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pro vyhledávání: '"JoAnn Tuan"'
Publikováno v:
Current Biology. 12:2142-2146
Control of ribosome biogenesis is a potential mechanism for the regulation of cell size during growth [1, 2], and a key step in regulating ribosome production is ribosomal RNA synthesis by RNA polymerase I (Pol I) [3, 4]. In humans, Pol I transcripti
Autor:
JoAnn Tuan, Annick Itie, Michael Debbas, Athena W. Lin, Sushil K. Thukral, Andrew Wakeham, Tak W. Mak, Samuel Benchimol, Ying Lu, Scott W. Lowe, Seiji Kondo, Gary Elliott, Weili Ma, Ildiko Sarosi, Chris Saris
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 100(9)
The tumor suppressor p53 is regulated in part by binding to cellular proteins. We used p53 as bait in the yeast two-hybrid system and isolated homeodomain-interacting protein kinase 1 (HIPK1) as a p53-binding protein. Deletion analysis showed that am