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Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study

Autor: Gill Mundin, Kevin Smith, John Strang, Rebecca McDonald, Ulrike Lorch, Björn Bosse, Jo Woodward, Helen Dooner

Publikováno v: Addiction. 113:484-493

Background and Aims Take-home naloxone can prevent death from heroin/opioid overdose, but pre-provision is difficult because naloxone is usually given by injection. Non-injectable alternatives, including naloxone nasal sprays, are currently being dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df03583afab3712b24ab895eb1e266ae
https://doi.org/10.1111/add.14033

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Pulmonary deposition of fluticasone propionate/formoterol in healthy volunteers, asthmatics and COPD patients with a novel breath-triggered inhaler

Autor: Bärbel Huber, Mark Lomax, Dominik Kappeler, Claudius Kietzig, Jo Woodward, Knut Sommerer, Prashant S Dalvi

Publikováno v: Respiratory medicine. 138

Introduction A combination of fluticasone propionate/formoterol fumarate (FP/FORM) has been incorporated within a novel, breath-triggered device, named K-haler®. This low resistance device requires a gentle inspiratory effort to actuate it, triggeri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::363aaee460c0929c445ca299ea1b8416
https://pubmed.ncbi.nlm.nih.gov/29724381

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Systemic bioavailability (BA) and pharmacodynamics (PD) of fluticasone propionate/formoterol (FP/FORM) via pressurised metered-dose inhaler (pMDI) or a novel breath-triggered inhaler (BTI)

Autor: Derek Bell, Gill Mundin, Sanjeeva Dissanayake, Prashant S Dalvi, Jo Woodward, Mark Lomax

Publikováno v: Airway Pharmacology and Treatment.

Background: Two-stage (S1, S2) adaptive design study to compare systemic BA and PD of FP and FORM via the BTI (Flutiform® K-haler®), and pMDI with (+S) or without a spacer (EudraCT: 2013-000045-39). Methods: Single-dose, randomised, open-label cros

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::30d8ba1715399fc51602a0566ba1970c
https://doi.org/10.1183/1393003.congress-2017.pa3950

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Lung deposition of fluticasone propionate/formoterol administered via a breath-triggered inhaler

Autor: Knut Sommerer, Jo Woodward, Mark Lomax, Bärbel Huber, Claudius Kietzig, Dominik Kappeler, Prashant S Dalvi

Publikováno v: Airway Pharmacology and Treatment.

Introduction: Inhaled drug efficacy is dependent on adequate pulmonary drug deposition. A scintigraphic study was undertaken to assess in vivo pulmonary deposition for a novel fluticasone propionate/formoterol (FP/FORM) breath-triggered inhaler (BTI;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::47961ac8254ab030d12bcd7005da2bb5
https://doi.org/10.1183/1393003.congress-2017.pa522

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Relative pulmonary bioavailability (BA) of fluticasone propionate/formoterol (FP/FORM) via pressurised metered-dose inhaler (pMDI) and a novel breath-triggered inhaler (BTI)

Autor: Tim Overend, Jo Woodward, Sanjeeva Dissanayake, Mark Lomax, Gill Mundin, Derek Bell

Publikováno v: Airway Pharmacology and Treatment.

Background: This study aimed to show that pulmonary BA of FP and FORM via the BTI (Flutiform® K‑haler®) was no less than via pMDI without a spacer, to establish a bridge from the efficacy of the pMDI to the BTI (EudraCT: 2012-003728-19). Methods:

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a55b6cd8457534b7fe06cc07ba6c2f6
https://doi.org/10.1183/1393003.congress-2017.pa523

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Pharmacokinetics of concentrated naloxone nasal spray for opioid overdose reversal: Phase I healthy volunteer study

Autor: Rebecca, McDonald, Ulrike, Lorch, Jo, Woodward, Björn, Bosse, Helen, Dooner, Gill, Mundin, Kevin, Smith, John, Strang

Publikováno v: Addiction (Abingdon, England). 113(3)

Take-home naloxone can prevent death from heroin/opioid overdose, but pre-provision is difficult because naloxone is usually given by injection. Non-injectable alternatives, including naloxone nasal sprays, are currently being developed. To be effect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::76219b9d4a1d150c53dd9fef747cfed2
https://pubmed.ncbi.nlm.nih.gov/29423984

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Naloxone as part of a prolonged release oxycodone/naloxone combination reduces oxycodone-induced slowing of gastrointestinal transit in healthy volunteers

Autor: Jo Woodward, Ann Church, Simon Bond, Karuppan Palaniappan, Kevin Smith, Alyson Connor, Paul Bailey, Gill Mundin, Michael Hopp, Marie C. Limb

Publikováno v: Expert Opinion on Investigational Drugs. 20:427-439

This exploratory study in healthy volunteers investigated the effect of single doses of oxycodone on gastrointestinal (GI) transit time and the degree to which a single dose of naloxone reverses the oxycodone-induced effect.Fifteen healthy male volun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa8b24a56a325eae7324f92dc5c21bd5
https://doi.org/10.1517/13543784.2011.563236

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Low absolute bioavailability of oral naloxone in healthy subjects

Autor: Michael Hopp, Simon Bond, Kevin Smith, Paul Bailey, Gill Mundin, Jo Woodward, David Bell

Publikováno v: International journal of clinical pharmacology and therapeutics. 50(5)

Objective To determine the absolute bioavailability of naloxone from oral doses ranging from 5 mg to 120 mg. Materials and methods In this open-label study, 28 healthy subjects received naloxone 1 mg (0.4 mg/ml) as an intravenous infusion (reference

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25aad7963d6b6cd769d6f32c635f71ca
https://pubmed.ncbi.nlm.nih.gov/22541841

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