors belong to the family of G protein-coupled receptors. Four distinct subtypes are known, termed A(1), A(2A), A(2B) and A(3). Adenosine is an important signaling molecule which is released under inflammatory conditions. It can show a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174e265d648321cd34e487c347986270
https://doi.org/10.2174/15680266106061375

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