Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Jo Vercammen"'
Autor:
Guus A.M.S. van Dongen, Hilde Revets, Marijke Stigter-van Walsum, Joost A. Kolkman, Jo Vercammen, Maria J.W.D. Vosjan
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Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509184f8ff03940803235e56852365f2
https://doi.org/10.1158/1535-7163.22498978
https://doi.org/10.1158/1535-7163.22498978
Autor:
Jo Vercammen, Zeger Debyser, Yves Engelborghs, Anneleen Hombrouck, Martine Michiels, Myriam Witvrouw, Anke Hantson, D. Rhodes, Victor Tetz, B. van Remoortel, Frauke Christ
Publikováno v:
Journal of Antimicrobial Chemotherapy. 59:1084-1095
Objectives: We have previously identified the pyranodipyrimidines (PDPs) as a new class of integrase (IN) inhibitors. The most potent congener V-165 inhibits HIV-1 integration at low micromolar concentrations by inhibiting the binding of IN to the DN
Autor:
Jo Vercammen, Jan De Rijck, Anneleen Hombrouck, Zeger Debyser, Jelle Hendrix, Frauke Christ, Yves Engelborghs, Linos Vandekerckhove, Rik Gijsbers
Publikováno v:
Journal of Virology. 80:11498-11509
We initially identified lens epithelium-derived growth factor/p75 (LEDGF/p75) as a binding partner of human immunodeficiency virus type 1 (HIV-1) integrase. To investigate the role of LEDGF/p75 in HIV replication and its potential as a new antiviral
Autor:
Yves Engelborghs, Jorina Geys, Lieve Coenegrachts, Abderrahim Nemmar, Benoit Nemery, Jo Vercammen, Peter Hoet
Publikováno v:
Toxicology Letters. 160:218-226
Recent studies indicate that inhaled ultrafine particles can pass into the circulation. To study this translocation in an in vitro model three types of pulmonary epithelial cells were examined. The integrity of the cell monolayer was verified by meas
Autor:
Stéphane Emiliani, Jo Vercammen, Katrien Busschots, Yves Engelborghs, Richard Benarous, Zeger Debyser, Frauke Christ
Publikováno v:
Journal of Biological Chemistry. 280:17841-17847
We have previously shown that the p75 isoform of the transcriptional co-activator lens epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency virus (HIV)-1 integrase (IN) and is essential for nuclear targeting of this
Publikováno v:
Current Medicinal Chemistry -Anti-Infective Agents. 4:153-165
Current strategies for the treatment of human immunodeficiency virus (HIV) infection are based on cocktails of drugs that target the viral entry step and the enzymes reverse transcriptase or protease. At present, the clinical benefit of this combinat
Autor:
Johan Hofkens, Jo Vercammen, Mario Smet, Ramesh Shukla, Frans C. De Schryver, Bert Metten, Wim Dehaen, W. Verheijen, Yves Engelborghs
Publikováno v:
Macromolecular Chemistry and Physics. 206:25-32
The photophysical properties of dendrimers with 1,4-dioxo-3,6-diphenylpyrrolo[3,4-c]pyrrole, also known as DPP, as a core were studied. DPP itself has a high quantum yield of fluorescence, as well as a high molar decadic absorption coefficient, e (e
Autor:
Johan Hofkens, Jo Vercammen, Yves Engelborghs, Frans C. De Schryver, Jianqiang Qu, Christopher Kohl, Thomas Gensch, Mircea Cotlet, Anca Margineanu, Satoshi Habuchi, Alina Stefan, Klaus Müllen
Publikováno v:
The journal of physical chemistry / B 108, 12242-12251 (2004). doi:10.1021/jp048051w
The photophysical properties of a new water-soluble fluorescent dye based on the perylene diimide chromophore are investigated at the ensemble and single molecule level. Water solubility was obtained by attaching hydrophilic substiments in the bay re
Autor:
Scott Hobson, Jo Vercammen, Martin Lenter, Katja S. Kroker, Holger Rosenbrock, Gerald Beste, Thorsten Lamla, Pascal Merchiers, Cornelia Dorner-Ciossek
Publikováno v:
Alzheimer's & Dementia. 10
Publikováno v:
The FASEB Journal. 19:1039-1041
Recently we described the interaction of human immunodeficiency virus type 1 (HIV-1)1 integrase (IN) with a cellular protein, lens epithelium-derived growth factor/transcription co-activator p75 (LEDGF/p75). We now present the study of the diffusion