Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Jo-Ann Wentland"'
Autor:
Christopher T. Winkelmann, Rachel Roach, Dangshe Ma, Lindsay King, Mauricio Leal, Mary E. Spilker, Antonio Esparza, Cedo M. Bagi, Parul Gupta, Jo-Ann Wentland, Anand Giddabasappa
Publikováno v:
Oncotarget
// Parul Gupta 1 , Jo-Ann Wentland 2 , Mauricio Leal 2 , Dangshe Ma 3, 6 , Rachel Roach 4 , Antonio Esparza 5 , Lindsay King 2 , Mary E. Spilker 2 , Cedo Bagi 1 , Christopher T. Winkelmann 1 and Anand Giddabasappa 1 1 Global Science and Technology, C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f6b1ff45309c44998eb438ff2a2ca42
https://doi.org/10.18632/oncotarget.19569
https://doi.org/10.18632/oncotarget.19569
Autor:
Chad Ray, Aidong Wu, Kathleen Pelletier, Lindsay King, Yiqun Zhang, Allison Given Chunyk, Tracey Clark, Alison Joyce, Jo-Ann Wentland, Petar Pop-Damkov, Elizabeth A. Dreher, Laurie Tylaska, Phillip D. Yates
Publikováno v:
The AAPS journal. 18(5)
There are many sources of analytical variability in ligand binding assays (LBA). One strategy to reduce variability has been duplicate analyses. With recent advances in LBA technologies, it is conceivable that singlet analysis is possible. We retrosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5963af49513f67c465b0440f35182dcd
https://pubmed.ncbi.nlm.nih.gov/27401185
https://pubmed.ncbi.nlm.nih.gov/27401185
Autor:
Mary E. Spilker, Rand Norberg, Mauricio Leal, Vijay Gupta, Parul Gupta, Anand Giddabasappa, Jeetendra Eswaraka, Jo-Ann Wentland, Puja Sapra, Brian Rago
Publikováno v:
Molecular cancer therapeutics. 15(10)
Understanding a drug's whole-body biodistribution and tumor targeting can provide important information regarding efficacy, safety, and dosing parameters. Current methods to evaluate biodistribution include in vivo imaging technologies like positron
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c13e2c2dbcabce9872107da7ee75243
https://pubmed.ncbi.nlm.nih.gov/27466353
https://pubmed.ncbi.nlm.nih.gov/27466353
Autor:
Mauricio Leal, Nicole Duriga, Judy Lucas, Franklin Spriggs, Eugene P. Kadar, Brian Rago, Jo-Ann Wentland, Quazi Shakey, Xiaogang Han, Wei Song, Jim McNally, Leslie G. Lorello, Yanhua Zhang, Puja Sapra
Publikováno v:
Bioconjugate chemistry. 26(11)
The pharmacokinetics of an antibody (huA1)-drug (auristatin microtubule disrupting MMAF) conjugate, targeting 5T4-expressing cells, were characterized during the discovery and development phases in female nu/nu mice and cynomolgus monkeys after a sin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d25789a1784a3ef9e7205d6f1b0ec4a0
https://pubmed.ncbi.nlm.nih.gov/26180901
https://pubmed.ncbi.nlm.nih.gov/26180901
Autor:
Mauricio Leal, Lindsay King, Dhaval K. Shah, Judy Lucas, Nahor Haddish-Berhane, Xiaogang Han, Jo-Ann Wentland, Alison Betts, Yanhua Zhang
The objectives of this investigation were as follows: (a) to validate a mechanism-based pharmacokinetic (PK) model of ADC for its ability to a priori predict tumor concentrations of ADC and released payload, using anti-5T4 ADC A1mcMMAF, and (b) to an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54424a3c030c8ecaf1488088a040daec
https://europepmc.org/articles/PMC4012047/
https://europepmc.org/articles/PMC4012047/
Publikováno v:
Biopharmaceutics & Drug Disposition. 20:429-439
The pharmacokinetics of ezlopitant were determined in the rat, gerbil, guinea pig, ferret, dog and monkey after intravenous and oral administration. In general, ezlopitant is marked by high clearance values that approach or exceed hepatic blood flow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a766f35ec542014ba9f3a3824268bfa
https://doi.org/10.1002/1099-081x(199912)20:9<429::aid-bdd209>3.0.co
https://doi.org/10.1002/1099-081x(199912)20:9<429::aid-bdd209>3.0.co
Autor:
Kathleen M. Wood, Tarek A. Samad, YeQing Pi, Jo-Ann Wentland, David Caouette, Nikolay Pozdnyakov, Kelly R. Bales, Sharon M. O’Neill, Martin M. Bednar
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6651765a4d262a6ea434ddb00d55c935
https://doi.org/10.1016/j.jalz.2013.05.1692
https://doi.org/10.1016/j.jalz.2013.05.1692
Publikováno v:
Alzheimer's & Dementia. 5
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4592f0a5b241829d3a0117ec582b653
https://doi.org/10.1016/j.jalz.2009.04.944
https://doi.org/10.1016/j.jalz.2009.04.944
Autor:
Mauricio Leal, John F. DiJoseph, Hans-Peter Gerber, George Hu, Judy Lucas, Jenny Zhang, Puja Sapra, John M. Marcek, Jo-Ann Wentland, Elizabeth Groeber, Kiran Khandke, Xiaognag Han, Tracey Clark
Publikováno v:
Molecular Cancer Therapeutics. 10:C117-C117
The pharmacokinetics of a novel antibody (huA1)-drug (auristatin tubulin inhibitor MMAF) conjugate, targeting 5T4-expressing cells, were obtained in female nu/nu mice after a single IV dose of 1, 3 or 10 mg/kg and in male cynomolgus monkeys from a 2-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6910aa3c8475d4826ccba1dc94f9deaa
https://doi.org/10.1158/1535-7163.targ-11-c117
https://doi.org/10.1158/1535-7163.targ-11-c117