Výsledky vyhledávání - "JoAnne Montalbano"

Loss of the Par3 Polarity Protein Promotes Breast Tumorigenesis and Metastasis

Autor: Luke McCaffrey, JoAnne Montalbano, Constantina Mihai, Ian G. Macara

Publikováno v: Cancer Cell. 22(5):601-614

SummaryLoss of epithelial organization is a hallmark of carcinomas, but whether polarity regulates tumor growth and metastasis is poorly understood. To address this issue, we depleted the Par3 polarity gene by RNAi in combination with oncogenic Notch

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Identification and Characterization of RBEL1 Subfamily of GTPases in the Ras Superfamily Involved in Cell Growth Regulation

Autor: JoAnne Montalbano, Ying Huang, M. Saeed Sheikh, Ki Lui

Publikováno v: Journal of Biological Chemistry. 284:18129-18142

Recently, we reported the identification of a novel gene named RBEL1 (Rab-like protein 1) and characterized its two encoded isoforms, RBEL1A and RBEL1B, that function as novel GTPases of Ras superfamily. Here we report the identification of two addit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335f84e0cb168b3f79a81611c982f950
https://doi.org/10.1074/jbc.m109.009597

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Oncogenic Ras-mediated downregulation of Gadd153/CHOP is required for Ras-induced cellular transformation

Autor: Rong Rong, Jennifer Zhang, M. Saeed Sheikh, Weixin Jin, JoAnne Montalbano, Ying Huang, Maria Garling

Publikováno v: Oncogene. 24:4867-4872

Oncogenic Ras proteins transform cells via multiple downstream signaling cascades that are important for cell proliferation and survival. Gadd153, also known as CHOP, is a growth inhibitory and proapoptotic protein and its expression is upregulated b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdc5eb42d63478a18cf26c283247a901
https://doi.org/10.1038/sj.onc.1208660

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Human T-Cell Leukemia Virus Type 1 Tax Oncoprotein Suppression of Multilineage Hematopoiesis of CD34+Cells In Vitro

Autor: JoAnne Montalbano, Stephen Wrzesinski, Adam Tripp, Michelle Sieburg, Gerold Feuer, Yingxian Liu

Publikováno v: Journal of Virology. 77:12152-12164

Human T-cell leukemia virus type 1 (HTLV-1) and HTLV-2 are highly related viruses that differ in disease manifestation. HTLV-1 is the etiologic agent of adult T-cell leukemia and lymphoma, an aggressive clonal malignancy of human CD4-bearing T lympho

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https://doi.org/10.1128/jvi.77.22.12152-12164.2003

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Negative regulation of p53 by Ras superfamily protein RBEL1A

Autor: M. Saeed Sheikh, Jingxue Shi, Hong Sun, JoAnne Montalbano, Ki Lui, Jie An, Qin He, Chad A. Corcoran, Ying Huang

Publikováno v: Journal of cell science. 126(Pt 11)

We had previously reported that RBEL1A, a novel Ras-like GTPase, was overexpressed in multiple human malignancies and that its depletion suppressed cell growth. However, the underlying molecular mechanism remained to be elucidated. Here we report tha

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https://pubmed.ncbi.nlm.nih.gov/23572512

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DOC45, a novel DNA damage-regulated nucleocytoplasmic ATPase that is overexpressed in multiple human malignancies

Autor: Hong Sun, M. Saeed Sheikh, Xiuquan Luo, JoAnne Montalbano, Ying Huang, Weixin Jin, Jingxue Shi

Publikováno v: Molecular cancer research : MCR. 8(1)

In this article, we report the characterization of a novel DNA damage–regulated gene, named DNA damage–regulated overexpressed in cancer 45 (DOC45). Our results indicate that DNA damage–inducing agents, including doxorubicin (adriamycin), etopo

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https://pubmed.ncbi.nlm.nih.gov/20053727

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Identification and characterization of two novel isoforms of Pirh2 ubiquitin ligase that negatively regulate p53 independent of RING finger domains

Autor: Chad A. Corcoran, Qin He, Ying Huang, M. Saeed Sheikh, Hong Sun, JoAnne Montalbano

Publikováno v: The Journal of biological chemistry. 284(33)

Pirh2 is a newly identified E3 ubiquitin ligase known to inhibit tumor suppressor p53 function via ubiquitination and proteasomal degradation. We have identified two novel Pirh2 splice variants that encode different Pirh2 isoforms and named these Pir

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https://pubmed.ncbi.nlm.nih.gov/19483087

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RBEL1 is a novel gene that encodes a nucleocytoplasmic Ras superfamily GTP-binding protein and is overexpressed in breast cancer

Autor: Weixin Jin, JoAnne Montalbano, M. Saeed Sheikh, Ying Huang

Publikováno v: The Journal of biological chemistry. 282(52)

Rab family proteins are generally known as regulators of protein transport and trafficking. A number of Rab proteins have been implicated in cancer development and/or progression. Here we report the identification of a novel Rab-like protein, which w

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https://pubmed.ncbi.nlm.nih.gov/17962191

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