Zobrazeno 1 - 10
of 70
pro vyhledávání: '"JoAnn Trial"'
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107283- (2023)
Summary: The cardiac fibroblast interacts with an extracellular matrix (ECM), enabling myofibroblast maturation via a process called mechanosensing. Although in the aging male heart, ECM is stiffer than in the young mouse, myofibroblast development i
Externí odkaz:
https://doaj.org/article/c8cfa963abd647768375a7e05f7bdf34
Autor:
Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, Anilkumar K. Reddy, Anna Malovannaya, Antrix Jain, Mark L. Entman, George E. Taffet, Katarzyna A. Cieslik
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 323(2)
The incidence of diastolic dysfunction increases with age in both humans and mice. This is characterized by increased passive stiffness and slower relaxation of the left ventricle. The stiffness arises at least partially from progressively increased
Autor:
Rodrigo Diaz Lankenau, George E. Taffet, JoAnn Trial, Katarzyna A. Cieslik, Mark L. Entman, Jorge Enrique Tovar Perez, Aude Angelini
Publikováno v:
GeroScience
Cardiac diastolic dysfunction in aging arises from increased ventricular stiffness caused by inflammation and interstitial fibrosis. The diastolic dysfunction contributes to heart failure with preserved ejection fraction (HFpEF), which in the aging p
Autor:
Mark L. Entman, Katarzyna A. Cieslik, Aude Angelini, Jesus Ortiz-Urbina, JoAnn Trial, George E. Taffet
Publikováno v:
Circulation Research. 129
Heart failure is a major cause of mortality in the elderly. Features of cardiac aging include diastolic dysfunction and interstitial fibrosis with sex-specific differences. We treated old male and female mice (21 months-old) 3 times a week for 3 mont
Publikováno v:
Circulation Research. 127
In the aging heart, fibroblasts have a reduced ability to mature into myofibroblasts (expressing contractile actin a-SMA), which is necessary for scar contraction in wound healing. The mechanosensing pathway bridges the extracellular matrix (ECM) wit
Publikováno v:
Journal of Molecular and Cellular Cardiology. 111:81-85
In 2030, elderly people will represent 20% of the United States population. Even now, chronic cardiac diseases, especially heart failure with preserved systolic function (HFpEF), are the most expensive DRGs for Medicare. Progressive interstitial fibr
Publikováno v:
Ageing Res Rev
The myofibroblast is a specialized fibroblast that expresses α-smooth muscle actin (α-SMA) and participates in wound contraction and fibrosis. The fibroblast to myofibroblast transition depends on chemical and mechanical signals. A fibroblast sense
Publikováno v:
Immunity, Inflammation and Disease
Introduction We studied monocyte transendothelial migration and subsequent polarization into M1/M2 macrophages in response to C‐reactive protein (CRP) with two disease‐related ligands: (1) phosphocholine (PC) and (2) multilamellar liposomes conta
Autor:
Katarzyna A. Cieslik, JoAnn Trial
Publikováno v:
American journal of physiology. Heart and circulatory physiology. 315(4)
The cardiac fibroblast plays a central role in tissue homeostasis and in repair after injury. With aging, dysregulated cardiac fibroblasts have a reduced capacity to activate a canonical transforming growth factor-β-Smad pathway and differentiate po
Publikováno v:
Journal of molecular and cellular cardiology. 111
In 2030, elderly people will represent 20% of the United States population. Even now, chronic cardiac diseases, especially heart failure with preserved systolic function (HFpEF), are the most expensive DRGs for Medicare. Progressive interstitial fibr