Zobrazeno 1 - 10
of 366
pro vyhledávání: '"JoAnne Stubbe"'
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Publikováno v:
eLife, Vol 11 (2022)
Antibiotic-resistant Neisseria gonorrhoeae (Ng) are an emerging public health threat due to increasing numbers of multidrug resistant (MDR) organisms. We identified two novel orally active inhibitors, PTC-847 and PTC-672, that exhibit a narrow spectr
Externí odkaz:
https://doaj.org/article/e2f24e41f41645fe97c9ca6615d7120b
Autor:
William C. Thomas, F. Phil Brooks, Audrey A. Burnim, John-Paul Bacik, JoAnne Stubbe, Jason T. Kaelber, James Z. Chen, Nozomi Ando
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Ribonucleotide reductase (RNR) catalyzes the conversion of ribonucleotides to deoxyribonucleotides, which is an essential step in DNA synthesis. Here the authors use small-angle X-ray scattering, X-ray crystallography, and cryo-electron microscopy to
Externí odkaz:
https://doaj.org/article/6430e8e15b544ccd941a8a5b5dbc7669
Autor:
Edward J Brignole, Kuang-Lei Tsai, Johnathan Chittuluru, Haoran Li, Yimon Aye, Pawel A Penczek, JoAnne Stubbe, Catherine L Drennan, Francisco Asturias
Publikováno v:
eLife, Vol 7 (2018)
Ribonucleotide reductases (RNRs) convert ribonucleotides into deoxyribonucleotides, a reaction essential for DNA replication and repair. Human RNR requires two subunits for activity, the α subunit contains the active site, and the β subunit houses
Externí odkaz:
https://doaj.org/article/5584fcf5814d4af1aea70c4e3427daba
Publikováno v:
Journal of the American Chemical Society. 145:5145-5154
Publikováno v:
Chemical Science.
Peak and half-peak potentials poorly approximate standard reduction potentials (E0), especially for compounds that dissociate upon reduction. We determine E0 of disulfides and show cysteine disulfide radical anion to be a powerful biological reductan
Publikováno v:
Journal of the American Chemical Society
The Journal of the American Chemical Society
The Journal of the American Chemical Society
The role of water in biological proton-coupled electron transfer (PCET) is emerging as a key for understanding mechanistic details at atomic resolution. Here we demonstrate 17O high-frequency electron–nuclear double resonance (ENDOR) in conjunction
Autor:
Andreas Meyer, Annemarie Kehl, Chang Cui, Fehmke A. K. Reichardt, Fabian Hecker, Lisa-Marie Funk, Manas K. Ghosh, Kuan-Ting Pan, Henning Urlaub, Kai Tittmann, JoAnne Stubbe, Marina Bennati
Publikováno v:
Journal of the American Chemical Society
Ribonucleotide reductases (RNRs) catalyze the reduction of ribonucleotides to deoxyribonucleotides, thereby playing a key role in DNA replication and repair. Escherichia coli class Ia RNR is an α2β2 enzyme complex that uses a reversible multistep r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3ae7da97f471aecad15672c5fd97a2f
https://hdl.handle.net/21.11116/0000-000A-E2CB-221.11116/0000-000A-E2CD-0
https://hdl.handle.net/21.11116/0000-000A-E2CB-221.11116/0000-000A-E2CD-0
Autor:
Jana Narasimhan, Suzanne Letinski, Stephen P Jung, Aleksey Gerasyuto, Jiashi Wang, Michael Arnold, Guangming Chen, Jean Hedrick, Melissa Dumble, Kanchana Ravichandran, Talya Levitz, Chang Cui, Catherine L Drennan, JoAnne Stubbe, Gary Karp, Arthur Branstrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::242c3ecb2516113bcfac9a95f12d9626
https://doi.org/10.7554/elife.67447.sa2
https://doi.org/10.7554/elife.67447.sa2
Publikováno v:
Science
Caught in the act Proton-coupled electron transfer (PCET) is an important process for moving electrons through proteins and requires precise positioning of suitable proton and electron carriers. Kang et al. determined a cryo–electron microscopy str