Zobrazeno 1 - 10
of 255
pro vyhledávání: '"JoAnne S. Richards"'
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Tomoko Kawai et al. investigate DNA methylation patterns during granulosa cell differentiation and proliferation. Their results suggest that sequential epigenetic events are essential for progressive changes in granulosa cell differentiation.
Externí odkaz:
https://doaj.org/article/fef3db0fb6f540289a39509f239725bc
Autor:
Achuth Padmanabhan, Nicholes Candelaria, Kwong-Kwok Wong, Bryan C. Nikolai, David M. Lonard, Bert W. O’Malley, JoAnne S. Richards
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-13 (2018)
Gain-of-function mutants of p53 are important for cancer development and strategies to target specifically these isoforms are being investigated. Here the authors report that USP15 is a deubiquitinase specifically regulating p53-R175H levels that can
Externí odkaz:
https://doaj.org/article/ed69d97e703b4b0db8b927bb34b0aba6
Autor:
Lisa K. Mullany, Kwong-Kwok Wong, David C. Marciano, Panagiotis Katsonis, Erin R. King-Crane, Yi Athena Ren, Olivier Lichtarge, JoAnne S. Richards
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 10, Pp 789-803 (2015)
Evolutionary Action analyses of The Cancer Gene Atlas data sets show that many specific p53 missense and gain-of-function mutations are selectively overrepresented and functional in high-grade serous ovarian cancer (HGSC). As homozygous alleles, p53
Externí odkaz:
https://doaj.org/article/2044a98092454f85b39ccb8741147215
Real-time PCR primer set sequences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c30ef6763f3cdb2c5a5881b3adba80d
https://doi.org/10.1158/0008-5472.22411352.v1
https://doi.org/10.1158/0008-5472.22411352.v1
Description of additional methods and procedures used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aeb0fada335f1cbfe47b2a8749df7f12
https://doi.org/10.1158/0008-5472.22411358
https://doi.org/10.1158/0008-5472.22411358
Mutations in the tumor protein p53 (TP53) are the most frequently occurring genetic events in high-grade ovarian cancers, especially the prevalence of the Trp53R172H-mutant allele. In this study, we investigated the impact of the Trp53R172H-mutant al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b6e6d576b4cd40edd477a870e3992e1
https://doi.org/10.1158/0008-5472.c.6508202.v1
https://doi.org/10.1158/0008-5472.c.6508202.v1
Sequencing results of laser capture microdissected human mucinous tumor cells (S1); Representative images of immunofluorescent staining for ESR1 and PGR in cultured tumor OSE cells of different genetic background (S2).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0435616eae77a202d562ead8fdb2aa8
https://doi.org/10.1158/0008-5472.22411361.v1
https://doi.org/10.1158/0008-5472.22411361.v1
Autor:
JoAnne S. Richards, Makoto M. Taketo, Jean Sirois, Richard R. Behringer, Soazik P. Jamin, Jinsong Liu, Minnie Hsieh, Marilene Paquet, Derek Boerboom
Supplementary Table 1 from Misregulated Wnt/β-Catenin Signaling Leads to Ovarian Granulosa Cell Tumor Development
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f970e22db718494592553a7f737b207
https://doi.org/10.1158/0008-5472.22364507.v1
https://doi.org/10.1158/0008-5472.22364507.v1
Autor:
JoAnne S. Richards, Francesco J. DeMayo, John P. Lydon, Jinrong Wang, Marilene Paquet, Zhilin Liu, Heng-Yu Fan
The small G-protein KRAS is crucial for mediating gonadotropin-induced events associated with ovulation. However, constitutive expression of KrasG12D in granulosa cells disrupted normal follicle development leading to the persistence of abnormal foll
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6cc36b8c6c1832c12020cdf452488f5f
https://doi.org/10.1158/0008-5472.c.6499091.v1
https://doi.org/10.1158/0008-5472.c.6499091.v1
Autor:
JoAnne S. Richards, Makoto M. Taketo, Jean Sirois, Richard R. Behringer, Soazik P. Jamin, Jinsong Liu, Minnie Hsieh, Marilene Paquet, Derek Boerboom
Misregulation of the Wnt/β-catenin signaling pathway is a hallmark of several forms of cancer. Components of the Wnt/β-catenin pathway are expressed in ovarian granulosa cells; nevertheless, its potential involvement in granulosa cell tumorigenesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48ef425657cf6d6924454c07cf31dd66
https://doi.org/10.1158/0008-5472.c.6494219
https://doi.org/10.1158/0008-5472.c.6494219