Zobrazeno 1 - 10
of 104
pro vyhledávání: '"JoEllyn M McMillan"'
Autor:
Andrea L Martinez-Skinner, Mariluz A Araínga, Pavan Puligujja, Diana L Palandri, Hannah M Baldridge, Benson J Edagwa, JoEllyn M McMillan, R Lee Mosley, Howard E Gendelman
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0145966 (2015)
Long-acting nanoformulated antiretroviral therapy (nanoART) induces a range of innate immune migratory, phagocytic and secretory cell functions that perpetuate drug depots. While recycling endosomes serve as the macrophage subcellular depots, little
Externí odkaz:
https://doaj.org/article/4edb165520984c83af62b4a2df1b1354
Autor:
Nagsen Gautam, JoEllyn M. McMillan, Devendra Kumar, Aditya N. Bade, Qiaoyu Pan, Tanmay A. Kulkarni, Wenkuan Li, Brady Sillman, Nathan A. Smith, Bhagya L. Dyavar Shetty, Adam Szlachetka, Benson J. Edagwa, Howard E. Gendelman, Yazen Alnouti
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Here, the authors provide a mechanism for an improved version of a nanoformulated myristoylated prodrug of cabotegravir (CAB), named NM2CAB, and its bioavailability, stability and pharmacokinetics in mice and rats performed in independent academic an
Externí odkaz:
https://doaj.org/article/2bfe8aa999a043d6aa5d494a5ae8099d
Autor:
Aditya N. Bade, Benson J Edagwa, Denise A. Cobb, Samuel M. Cohen, JoEllyn M McMillan, Nathan Smith, Nagsen Gautam, Yazen Alnouti, Suyash Deodhar, Bhagya Laxmi Dyavar Shetty, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
Nature Communications
Treatment and prevention of human immunodeficiency virus type one (HIV-1) infection was transformed through widespread use of antiretroviral therapy (ART). However, ART has limitations in requiring life-long daily adherence. Such limitations have led
Publikováno v:
Molecular Neurobiology
Dolutegravir (DTG) is a first-line antiretroviral drug (ARV) used in combination therapy for the treatment of human immunodeficiency virus type-1 (HIV-1) infection. The drug is effective, safe, and well tolerated. Nonetheless, concerns have recently
Publikováno v:
AIDS
OBJECTIVE: Antiretroviral drug (ARV) theranostics facilitates the monitoring of biodistribution and efficacy of therapies designed to target human immunodeficiency virus type-1 (HIV-1) reservoirs. To this end, we have now deployed intrinsic drug chem
Autor:
Suyash Deodhar, Brady Sillman, Aditya N. Bade, Sean N. Avedissian, Anthony T. Podany, JoEllyn M. McMillan, Nagsen Gautam, Brandon Hanson, Bhagya L. Dyavar Shetty, Adam Szlachetka, Morgan Johnston, Michellie Thurman, Daniel J. Munt, Alekha K. Dash, Milica Markovic, Arik Dahan, Yazen Alnouti, Alborz Yazdi, Bhavesh D. Kevadiya, Siddappa N. Byrareddy, Samuel M. Cohen, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications. 13
Ultra-long-acting integrase strand transfer inhibitors were created by screening a library of monomeric and dimeric dolutegravir (DTG) prodrug nanoformulations. This led to an 18-carbon chain modified ester prodrug nanocrystal (coined NM2DTG) with th
Autor:
Milankumar Patel, Mahmudul Hasan, Howard E. Gendelman, Srijanee Das, Santhi Gorantla, Dhruvkumar Soni, Jonathan Herskovitz, St Patrick Reid, Benson J Edagwa, Linda Chang, Channabasavaiah B. Gurumurthy, Maxim D. Oleynikov, Bhavesh D. Kevadiya, Neha Bajwa, Wilson R. Blomberg, Robert Eisenberg, Jatin Machhi, JoEllyn M McMillan, Chamindie Punyadeera, Ahmed M. Senan
Publikováno v:
Nature Materials. 20:593-605
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat, cough, chest and muscle pain, dy
Autor:
Milankumar Patel, Channabasavaiah B. Gurumurthy, Mahmudul Hasan, Santhi Gorantla, Srijanee Das, Linda Chang, Neha Bajwa, Dhruvkumar Soni, Jonathan Herskovitz, St Patrick Reid, Robert Eisenberg, Jatin Machhi, JoEllyn M McMillan, Howard E. Gendelman, Chamindie Punyadeera, Benson J Edagwa, Wilson R. Blomberg, Maxim D. Oleynikov, Bhavesh D. Kevadiya, Ahmed M. Senan
Publikováno v:
Journal of Neuroimmune Pharmacology
Graphical abstract The COVID-19 pandemic has affected more than 38 million people world-wide by person to person transmission of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Therapeutic and preventative strategies for SARS-CoV-2
Autor:
Dhruvkumar Soni, Wenting Zhang, Brendan M. Ottemann, Jatin Machhi, JoEllyn M McMillan, Kristen N. Sikora, R. Lee Mosley, Jered C. Garrison, Insiya Mukadam, Howard E. Gendelman, Bhavesh D. Kevadiya, James R. Hilaire, Mahmudul Hasan, Laura Castellanos, Sarella Anandakumar, Jonathan Herskovitz, Benson J Edagwa, Richard W. Vachet
Publikováno v:
Theranostics
Human immunodeficiency virus theranostics facilitates the development of long acting (LA) antiretroviral drugs (ARVs) by defining drug-particle cell depots. Optimal drug formulations are made possible based on precise particle composition, structure,
Autor:
Nagsen Gautam, Howard E. Gendelman, Melinda Wojtkiewicz, Bhagya Laxmi Dyavar Shetty, Mary G. Banoub, JoEllyn M McMillan, Denise A. Cobb, Yazen Alnouti, Aditya N. Bade, Zhiyi Lin, Benson J Edagwa
Publikováno v:
Mol Pharm
Antiretroviral therapy (ART) has improved the quality of life in patients infected with HIV-1. However, complete viral suppression within anatomical compartments remains unattainable. This is complicated by adverse side effects and poor adherence to