Zobrazeno 1 - 10
of 358
pro vyhledávání: '"Joachim, Neumann"'
Publikováno v:
Pharmaceutics, Vol 16, Iss 9, p 1139 (2024)
Semaglutide is a glucagon-like peptide 1 receptor (GLP-1R) agonist. GLP-1R agonists are used to treat type 2 diabetes and obesity. It is currently unknown whether semaglutide can directly increase force of contraction (FOC) in the human heart. We tes
Externí odkaz:
https://doaj.org/article/6a78d4276bc04006af37dc53873a16f3
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Hallucinogenic drugs are used because they have effects on the central nervous system. Their hallucinogenic effects probably occur via stimulation of serotonin receptors, namely, 5-HT2A-serotonin receptors in the brain. However, a close study reveals
Externí odkaz:
https://doaj.org/article/d08f83af76b94f0599aada5f6b5435bd
Publikováno v:
Pharmaceuticals, Vol 16, Iss 5, p 734 (2023)
Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventr
Externí odkaz:
https://doaj.org/article/10460d39d24b4276bc665fbc1cea86c4
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
This review addresses pharmacological, structural and functional relationships among H2-histamine receptors and H1-histamine receptors in the mammalian heart. The role of both receptors in the regulation of force and rhythm, including their electroph
Externí odkaz:
https://doaj.org/article/6df007a70e744e6292446b50f1830f2f
Autor:
Joachim Neumann, Juliane M. Grobe, Jacqueline Weisgut, Hubert G. Schwelberger, Wieslawa Agnieszka Fogel, Margaréta Marušáková, Hartmut Wache, Heike Bähre, Igor B. Buchwalow, Stefan Dhein, Britt Hofmann, Uwe Kirchhefer, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Histamine is metabolized by several enzymes in vitro and in vivo. The relevance of this metabolism in the mammalian heart in vivo is unclear. However, histamine can exert positive inotropic effects (PIE) and positive chronotropic effects (PCE) in hum
Externí odkaz:
https://doaj.org/article/b9e038c7f7ca4a09a4890fa49e6fb7b3
Publikováno v:
American Journal of Educational Research. 11:125-132
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a56b807e22dacc080f3849de74dd6cb
https://doi.org/10.12691/education-11-3-4
https://doi.org/10.12691/education-11-3-4
Autor:
Paula Bollmann, Franziska Werner, Marko Jaron, Tom A. Bruns, Hartmut Wache, Jochen Runte, Peter Boknik, Uwe Kirchhefer, Frank U. Müller, Igor B. Buchwalow, Sven Rothemund, Joachim Neumann, Ulrich Gergs
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2021)
As part of our ongoing studies on the potential pathophysiological role of serine/threonine phosphatases (PP) in the mammalian heart, we have generated mice with cardiac-specific overexpression of PP2Cβ (PP2C-TG) and compared them with littermate wi
Externí odkaz:
https://doaj.org/article/b021743755d641a393a09eb53a4cce6f
Publikováno v:
Frontiers in Psychology, Vol 11 (2020)
Quantifying hearing thresholds via mobile self-assessment audiometric applications has been demonstrated repeatedly with heterogenous results regarding the accuracy. One important limitation of several of these applications has been the lack of appro
Externí odkaz:
https://doaj.org/article/a1be8241251d4f12bacaf76e7de28bfa
Autor:
Somy Yoon, Taewon Kook, Hyun-Ki Min, Duk-Hwa Kwon, Young Kuk Cho, Mira Kim, Sera Shin, Hosouk Joung, Seung Hoon Jeong, Sumin Lee, Gaeun Kang, Yunchul Park, Yong Sook Kim, Youngkeun Ahn, Julie R. McMullen, Ulrich Gergs, Joachim Neumann, Kyung Keun Kim, Jungchul Kim, Kwang-Il Nam, Young-Kook Kim, Hyun Kook, Gwang Hyeon Eom
Publikováno v:
Experimental and Molecular Medicine, Vol 50, Iss 7, Pp 1-14 (2018)
Cardiovascular disease: A brake for heart muscle growth A regulatory mechanism that controls how cardiac muscle responds to stress could inform development of new therapies for preventing heart failure. Physiological stimuli ranging from heavy exerci
Externí odkaz:
https://doaj.org/article/baf03256eb114ec282a4f7cff143152e
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 396:669-682
Levosimendan (up to 10 µM) given alone failed to increase force of contraction in isolated electrically stimulated (1 Hz) left atrial (LA) preparations from wild-type mice. Only in the additional presence of 0.1 µM rolipram, an inhibitor of the act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddeca5ccbc102f8ef93b05da7e90ec10
https://doi.org/10.1007/s00210-022-02348-7
https://doi.org/10.1007/s00210-022-02348-7