Zobrazeno 1 - 10
of 13
pro vyhledávání: '"JoEllyn, McMillan"'
Autor:
Denise A. Cobb, Nathan Smith, Suyash Deodhar, Aditya N. Bade, Nagsen Gautam, Bhagya Laxmi Dyavar Shetty, JoEllyn McMillan, Yazen Alnouti, Samuel M. Cohen, Howard E. Gendelman, Benson Edagwa
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Antiretroviral therapy (ART) for the treatment of HIV-1 requires life-long daily adherence to supress viral replication, and nucleoside reverse transcriptase inhibitors that are commonly used in ART have not been converted into long-acting agents. He
Externí odkaz:
https://doaj.org/article/e78ef827a6654617b246aed85af2acee
Autor:
Prasanta K. Dash, Fadhel A. Alomar, Jesse L. Cox, JoEllyn McMillan, Bryan T. Hackfort, Edward Makarov, Brenda Morsey, Howard S. Fox, Howard E. Gendelman, Santhi Gorantla, Keshore R. Bidasee
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 8 (2021)
Early-onset heart failure (HF) continues to be a major cause of morbidity and mortality in people living with human immunodeficiency virus type one (HIV-1) infection (PLWH), yet the molecular causes for this remain poorly understood. Herein NOD.Cg-Pr
Externí odkaz:
https://doaj.org/article/4f2a27b9809f46c2b078238674c554a2
Autor:
Prasanta K. Dash, Rafal Kaminski, Ramona Bella, Hang Su, Saumi Mathews, Taha M. Ahooyi, Chen Chen, Pietro Mancuso, Rahsan Sariyer, Pasquale Ferrante, Martina Donadoni, Jake A. Robinson, Brady Sillman, Zhiyi Lin, James R. Hilaire, Mary Banoub, Monalisha Elango, Nagsen Gautam, R. Lee Mosley, Larisa Y. Poluektova, JoEllyn McMillan, Aditya N. Bade, Santhi Gorantla, Ilker K. Sariyer, Tricia H. Burdo, Won-Bin Young, Shohreh Amini, Jennifer Gordon, Jeffrey M. Jacobson, Benson Edagwa, Kamel Khalili, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-20 (2019)
Here, the authors show that sequential treatment with long-acting slow-effective release ART and AAV9- based delivery of CRISPR-Cas9 results in undetectable levels of virus and integrated DNA in a subset of humanized HIV-1 infected mice. This proof-o
Externí odkaz:
https://doaj.org/article/ad4b010214414d8c84777d8ae90f684b
Autor:
Brady Sillman, Aditya N. Bade, Prasanta K. Dash, Biju Bhargavan, Ted Kocher, Saumi Mathews, Hang Su, Georgette D. Kanmogne, Larisa Y. Poluektova, Santhi Gorantla, JoEllyn McMillan, Nagsen Gautam, Yazen Alnouti, Benson Edagwa, Howard E. Gendelman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Current ART for treatment of HIV-1 infection requires a strict daily regimen adherence. Herein, the authors report the manufacture and characterization of a nanoformulated dolutegravir prodrug with improved cell and tissue penetration, a remarkable a
Externí odkaz:
https://doaj.org/article/9fe938444e464eaea1e85845549ff241
Autor:
Fadhel A. Alomar, Abdullah Al-Rubaish, Fahad Al-Muhanna, Amein K. Al-Ali, JoEllyn McMillan, Jaipaul Singh, Keshore R. Bidasee
Publikováno v:
Antioxidants, Vol 9, Iss 7, p 592 (2020)
Accumulation of methylglyoxal (MG) arising from downregulation of its primary degrading enzyme glyoxalase-1 (Glo1) is an underlying cause of diabetic cardiomyopathy (DC). This study investigated if expressing Glo1 in rat hearts shortly after the onse
Externí odkaz:
https://doaj.org/article/ff24becce18d4b92a15e213fb93883a9
Autor:
Chao-Jiang Gu, Alejandra Borjabad, Eran Hadas, Jennifer Kelschenbach, Boe-Hyun Kim, Wei Chao, Ottavio Arancio, Jin Suh, Bruce Polsky, JoEllyn McMillan, Benson Edagwa, Howard E Gendelman, Mary Jane Potash, David J Volsky
Publikováno v:
PLoS Pathogens, Vol 14, Iss 6, p e1007061 (2018)
Suppression of HIV replication by antiretroviral therapy (ART) or host immunity can prevent AIDS but not other HIV-associated conditions including neurocognitive impairment (HIV-NCI). Pathogenesis in HIV-suppressed individuals has been attributed to
Externí odkaz:
https://doaj.org/article/3593da4864114c1e82e78c8b2f270cc6
Autor:
Bhavesh D, Kevadiya, Jatin, Machhi, Jonathan, Herskovitz, Maxim D, Oleynikov, Wilson R, Blomberg, Neha, Bajwa, Dhruvkumar, Soni, Srijanee, Das, Mahmudul, Hasan, Milankumar, Patel, Ahmed M, Senan, Santhi, Gorantla, JoEllyn, McMillan, Benson, Edagwa, Robert, Eisenberg, Channabasavaiah B, Gurumurthy, St Patrick M, Reid, Chamindie, Punyadeera, Linda, Chang, Howard E, Gendelman
Publikováno v:
Nature materials. 20(5)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread to nearly every corner of the globe, causing societal instability. The resultant coronavirus disease 2019 (COVID-19) leads to fever, sore throat, cough, chest and muscle pain, dy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2357272fe5338a51298617f798572463
https://pubmed.ncbi.nlm.nih.gov/33881342
https://pubmed.ncbi.nlm.nih.gov/33881342
Autor:
JoEllyn McMillan, Prasanta K. Dash, Jatin Machhi, Mark Thomas, Benson J Edagwa, Santhi Gorantla, Divya Prakash Gnanadhas, Zhiyi Lin, Harris A. Gelbard, Howard E. Gendelman
Aim: Pharmacologic agents that affect autophagy were tested for their abilities to enhance macrophage nanoformulated antiretroviral drug (ARV) depots and its slow release. Methods: These agents included URMC-099, rapamycin, metformin, desmethylclomip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69aefd12286e619c5d0c6145b75cb0fc
https://europepmc.org/articles/PMC6219451/
https://europepmc.org/articles/PMC6219451/
Publikováno v:
Handbook of clinical neurology. 152
Human immunodeficiency virus (HIV)-associated neurocognitive disorders (HAND) remain a common end-organ manifestation of viral infection. Subclinical and mild symptoms lead to neurocognitive and behavioral abnormalities. These are associated, in part
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2f63e5237a7440862285b43bffd51f0b
https://pubmed.ncbi.nlm.nih.gov/29604978
https://pubmed.ncbi.nlm.nih.gov/29604978
Autor:
Pawel Cibrowski, Chengju Tian, JoEllyn McMillan, Howard E. Gendelman, Keshore R. Bidasee, Chun Hong Shao
Publikováno v:
The FASEB Journal. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e316804cec4e5c8f7e5f4da248a9e734
https://doi.org/10.1096/fasebj.27.1_supplement.913.54
https://doi.org/10.1096/fasebj.27.1_supplement.913.54