Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Joachim Ramerstorfer"'
Autor:
Maxim N. Zhmak, Vladislav G. Starkov, Werner Sieghart, Irina V. Shelukhina, Yuri N. Utkin, Joachim Ramerstorfer, Dmitry A. Dolgikh, Ekaterina N. Lyukmanova, Elena V. Kryukova, Victor I. Tsetlin, Lina V. Son, Denis S. Kudryavtsev, Igor Ivanov, Lucy O. Ojomoko, Igor E. Kasheverov
Publikováno v:
Journal of Biological Chemistry. 290:22747-22758
Ionotropic receptors of γ-aminobutyric acid (GABAAR) regulate neuronal inhibition and are targeted by benzodiazepines and general anesthetics. We show that a fluorescent derivative of α-cobratoxin (α-Ctx), belonging to the family of three-finger t
Autor:
Michael L. Berger, Philippe Hermange, Verena Foppa, Robert H. Dodd, Simon Janody, Werner Sieghart, Hanna Thiery, Joachim Ramerstorfer
Publikováno v:
Current Medicinal Chemistry. 22:771-780
GABA A receptors are the major inhibitory neurotransmitter receptors in the central nervous system and are targets of clinically important drugs modulating GABA induced ion flux by interacting with distinct allosteric binding sites. ROD 185 is a prev
Autor:
Shengming Huang, Joachim Ramerstorfer, James M. Cook, Margot Ernst, Zdravko Varagic, Isabella Sarto-Jackson, Werner Sieghart, Sundari Rallapalli
Publikováno v:
British Journal of Pharmacology. 169:384-399
Background and Purpose GABAA receptors are the major inhibitory neurotransmitter receptors in the mammalian brain and the target of many clinically important drugs interacting with different binding sites. Recently, we demonstrated that CGS 9895 (2-(
Autor:
Zdravko Varagic, Werner Sieghart, Hanna Ng, Bryan L. Roth, James K. Rowlett, Joachim Ramerstorfer, James M. Cook, Ojas A. Namjoshi, Edward Merle Johnson, Yun Teng Johnson, Zhi-Jian Wang, Sundari Rallapalli, Samarpan Majumder
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:93-101
Selective modulation of specific benzodiazepine receptor (BzR) gamma amino butyric acid-A (GABAA) receptor ion channels has been identified as an important method for separating out the variety of pharmacological effects elicited by BzR-related drugs
Autor:
Vladislav G. Starkov, Sarah C. R. Lummis, Ngoc Anh Hoang, Daniel Bertrand, Andrew J. Thompson, Werner Sieghart, Igor E. Kasheverov, T. V. Andreeva, Maxim N. Zhmak, Joachim Ramerstorfer, Yuri N. Utkin, Elena V. Kryukova, Victor I. Tsetlin, Christoph Weise
Publikováno v:
Journal of Biological Chemistry; Vol 287
The Journal of Biological Chemistry
The Journal of Biological Chemistry
Background: Venoms from rare snake species may contain toxins of new structural or/and pharmacological types. Results: Amino acid sequence of the new polypeptide azemiopsin isolated from Azemiops feae viper venom was established, and its biological a
Publikováno v:
British Journal of Pharmacology. 166:476-485
GABAA receptors are the major inhibitory transmitter receptors in the brain. They are ligand-gated chloride channels composed of five subunits that can belong to different subunit classes. The existence of six α, three β, three γ, one δ, one e, o
Autor:
Werner Sieghart, Margot Ernst, Lindsay B. Hough, Joachim Ramerstorfer, Paul Hoerbelt, Jeffrey L. Thomson, Mark W. Fleck
Publikováno v:
Neuropharmacology. 108
Histamine is an important neurotransmitter that exerts its physiological actions through H1-4 metabotropic receptors in mammals. It also directly activates ionotropic GABAA receptor (GABAAR) β3 homooligomers and potentiates GABA responses in αβ he
Autor:
Bernd Kerschner, Leila Saiepour, Sarah L. Ramsden, Joachim Ramerstorfer, Stephen J. Moss, Verena Tretter, Robert J. Harvey, Hermann Schindelin, Kirsten Harvey, Hans Michael Maric, Werner Sieghart, Ivan Milenkovic
Publikováno v:
Journal of Biological Chemistry; Vol 286
The multifunctional scaffolding protein gephyrin is a key player in the formation of the postsynaptic scaffold at inhibitory synapses, clustering both inhibitory glycine receptors (GlyRs) and selected GABA(A) receptor (GABA(A)R) subtypes. We report a
Autor:
Cristina Wasowski, Roman Furtmueller, Mariel Marder, Alejandro C. Paladini, Werner Sieghart, Birgit Furtmueller, Sigismund Huck, Joachim Ramerstorfer
Publikováno v:
European Journal of Pharmacology. 591:142-146
6,3'-Dinitroflavone (6,3'-DNF) is a synthetic flavone derivative that exerts anxiolytic effects in the elevated plus maze. Based on the finding that this effect is blocked by Ro15-1788 (ethyl-8-fluoro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]
Publikováno v:
Journal of Neurochemistry. 96:983-995
Comparative models of GABA(A) receptors composed of alpha1 beta3 gamma2 subunits were generated using the acetylcholine-binding protein (AChBP) as a template and were used for predicting putative engineered cross-link sites between the alpha1 and the