Obesity differentially effects the somatosensory cortex and striatum of TgF344-AD rats

Autor: Minhal Ahmed, Aaron Y. Lai, Mary E. Hill, Jessica A. Ribeiro, Ashley Amiraslani, JoAnne McLaurin

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)

Abstract Lifestyle choices leading to obesity, hypertension and diabetes in mid-life contribute directly to the risk of late-life Alzheimer’s disease (AD). However, in late-life or in late-stage AD conditions, obesity reduces the risk of AD and dis

Externí odkaz: https://doaj.org/article/ac82703224a7468d9a9f3ecb9991931d

Using co-creation focus groups to customise a remote multidomain programme designed to increase dementia literacy

Autor: Aravind Ganesh, Teresa Liu-Ambrose, Natalie Phillips, Kenneth Rockwood, Edeltraut Kröger, Nathan Herrmann, Guangyong Zou, Paul Mick, Serge Gauthier, Walter Wittich, Marie-Céline Lorenzini, Danielle Laurin, Gillian Einstein, Jennifer Bethell, Eric Smith, Karen Messer, Caroline Duchaine, Andrew Hamilton, Heather Keller, Barry Greenberg, Lesley Miller, Susan Marzolini, Robin Hsiung, Jennifer Campos, Jennifer Walker, Catherine Hughes, Nicole Gervais, Andrew Centen, Louis Bherer, Brigitte Gilbert, Amanda Wagner, Katherine Siminovitch, Laura Middleton, Carol Thomas, Andrew Lim, Nicole Anderson, Quincy Almeida, Ron Postuma, Nadia Gosselin, Howard Feldman, Alan Evans, Howard Chertkow, Nellie Kamkar, Manuel Montero-Odasso, Mark Speechley, Bill McIlroy, Richard Camicioli, Roger Marple, Raed Joundi, Chris McGibbon, Linda Yetman, Bryn Robinson, Sylvie Belleville, Haakon Nygaard, Danielle Alcock, Sarah Banks, Paul Brewster, Senny Chan, Marc Cuesta, Samir Das, Carol Evans, Guylaine Ferland, Scott Hofer, Inbal Itzhak, Diane Jacobs, Jody-Lynn Lupo, Zia Mohades, Carolyn Revta, Julie Robillard, Penny Slack, Kayla Regan, Gabrielle Aubin, Asma Fadhlaoui, Nicole D Anderson, Nouha Ben Gaied, Joyla Furlano, Pamela Jarrett, Michael Borrie, January Durant, Tatiana Herold, Yanina Sarquis-Adamson, Penelope Slack, Amal Trigui, Shahnaz Winer, Fatim Ajwani, Anas Alrohimi, Gabrielle Aubin Geneviève Arsenault-Lapierre, Maude Bouchard, Mark Boulos, Jacqueline Burt, Asif Javed Butt, Julie Carrier, Alison Chasteen, Rachel A. Crockett, Danielle D’Amico, Véronique Daneault, Thanh Dang-Vu, Alex Desautels, Caroline Desrosiers, Shirley Dumassais, Emily Dwosh, Margaret Fahnestok, Ryan Stanley Falck, Alexandra Fiocco, Christine Gagnon, Jean-François Gagnon, Liisa Galea, Catherine-Alexandra Grégoire, Stephanie Huang, Inbal Itzak, Elizaveta Klekovkina, Kim Lasnier-Le Quang, Dominique Lorrain, Kaljani Mahalingam, Sarantia Samantha Maltezos, Brooklyn Mankasingh, Samira Mehrabi, Tatiyana Mollayeva, Annabelle Moore, Aline Moussard, Reanne Mundadan, Kelly Murphy, Leigh-Anne M. Noltie, JB Orange, Emilie Parolin, Kathy Pichora-Fuller, Lori Piquette, Jason Plaks, Avery Pratt, Maria Natasha Rajah, Helli Raptis, Anne Julien-Rocheleau, Marie Y. Savundranayagam, Kylie Sullivan, Munira Sultana, Fatima Tangkhpanya, Talar Tcherkezian, Anne-Julie Tessier, Lynn Valeyry Verty, Stephanie Yamin, Anthonio Zadra, Rolando Acosta, Camille Beaudoin, Charlie Henri-Bellamare, Jessica Callegaro, Milad Heshmati, Pierre Pac Soo, Krista Lanctot, Joanne McLaurin, Paul Territo, Donald Weaver, Cheryl Wellington, Rida Abou-Haidar, Sarah Best, Korbin Blue, Isabella Celotto, Lauren Cole, Roger Dixon, Hiroko Dodge, Nada Elhayek, Thalia Field, Jason Haassenstab, Josée Hachee, Lisa Madlesnky, Lauren Moniz, Hanin Omar, Chris Pauley, Jenna Sands Ève Samson, Andrew Sexton, Sheetal Shajan, Sachie Sharma, Mariam Sidrak, Julia Truemner, François Boutin, Yves Boutot, Lise Daigle, Nita Goldband, Elaine Harris, Janet Finkelstein, Kateri Marchand, Lloyd Schneider

Publikováno v: BMJ Open, Vol 13, Iss 9 (2023)

Objectives To adapt the content and functionalities of Brain Health PRO, a web-based multidomain program designed to increase dementia literacy, to the context and needs of users, providers and community organisations across Québec, Canada.Design Fi

Externí odkaz: https://doaj.org/article/a786b6250ffb4973bb249507283a34ac

Ascl1 phospho-site mutations enhance neuronal conversion of adult cortical astrocytes in vivo

Autor: Hussein Ghazale, EunJee Park, Lakshmy Vasan, James Mester, Fermisk Saleh, Andrea Trevisiol, Dawn Zinyk, Vorapin Chinchalongporn, Mingzhe Liu, Taylor Fleming, Oleksandr Prokopchuk, Natalia Klenin, Deborah Kurrasch, Maryam Faiz, Bojana Stefanovic, JoAnne McLaurin, Carol Schuurmans

Publikováno v: Frontiers in Neuroscience, Vol 16 (2022)

Direct neuronal reprogramming, the process whereby a terminally differentiated cell is converted into an induced neuron without traversing a pluripotent state, has tremendous therapeutic potential for a host of neurodegenerative diseases. While there

Externí odkaz: https://doaj.org/article/0eb03c295a474e0c9abfd4326919866b

The effects of voluntary running on cerebrovascular morphology and spatial short-term memory in a mouse model of amyloidosis

Autor: Ewelina Maliszewska-Cyna, Laura M. Vecchio, Lynsie A.M. Thomason, Jonathan J. Oore, Joe Steinman, Illsung Lewis Joo, Adrienne Dorr, JoAnne McLaurin, John G. Sled, Bojana Stefanovic, Isabelle Aubert

Publikováno v: NeuroImage, Vol 222, Iss , Pp 117269- (2020)

Physical activity has been correlated with a reduced risk of cognitive decline, including that associated with vascular dementia, mild cognitive impairment (MCI) and Alzheimer's disease (AD); recent literature suggests this may in part result from be

Externí odkaz: https://doaj.org/article/fb853e4ad16b4a81b84c17e1b1c69a26

Clearance of interstitial fluid (ISF) and CSF (CLIC) group—part of Vascular Professional Interest Area (PIA)

Autor: Roxana O. Carare, Roxana Aldea, Nivedita Agarwal, Brian J. Bacskai, Ingo Bechman, Delphine Boche, Guojun Bu, Diederik Bulters, Alt Clemens, Scott E. Counts, Mony deLeon, Per K. Eide, Silvia Fossati, Steven M. Greenberg, Edith Hamel, Cheryl A. Hawkes, Maya Koronyo‐Hamaoui, Atticus H. Hainsworth, David Holtzman, Masafumi Ihara, Angela Jefferson, Raj N. Kalaria, Christopher M. Kipps, Katja M. Kanninen, Ville Leinonen, JoAnne McLaurin, Scott Miners, Tarja Malm, James A. R. Nicoll, Fabrizio Piazza, Gesine Paul, Steven M. Rich, Satoshi Saito, Andy Shih, Henrieta Scholtzova, Heather Snyder, Peter Snyder, Finnbogi Rutur Thormodsson, Susanne J. vanVeluw, Roy O. Weller, David J. Werring, Donna Wilcock, Mark R. Wilson, Berislav V. Zlokovic, Ajay Verma

Publikováno v: Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020)

Abstract Two of the key functions of arteries in the brain are (1) the well‐recognized supply of blood via the vascular lumen and (2) the emerging role for the arterial walls as routes for the elimination of interstitial fluid (ISF) and soluble met

Externí odkaz: https://doaj.org/article/ceb1d3c3aead4990b98e008e0a4165b1