Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Joachim, Kloehn"'
Autor:
María Pía Alberione, Víctor González-Ruiz, Olivier von Rohr, Serge Rudaz, Dominique Soldati-Favre, Luis Izquierdo, Joachim Kloehn
Publikováno v:
PLoS Pathogens, Vol 20, Iss 6, p e1011979 (2024)
The cell surface of Toxoplasma gondii is rich in glycoconjugates which hold diverse and vital functions in the lytic cycle of this obligate intracellular parasite. Additionally, the cyst wall of bradyzoites, that shields the persistent form responsib
Externí odkaz:
https://doaj.org/article/fac001c6cfd44a8eace6d286dfd71079
Autor:
Vanessa M. Howieson, Joy Zeng, Joachim Kloehn, Christina Spry, Chiara Marchetti, Matteo Lunghi, Emmanuel Varesio, Andrew Soper, Anthony G. Coyne, Chris Abell, Giel G. van Dooren, Kevin J. Saliba
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 22, Iss , Pp 1-8 (2023)
Toxoplasma gondii is a pervasive apicomplexan parasite that can cause severe disease and death in immunocompromised individuals and the developing foetus. The treatment of toxoplasmosis often leads to serious side effects and novel drugs and drug tar
Externí odkaz:
https://doaj.org/article/00b024bbf99f4341a185721a0ef4505e
Autor:
Emma Pietsch, Abhinay Ramaprasad, Sabrina Bielfeld, Yvonne Wohlfarter, Bohumil Maco, Korbinian Niedermüller, Louisa Wilcke, Joachim Kloehn, Markus A. Keller, Dominique Soldati-Favre, Michael J. Blackman, Tim-Wolf Gilberger, Paul-Christian Burda
Publikováno v:
mBio, Vol 14, Iss 6 (2023)
ABSTRACTPlasmodium parasites rely on a functional electron transport chain (ETC) within their mitochondrion for proliferation, and compounds targeting mitochondrial functions are validated antimalarials. Here, we localize Plasmodium falciparum patati
Externí odkaz:
https://doaj.org/article/f35cc9f369ff4e73b649d2374544ac7b
Autor:
Matteo Lunghi, Joachim Kloehn, Aarti Krishnan, Emmanuel Varesio, Oscar Vadas, Dominique Soldati-Favre
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Coenzyme A (CoA) is an essential metabolite found in all organisms and its synthesis involves five conserved enzymatic steps and uses pantothenate (Pan) as a precursor. Here, Lunghi et al. examine the Pan synthesis pathway in Toxoplasma gondii and fi
Externí odkaz:
https://doaj.org/article/760ba6dad3434446ad5b05a1f7b99b8a
Autor:
Joachim Kloehn, Rebecca D. Oppenheim, Ghizal Siddiqui, Pieter-Jan De Bock, Sunil Kumar Dogga, Yohann Coute, Mohamed-Ali Hakimi, Darren J. Creek, Dominique Soldati-Favre
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-26 (2020)
Abstract Background Acetyl-CoA is a key molecule in all organisms, implicated in several metabolic pathways as well as in transcriptional regulation and post-translational modification. The human pathogen Toxoplasma gondii possesses at least four enz
Externí odkaz:
https://doaj.org/article/0004984a4e99407ead65792007c4abe9
Autor:
Kevin X. Lau, Elizabeth A. Mason, Joshua Kie, David P. De Souza, Joachim Kloehn, Dedreia Tull, Malcolm J. McConville, Andrew Keniry, Tamara Beck, Marnie E. Blewitt, Matthew E. Ritchie, Shalin H. Naik, Daniela Zalcenstein, Othmar Korn, Shian Su, Irene Gallego Romero, Catrina Spruce, Christopher L. Baker, Tracy C. McGarr, Christine A. Wells, Martin F. Pera
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Human pluripotent cells (hPSCs) in standard culture are similar to mouse epiblast cells, but heterogeneity within hPSC cultures complicates comparisons. Here the authors show that a subpopulation of hPSCs enriched for self-renewal capacity have disti
Externí odkaz:
https://doaj.org/article/1f87c566710a45a38bb6a81fc0b27bcc
Autor:
Joachim Kloehn, Berin A. Boughton, Eleanor C. Saunders, Sean O’Callaghan, Katrina J. Binger, Malcolm J. McConville
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
Many microbial pathogens switch between different growth and physiological states in vivo
Externí odkaz:
https://doaj.org/article/d9f0bd30de6d441faea13decd874b072
Autor:
Soner Yildiz, João P Pereira Bonifacio Lopes, Matthieu Bergé, Víctor González-Ruiz, Damian Baud, Joachim Kloehn, Inês Boal-Carvalho, Olivier P Schaeren, Michael Schotsaert, Lucy J Hathaway, Serge Rudaz, Patrick H Viollier, Siegfried Hapfelmeier, Patrice Francois, Mirco Schmolke
Publikováno v:
eLife, Vol 9 (2020)
Under eubiotic conditions commensal microbes are known to provide a competitive barrier against invading bacterial pathogens in the intestinal tract, on the skin or on the vaginal mucosa. Here, we evaluate the role of lung microbiota in Pneumococcus
Externí odkaz:
https://doaj.org/article/448b1fc06cc04fff8970db9ed0e79ac1
Publikováno v:
Metabolites, Vol 11, Iss 8, p 476 (2021)
Apicomplexan parasites are responsible for devastating diseases, including malaria, toxoplasmosis, and cryptosporidiosis. Current treatments are limited by emerging resistance to, as well as the high cost and toxicity of existing drugs. As obligate i
Externí odkaz:
https://doaj.org/article/0b77a06974a44493a2de37203db1df53
Publikováno v:
Current Opinion in Microbiology. 63:250-258
The apicoplast is the relict of a plastid organelle found in several disease-causing apicomplexan parasites such as Plasmodium spp. and Toxoplasma gondii. In these organisms, the organelle has lost its photosynthetic capability but harbours several f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abe8f078b4cbc1d37e95079b2ab97dd0
https://doi.org/10.1016/j.mib.2021.07.016
https://doi.org/10.1016/j.mib.2021.07.016