Zobrazeno 1 - 6
of 6
pro vyhledávání: '"JoAnne L. Greene"'
Autor:
William E. Brady, Robert J. Peach, Jürgen Bajorath, Jeffrey A. Ledbetter, JoAnne L. Greene, Peter S. Linsley
Publikováno v:
Immunity. 1:793-801
B7-0 or B7-2 (CD86) is a T cell costimulatory molecule that binds the same receptors (CD28 and CTLA-4) as B7-1 (CD80), but shares with it only approximately 25% sequence identity and is expressed earlier during an immune response. Here we show that h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddba6be93efd85bc3f728e58d5aab093
https://doi.org/10.1016/s1074-7613(94)80021-9
https://doi.org/10.1016/s1074-7613(94)80021-9
Autor:
Naemura Joseph R, William E. Brady, Peter S. Linsley, Gina Leytze, R. Peach, JoAnne L. Greene, Jürgen Bajorath
Publikováno v:
The Journal of Experimental Medicine
T cell surface receptors CD28 and CTLA-4 are homologous members of the immunoglobulin superfamily (IgSF), each comprising a single V-like extracellular domain. CD28 and CTLA-4 bind to the B7-1 and B7-2 counter-receptors on antigen presenting cells (A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be24cd39e5980519e27f984df11483c2
http://europepmc.org/articles/PMC2191786
http://europepmc.org/articles/PMC2191786
Autor:
Peter S. Linsley, JoAnne L. Greene, Jeff Bradshaw, Jeffrey A. Ledbetter, Patrick Tan, Claudio Anasetti, Nitin K. Damle
Publikováno v:
The Journal of Experimental Medicine
T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28, triggering increased interleukin 2 (IL-2) production and subsequent T ce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::108bbc2c3647d418c902c019d3eb1670
https://doi.org/10.1084/jem.176.6.1595
https://doi.org/10.1084/jem.176.6.1595
Autor:
John Emswiler, JoAnne L. Greene, Wesley L. Cosand, Jürgen Bajorath, Gina Leytze, Peter S. Linsley, Robert J. Peach
Publikováno v:
The Journal of biological chemistry. 271(43)
T lymphocyte receptors CD28 and CTLA-4 bind costimulatory molecules CD80 (B7-1) and CD86 (B7-2) on antigen-presenting cells and regulate T cell activation. While distinct functional roles have been ascribed to each of these molecules, little is known
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::289caf98ccab911c99c14e4793026d94
https://pubmed.ncbi.nlm.nih.gov/8900156
https://pubmed.ncbi.nlm.nih.gov/8900156
Autor:
Robert J. Peach, JoAnne L. Greene, Kelly L. Bennett, Jeff Bradshaw, Peter S. Linsley, Robert S. Mittler
Publikováno v:
Immunity. 4(6)
T lymphocyte receptor CTLA-4 binds costimulatory molecules CD80 (B7-1) and CD86 (B7-2) with high avidity and negatively regulates T cell activation. CTLA-4 functions at the cell surface, yet is primarily localized in intracellular vesicles. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27c3f4d6256c9e4e9a8e5835f03a8968
https://pubmed.ncbi.nlm.nih.gov/8673700
https://pubmed.ncbi.nlm.nih.gov/8673700
Autor:
Jürgen Bajorath, Alejandro Aruffo, Gina Leytze, Robert J. Peach, JoAnne L. Greene, Naemura Joseph R, Peter S. Linsley
Publikováno v:
The Journal of biological chemistry. 270(36)
The B7-related molecules CD80 and CD86 are expressed on antigen-presenting cells, bind the homologous T cell receptors CD28 and CTLA-4, and trigger costimulatory signals important for optimal T cell activation. All four molecules are immunoglobulin s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb7e580e8ea52f8deac74c1f2ec6499
https://pubmed.ncbi.nlm.nih.gov/7545666
https://pubmed.ncbi.nlm.nih.gov/7545666