Zobrazeno 1 - 10
of 156
pro vyhledávání: '"JoAnn Trejo"'
Autor:
Cierra A. Birch, Helen Wedegaertner, Lennis B. Orduña-Castillo, Monica L. Gonzalez Ramirez, Huaping Qin, JoAnn Trejo
Publikováno v:
Frontiers in Molecular Biosciences, Vol 10 (2023)
Introduction: Dysfunction of the endothelium impairs its’ protective role and promotes inflammation and progression of vascular diseases. Activated Protein C (APC) elicits endothelial cytoprotective responses including barrier stabilization, anti-i
Externí odkaz:
https://doaj.org/article/d9be02a8021e49b38514beaef6fa1af0
Autor:
Xin Zhou, Yanghao Zhong, Olivia Molinar-Inglis, Maya T. Kunkel, Mingyuan Chen, Tengqian Sun, Jiao Zhang, John Y.-J. Shyy, JoAnn Trejo, Alexandra C. Newton, Jin Zhang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
The role of mTORC1 at the lysosome is well established, but mTORC1 is known to be active in other cellular locations. Here, the authors develop Akt-STOPS to inhibit Akt specifically in the nucleus and identify a new regulatory mode for mTORC1 distinc
Externí odkaz:
https://doaj.org/article/328e1750a1694424bd2ac2b272c85bfe
Autor:
JoAnn Trejo, Deborah Wingard, Virginia Hazen, Alexandra Bortnick, Karen Van Hoesen, Angela Byars-Winston, Christine Pfund, Vivian Reznik
Publikováno v:
Journal of Clinical and Translational Science, Vol 6 (2022)
Abstract Introduction: Mentorship is critical for faculty success, satisfaction, and engagement. However, many faculty, particularly underrepresented racial/ethnic (UR) faculty, lack access to high-quality mentoring. In an effort to improve mentorin
Externí odkaz:
https://doaj.org/article/9070e811b3a542cd9baa119aa6c04a82
Autor:
Jeremiah Keyes, Ambhighainath Ganesan, Olivia Molinar-Inglis, Archer Hamidzadeh, Jinfan Zhang, Megan Ling, JoAnn Trejo, Andre Levchenko, Jin Zhang
Publikováno v:
eLife, Vol 9 (2020)
A variety of different signals induce specific responses through a common, extracellular-signal regulated kinase (ERK)-dependent cascade. It has been suggested that signaling specificity can be achieved through precise temporal regulation of ERK acti
Externí odkaz:
https://doaj.org/article/3593a6cf0cf5477998236d4b727a4411
Autor:
Neil J. Grimsey, Rachan Narala, Cara C. Rada, Sohum Mehta, Bryan S. Stephens, Irina Kufareva, John Lapek, David J. Gonzalez, Tracy M. Handel, Jin Zhang, JoAnn Trejo
Publikováno v:
Cell Reports, Vol 24, Iss 12, Pp 3312-3323.e5 (2018)
Summary: Ubiquitination is essential for protein degradation and signaling and pivotal to many physiological processes. Ubiquitination of a subset of G-protein-coupled receptors (GPCRs) by the E3 ligase NEDD4-2 is required for p38 activation, but how
Externí odkaz:
https://doaj.org/article/82640e8206af4d0dadef32fb621a95fe
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0157587 (2016)
Endocytic sorting and lysosomal degradation are integral to the regulation of G protein-coupled receptor (GPCR) function. Upon ligand binding, classical GPCRs are activated, internalized and recycled or sorted to lysosomes for degradation, a process
Externí odkaz:
https://doaj.org/article/b1d689a9649340de89884321b7d1758e
Publikováno v:
International Journal of Molecular Sciences, Vol 19, Iss 7, p 1886 (2018)
G protein-coupled receptors (GPCRs) are a large diverse family of cell surface signaling receptors implicated in various types of cancers. Several studies indicate that GPCRs control many aspects of cancer progression including tumor growth, invasion
Externí odkaz:
https://doaj.org/article/5649161fcb6449559a6ee0e95c51abeb
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0128431 (2015)
BACKGROUND:Streptococcus agalactiae (Group B Streptococcus, GBS) is the leading cause of life-threatening meningitis in human newborns in industrialized countries. Meningitis results from neonatal infection that occurs when GBS leaves the bloodstream
Externí odkaz:
https://doaj.org/article/c845d9c7df234dc393611ec99844bbde
Autor:
Tetsuya Kawamura, Bryan Stephens, Ling Qin, Xin Yin, Michael R Dores, Thomas H Smith, Neil Grimsey, Ruben Abagyan, Joann Trejo, Irina Kufareva, Mark M Fuster, Catherina L Salanga, Tracy M Handel
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e81454 (2014)
Chemokines control cell migration in many contexts including development, homeostasis, immune surveillance and inflammation. They are also involved in a wide range of pathological conditions ranging from inflammatory diseases and cancer, to HIV. Chem
Externí odkaz:
https://doaj.org/article/a81e519e6a2349f3bedf602dc0a41d9d
Publikováno v:
Molecular Biology of the Cell.
The α-arrestin ARRDC3 is a recently discovered tumor suppressor in invasive breast cancer that functions as a multi-faceted adaptor protein to control protein trafficking and cellular signaling. However, the molecular mechanisms which control ARRDC3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce7352d85003e41fec869bf17c2e80c2
https://doi.org/10.1091/mbc.e23-02-0055
https://doi.org/10.1091/mbc.e23-02-0055