Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Joachim Broeker"'
Autor:
Elisabeth Grondal, Jale Karolyi-Oezguer, Dorothea Rudolph, Juergen Ramharter, Gerhard Gmaschitz, Geraldine Garavel, Joachim Broeker, Nina Kerres, Julian E. Fuchs, Patrick Werni, Karin S. Hofbauer, Wolfgang Hela, Andreas Gollner, Harald Weinstabl, Darryl B. McConnell
Publikováno v:
Chemmedchem
Mouse double minute 2 (MDM2) is a main and direct inhibitor of the crucial tumor suppressor p53. Reports from initial clinical trials showed that blocking this interaction with a small‐molecule inhibitor can have great value in the treatment of can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e29056aa41d6f40f9c97336772a73804
https://doi.org/10.1002/cmdc.201800617
https://doi.org/10.1002/cmdc.201800617
Autor:
Andreas Mantoulidis, Daniel Gerlach, Matthias Treu, Jörg Rinnenthal, Irene Waizenegger, Heribert Arnhof, Joachim Broeker, Jason Phan, Alex G. Waterson, Stephan W. Fesik, Jesse J. Lipp, Fabio Savarese, Annette Machado, Hengyu Lu, Norbert Kraut, Christian Smethurst, Darryl B. McConnell, Mark Petronczki, Timothy P. Heffernan, Michael Gmachl, Francesca Trapani, Andreas Gollner, Joseph R. Daniele, Joseph R. Marszalek, Dorothea Rudolph, Christopher P. Vellano, Peter Ettmayer, Johannes Popow, Marco H. Hofmann
Publikováno v:
Cancer Research. 81:1271-1271
KRASG12C mutations are predominantly found in non-small cell lung cancer (NSCLC, 13%), in colorectal cancer (CRC, 3%), and with a lower prevalence in pancreatic ductal adenocarcinoma (PDAC, 1%). The amino acid exchange at position 12 from glycine to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bbdda807f85664794dd2b07fd2adbbf4
https://doi.org/10.1158/1538-7445.am2021-1271
https://doi.org/10.1158/1538-7445.am2021-1271
Publikováno v:
Tetrahedron: Asymmetry. 20:273-287
The applicability of five aryl substituted m-hydrobenzoin ethers already tested in the L-Selectride® mediated stereoselective reduction of phenylglyoxylates as open chain chiral auxiliaries was further investigated via the α-alkylation of propionat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::834d3dc036481badbb86f435899945d2
https://doi.org/10.1016/j.tetasy.2009.02.004
https://doi.org/10.1016/j.tetasy.2009.02.004
Publikováno v:
Tetrahedron: Asymmetry. 17:2413-2429
Five partly novel aryl substituted m-hydrobenzoins were synthesized and the corresponding desymmetrized hydrobenzoin ethers evaluated as open chain chiral auxiliaries in the L-Selectride® mediated stereoselective reduction of phenylglyoxylates, resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48e3f1bc4339b98b795c006f715a09ed
https://doi.org/10.1016/j.tetasy.2006.08.017
https://doi.org/10.1016/j.tetasy.2006.08.017
Publikováno v:
Tetrahedron: Asymmetry. 16:2631-2647
Three m-hydrobenzoin derived chiral hydrobenzoin mono-tert-butyl ethers were synthesized by a new reaction pathway and tested as chiral auxiliaries in the L-selectride® mediated stereoselective reduction of their corresponding phenyl glyoxylates. As
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c49e3c8a2b561b51c2f985090582384
https://doi.org/10.1016/j.tetasy.2005.06.033
https://doi.org/10.1016/j.tetasy.2005.06.033
Autor:
Obbe P. Zuiderveld, Eric E. J. Haaksma, Kamonchanok Sansuk, Adami M, Joachim Broeker, Gabriella Coruzzi, Rob Leurs, Rogier A. Smits, Elena Guaita, Iwan J. P. de Esch
Publikováno v:
Journal of medicinal chemistry. 51(24)
From a series of small fragments that was designed to probe the histamine H(4) receptor (H(4)R), we previously described quinoxaline-containing fragments that were grown into high affinity H(4)R ligands in a process that was guided by pharmacophore m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7c6e89c5c9a0eb9d819e19f66e22569
https://pubmed.ncbi.nlm.nih.gov/19053770
https://pubmed.ncbi.nlm.nih.gov/19053770
Autor:
Rogier A. Smits, Iwan J. P. de Esch, Obbe P. Zuiderveld, Joachim Broeker, Kamonchanok Sansuk, Elena Guaita, Gabriella Coruzzi, Maristella Adami, Eric Haaksma, Rob Leurs
Publikováno v:
Journal of Medicinal Chemistry; Dec2008, Vol. 51 Issue 24, p7855-7865, 11p
Autor:
Bo Jorgensen, Thomas Bertsch, Hans-Joachim Broeker, Markus Schaefer, Jean-Paul Chapelle, Romy Gadisseur, Martin Cowie, Bert Dikkeschei, Eberhard Gurr, Wiebke Hayen, Gerd Hafner, Yuriko Stiegler, Hans-Robert Schoenherr, Strasser, Ruth H., Britta Weidtmann, Henning Folkerts, Christian Zugck, Kerstin Hofmann, Rainer Zerback
Publikováno v:
Scopus-Elsevier
Imperial College London
Imperial College London
In the second generation of the point-of-care (POC) assay Roche CARDIAC proBNP, the upper limit of the measuring range was extended from 3000 to 9000 ng/L.A thirteen-site multicentre evaluation was carried out to assess the analytical performance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f90433c658041ef776a42f4997807fbe
http://www.scopus.com/inward/record.url?eid=2-s2.0-84863638759&partnerID=MN8TOARS
http://www.scopus.com/inward/record.url?eid=2-s2.0-84863638759&partnerID=MN8TOARS
