Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Joachim Baumgart"'
Autor:
Claudia Thäte, Christiane Woischwill, Gunda Brandenburg, Matthias Müller, Sonja Böhm, Joachim Baumgart
Publikováno v:
Toxicology Reports, Vol 8, Iss , Pp 1960-1969 (2021)
Guidelines regulating the development of advanced therapy medicinal products (ATMPs) request nonclinical data for toxicity, biodistribution and tumorigenicity before mesenchymal stromal cell (MSC) products can be administered in large clinical trials
Externí odkaz:
https://doaj.org/article/86385dd8a2ad4d74bbb2a26777b6e766
Autor:
Tapani Ruutu, Liisa Volin, Dietrich W. Beelen, Rudolf Trenschel, Juergen Finke, Marc Schnitzler, Jerzy Holowiecki, Sebastian Giebel, Miroslaw Markiewicz, Lutz Uharek, Igor W. Blau, Joachim Kienast, Matthias Stelljes, Kajsa Larsson, Axel R. Zander, Martin Gramatzki, Roland Repp, Hermann Einsele, Gernot Stuhler, Joachim Baumgart, Heidrun A. Mylius, Uwe Pichlmeier, Mathias Freund, Jochen Casper
Publikováno v:
Haematologica, Vol 96, Iss 9 (2011)
Background An alternative reduced-toxicity conditioning regimen for allogeneic transplantation, based on treosulfan and fludarabine, has recently been identified. The rationale for this study was to investigate the efficacy and safety of this regimen
Externí odkaz:
https://doaj.org/article/03a7416fefd94f2c8b6d70e3b0f9c7c5
Autor:
Xieran Li, Krzysztof Kalwak, Rita Beier, Jochen Kehne, Ann-Kristin Möller, Joachim Baumgart, Dietrich W. Beelen, Ralf A. Hilger, Ajay Vora, Karl-Walter Sykora
Publikováno v:
Drug Metabolism and Pharmacokinetics. :100515
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a25078e5e2fd6f7aee7b1eced41778af
https://doi.org/10.1016/j.dmpk.2023.100515
https://doi.org/10.1016/j.dmpk.2023.100515
Autor:
Laurel A Thur, Jonathan A. Gutman, Eneida R. Nemecek, Colleen Delaney, Frederick R. Appelbaum, Joachim Baumgart, Rachel B. Salit, Ann Dahlberg, H. Joachim Deeg, Corinne Summers, Filippo Milano
Publikováno v:
Blood Adv
Although the use of treosulfan (TREO) in conventional donor hematopoietic cell transplantation (HCT) has been extensively evaluated, its use in cord blood transplantation (CBT) for hematologic malignancies has not been reported. Between March 2009 an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::316ec5b79aa6674173e0507144a19140
https://doi.org/10.1182/bloodadvances.2020002222
https://doi.org/10.1182/bloodadvances.2020002222
Autor:
Pavel Balazki, Sonja Böhm, Dietrich W. Beelen, Frederico Severino Martins, Stephan Schaller, Joachim Baumgart, Arne Ring, Ralf A. Hilger, Claudia Hemmelmann
Publikováno v:
British journal of clinical pharmacology. 88(4)
Aims: The aim of this work is the development of a mechanistic physiologically-based pharmacokinetic (PBPK) model using in vitro to in vivo extrapolation to conduct a drug-drug interaction (DDI) assessment of treosulfan against two cytochrome p450 (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::97b0d7bd430278c1a4bf5ab2f371ec4e
https://pubmed.ncbi.nlm.nih.gov/34519068
https://pubmed.ncbi.nlm.nih.gov/34519068
Autor:
Matthias Müller, Joachim Baumgart, Claudia Thäte, Gunda Brandenburg, Christiane Woischwill, Sonja Böhm
Publikováno v:
Toxicology Reports
Toxicology Reports, Vol 8, Iss, Pp 1960-1969 (2021)
Toxicology Reports, Vol 8, Iss, Pp 1960-1969 (2021)
Graphical abstract
Highlights • Good safety profile of mesenchymal stromal cells (MSCs) without toxicity findings. • MSC biodistribution showed primary distribution to the lung and short persistence. • No tumor formation observed after 6 m
Highlights • Good safety profile of mesenchymal stromal cells (MSCs) without toxicity findings. • MSC biodistribution showed primary distribution to the lung and short persistence. • No tumor formation observed after 6 m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f7154308587b884c5c495851c74f925
https://pubmed.ncbi.nlm.nih.gov/34926173
https://pubmed.ncbi.nlm.nih.gov/34926173
Autor:
Klaus Daniel Stachel, Katarzyna Drabko, Petr Sedlacek, Bernd Gruhn, Selim Corbacioglu, Jolanta Gozdzik, Krzysztof Kałwak, Peter Bader, Katharine Patrick, Franco Locatelli, Claudia Hemmelmann, Franca Fagioli, Joachim Baumgart, Paul G. Schlegel, Rita Beier, Jan Styczyński, Ann Kristin Möller, Johann Greil, Birgit Burkhardt, Ajay Vora, Karl Walter Sykora, Ingo Müller, Monika Mielcarek
Publikováno v:
Bone Marrow Transplantation
Treosulfan-based conditioning prior to allogeneic transplantation has been shown to have myeloablative, immunosuppressive, and antineoplastic effects associated with reduced non-relapse mortality (NRM) in adults. Therefore, we prospectively evaluated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a007f5355a53d871e1c9b2db18af740d
https://ruj.uj.edu.pl/xmlui/handle/item/263469
https://ruj.uj.edu.pl/xmlui/handle/item/263469
Autor:
Christian Junghanß, Christoph Groth, Nadezda Basara, Sandra Grass, Anja Klein, Inken Hilgendorf, Dietger Niederwieser, Sabine Dressler, Domenico Russo, Matthias Stelljes, Miroslaw Markiewicz, Beate Hauptrock, Daniel Wolff, Christof Scheid, Hélène Labussière-Wallet, Ernst Holler, Wichard Vogel, Peter Dreger, Kerstin Schaefer-Eckart, Heidrun A. Mylius, Goetz Ulrich Grigoleit, Maria Caterina Micò, Joachim Baumgart, Jochen Casper, Fabio Ciceri, Thomas Luft, Dietrich W. Beelen, Anna Paola Iori, Alessandro Rambaldi, Gernot Stuhler, Péter Reményi, Maria Bieniaszewska, Marta Medeot, Tamás Masszi, Nils Rudolf Winkelmann, Udo Holtick, Jacopo Peccatori, Uwe Pichlmeier, Mauricette Michallet, Friedrich Stölzel, Eva Maria Wagner-Drouet, Fabio Benedetti, Stephan Mielke, Johannes Schetelig, Régis Peffault de Latour, Wolfgang Bethge, Georg Nikolaus Franke, Michael Tribanek, Monika Dzierzak-Mietla, Helge Menzel, Gérard Socié, Rudolf Trenschel, Gerald Wulf, Bertram Glass, Christina Grosse-Thie, Mareike Verbeek, Juergen Finke, Francesca Patriarca, Claudia Hemmelmann
Background: Further improvement of preparative regimens before allogeneic haemopoietic stem cell transplantation (HSCT) is an unmet medical need for the growing number of older or comorbid patients with acute myeloid leukaemia or myelodysplastic synd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2d66fb7802e61a3fc010c0ad5e41e54
http://hdl.handle.net/11390/1173350
http://hdl.handle.net/11390/1173350
Publikováno v:
Drug Metabolism and Disposition. 43:1946-1954
Treosulfan (TREO) is currently investigated as an alternative treatment of busulfan in conditioning before hematopoietic stem cell transplantation. The knowledge of the blood-brain barrier penetration of the drug is still scarce. In this paper, penet
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38304a10f8e895255d9479363bbbc9fa
https://doi.org/10.1124/dmd.115.066050
https://doi.org/10.1124/dmd.115.066050
Autor:
Gunda Brandenburg, Joachim Baumgart, Sabine Poppenborg, Julia Wittmann, Ralf Krähmer, Frank Leenders, Wolfgang Walther
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 91
The potential impact of pre-existing anti-PEG antibodies on the asparaginase activity kinetics of two pegylated l-asparaginase preparations - pegylated recombinant l-asparaginase (PEG-rASNase MC0609) and pegaspargase (pegylated Escherichia colil-aspa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3729c7ea174c72e1f5825abe9e5ca70
https://pubmed.ncbi.nlm.nih.gov/27292820
https://pubmed.ncbi.nlm.nih.gov/27292820