Zobrazeno 1 - 10
of 127
pro vyhledávání: '"Joachim, Geyer"'
Autor:
Hongtao Liu, Dariusz Zakrzewicz, Kamil Nosol, Rossitza N. Irobalieva, Somnath Mukherjee, Rose Bang-Sørensen, Nora Goldmann, Sebastian Kunz, Lorenzo Rossi, Anthony A. Kossiakoff, Stephan Urban, Dieter Glebe, Joachim Geyer, Kaspar P. Locher
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract Cellular entry of the hepatitis B and D viruses (HBV/HDV) requires binding of the viral surface polypeptide preS1 to the hepatobiliary transporter Na+-taurocholate co-transporting polypeptide (NTCP). This interaction can be blocked by bulevi
Externí odkaz:
https://doaj.org/article/f9ddf8c868954a5d843a6783bfb948e5
Publikováno v:
Frontiers in Veterinary Science, Vol 11 (2024)
Synthesis and secretion of bile acids (BA) is a key physiological function of the liver. In pathological conditions like portosystemic shunt, hepatic insufficiency, hepatitis, or cirrhosis BA metabolism and secretion are disturbed. Quantification of
Externí odkaz:
https://doaj.org/article/a296ade0f1c94693bd6bbb431b0dcb11
Autor:
Emre Karakus, Andreas Schmid, Silke Leiting, Bärbel Fühler, Andreas Schäffler, Thilo Jakob, Joachim Geyer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2022)
In addition to the endocrine and paracrine systems, peripheral tissues such as gonads, skin, and adipose tissue are involved in the intracrine mechanisms responsible for the formation of sex steroids via the transformation of dehydroepiandrosterone a
Externí odkaz:
https://doaj.org/article/9596557c27824cc5a3106399a39a88b5
Autor:
Michael Kirstgen, Kira Alessandra Alicia Theresa Lowjaga, Simon Franz Müller, Nora Goldmann, Felix Lehmann, Sami Alakurtti, Jari Yli-Kauhaluoma, Dieter Glebe, Joachim Geyer
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Current treatment options against hepatitis B and D virus (HBV/HDV) infections have only limited curative effects. Identification of Na+/taurocholate co-transporting polypeptide (NTCP) as the high-affinity hepatic receptor for both viruses i
Externí odkaz:
https://doaj.org/article/b5edf866c0b64b18948a6735dc0b00e5
Autor:
Daniela Nürnberger, Lisa Wagner, Simon F. Müller, Silke Leiting, Regina Leidolf, Jörg Alber, Melanie Hamann, Joachim Geyer
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2022)
The multidrug resistance gene MDR1 (syn. ABCB1) encodes for the multidrug efflux transporter P-glycoprotein (P-gp), which is highly expressed at the blood-brain barrier and protects the brain from potentially neurotoxic compounds, such as ivermectin.
Externí odkaz:
https://doaj.org/article/de1d65f8c79943919d009c7016cf2e90
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The solute carrier family 10 member SLC10A7 is a negative regulator of intracellular calcium signaling (RCAS). In cell culture, SLC10A7 expression is negatively correlated with store-operated calcium entry (SOCE) via the plasma membrane. SLC10A7-defi
Externí odkaz:
https://doaj.org/article/e223be57b4eb46689cd53a41b3998859
Publikováno v:
BMC Veterinary Research, Vol 15, Iss 1, Pp 1-5 (2019)
Abstract Background Although the new isoxazoline drug fluralaner (Bravecto®) is generally well tolerated in dogs, adverse drug reactions involving neurological dysfunction occurred in individual dogs. However, most of these cases are documented inad
Externí odkaz:
https://doaj.org/article/05b1b36d42314a69bff76c7afc2eb954
Autor:
Dorothea Leonhäuser, Jasmin Kranz, Regina Leidolf, Patrick Arndt, Ulrich Schwantes, Joachim Geyer, Joachim O. Grosse
Publikováno v:
BMC Urology, Vol 19, Iss 1, Pp 1-8 (2019)
Abstract Background Porcine urinary bladders are widely used for uro-pharmacological examinations due to their resemblance to the human organ. However, characterisations of the porcine urothelium at the molecular level are scarce up to now. As it has
Externí odkaz:
https://doaj.org/article/52540affa9a043f596d36e8bc81e1238
Publikováno v:
Frontiers in Veterinary Science, Vol 8 (2021)
The multidrug resistance gene MDR1 encodes for an efflux transporter called P-glycoprotein (P-gp). In the canine Mdr1 gene, a nonsense mutation was identified in certain dog breeds causing increased drug sensitivity to various P-gp substrates such as
Externí odkaz:
https://doaj.org/article/c7e28c8a7d6b4ac882ebcba01eb7f828
Autor:
Massimo Palatini, Simon Franz Müller, Kira Alessandra Alicia Theresa Lowjaga, Saskia Noppes, Jörg Alber, Felix Lehmann, Nora Goldmann, Dieter Glebe, Joachim Geyer
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
Homodimerization is essential for plasma membrane sorting of the liver bile acid transporter NTCP and its function as Hepatitis B/D Virus (HBV/HDV) receptor. However, the protein domains involved in NTCP dimerization are unknown. NTCP bears two poten
Externí odkaz:
https://doaj.org/article/6c23159bd421475db423da40c2f18bae