Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Joachim C. Burbiel"'
Autor:
Joachim C. Burbiel
Publikováno v:
ARKIVOC, Vol 2006, Iss 13, Pp 16-21 (2006)
Externí odkaz:
https://doaj.org/article/dfd26f730f57479f9d804dc3e4aac5b4
Publikováno v:
ARKIVOC, Vol 2006, Iss 2, Pp 77-82 (2005)
Externí odkaz:
https://doaj.org/article/9e2011095b0b4a329012ea004b22be24
Autor:
Joachim C. Burbiel, Rajan S. Kombu, Anna-Maria Herzner, Jörg Hockemeyer, Christa E. Müller, Svenja K. Lacher, Wadih Ghattas, Petra Küppers, Meryem Köse, Raghuram Rao Akkinepally
Publikováno v:
ChemMedChem. 11:2272-2286
2-Amino[1,2,4]triazolo[1,5-c]quinazolines were identified as potent adenosine receptor (AR) antagonists. Synthetic strategies were devised to gain access to a broad range of derivatives including novel polyheterocyclic compounds. Potent and selective
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::193535bf01b80fc82150e6a3546b39c4
https://doi.org/10.1002/cmdc.201600255
https://doi.org/10.1002/cmdc.201600255
Autor:
Joachim C. Burbiel, Kerstin Troidl, Jon O. Lundberg, Harmandeep Kaur, Stefan Offermanns, Julián Albarrán Juárez, András Iring, Nina Wettschureck, Shengpeng Wang, Sarah Tonack, Boris Strilic, Ingrid Fleming, Christa E. Müller
Publikováno v:
Wang, S, Iring, A, Strilic, B, Juárez, J A, Kaur, H, Troidl, K, Tonack, S, Burbiel, J C, Müller, C E, Fleming, I, Lundberg, J O, Wettschureck, N & Offermanns, S 2015, ' P2Y2 and Gq/G11 control blood pressure by mediating endothelial mechanotransduction ' J. Clin. Invest. . https://doi.org/10.1172/jci81067
Elevated blood pressure is a key risk factor for developing cardiovascular diseases. Blood pressure is largely determined by vasodilatory mediators, such as nitric oxide (NO), that are released from the endothelium in response to fluid shear stress e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27eb3acaa39b0f81b08db54e56fadffc
https://doi.org/10.1172/jci81067
https://doi.org/10.1172/jci81067
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 2, Iss 1, p 20 (2006)
BackgroundPoly-substituted xanthine derivatives are an important class of compounds in medicinal chemistry. Substitution at the 8-position of the purine ring is generally accessible by ring closure of a carboxamido-substituted uracil precursor. Altho
Externí odkaz:
https://doaj.org/article/e1e4f849360e40f79e1450e58f9d43a8
Autor:
Huamei Forsman, Karin Christenson, Karin Önnheim, Claes Dahlgren, Tudor I. Oprea, Christa E. Müller, Johan Bylund, Joachim C. Burbiel, Michael Gabl
Publikováno v:
Experimental Cell Research. 323:209-217
Neutrophils express several G-protein coupled receptors (GPCRs) and they cross regulate each other. We described a novel cross-talk mechanism in neutrophils, by which signals generated by the receptor for ATP (P2Y2) reactivate desensitized formyl pep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f9c17967539e9ff1bdf7a4c705c6d1c
https://doi.org/10.1016/j.yexcr.2014.01.023
https://doi.org/10.1016/j.yexcr.2014.01.023
The Gq protein-coupled, ATP- and UTP-activated P2Y2 receptor is a potential drug target for a range of different disorders, including tumor metastasis, inflammation, atherosclerosis, kidney disorders, and osteoporosis, but pharmacological studies are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebef861f24f824136b6aaca926df429f
https://europepmc.org/articles/PMC5334202/
https://europepmc.org/articles/PMC5334202/
Autor:
Christa E. Müller, Hans-Dietrich Stachel, Raghuram Rao Akkinepally, Hermann Poschenrieder, Anke C. Schiedel, Meryem Köse, Alexander Andreas Bauer, Joachim C. Burbiel
Publikováno v:
Bioorganicmedicinal chemistry. 24(21)
Adenosine kinase (AdK) is a key player in controlling intra- and extracellular concentrations of the signaling molecule adenosine. Extensive evidence points to an important role of AdK in several diseases, and suggests that AdK inhibition might be a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::228429293e080d845822edbf2d1a9ba0
https://pubmed.ncbi.nlm.nih.gov/27595538
https://pubmed.ncbi.nlm.nih.gov/27595538
Autor:
Joachim C. Burbiel, Haijian Luo, Elena Tremoli, Maria P. Abbracchio, Simona Cosentino, Cristina Banfi
Publikováno v:
Journal of Cellular and Molecular Medicine
Blood levels of extracellular nucleotides (e.g. ATP) are greatly increased during heart ischaemia, but, despite the presence of their specific receptors on cardiomyocytes (both P2X and P2Y subtypes), their effects on the subsequent myocardial damage
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::224c8f5bdf2096f226fb6f3ec46bc0c9
https://doi.org/10.1111/j.1582-4934.2011.01382.x
https://doi.org/10.1111/j.1582-4934.2011.01382.x
Publikováno v:
Current Topics in Medicinal Chemistry. 6:1375-1399
Adenosine receptors belong to the family of G protein-coupled receptors. Four distinct subtypes are known, termed A(1), A(2A), A(2B) and A(3). Adenosine is an important signaling molecule which is released under inflammatory conditions. It can show a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::174e265d648321cd34e487c347986270
https://doi.org/10.2174/15680266106061375
https://doi.org/10.2174/15680266106061375