Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Jo Van Ginderachter"'
Autor:
Fang Zheng, Jinhong Zhou, Zhenlin Ouyang, Jiaxin Zhang, Xinyi Wang, Serge Muyldermans, Jo Van Ginderachter, Nick Devoogdt, Yurong Wen, Steve Schoonooghe, Geert Raes
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Nanobodies that are derived from single-chain antibodies of camelids have served as powerful tools in diagnostics, therapeutics and investigation of membrane receptors' structure and function. In this study, we developed a series of nanobodies by a p
Externí odkaz:
https://doaj.org/article/26d23f5c298d4bee9151890c8653099c
Autor:
Timo De Groof, Yoline Lauwers, Tessa De Pauw, Cécile Vincke, Jolien Van Craenenbroeck, Geert Raes, Jo Van Ginderachter, Devoogdt Nick
Publikováno v:
Vrije Universiteit Brussel
Introduction The presence and activity profile of tumor-infiltrating immune cells may predict responsiveness to (immuno)therapy. More specifically, CD8+ cytotoxic T cells are believed to be the main effector cells during anti-cancer responses. Theref
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::272c888ffca093a292611a46de2370a9
https://hdl.handle.net/20.500.14017/5c4080d9-9854-4844-a1b0-e94019f240da
https://hdl.handle.net/20.500.14017/5c4080d9-9854-4844-a1b0-e94019f240da
Autor:
Jo Van Ginderachter
Publikováno v:
Cancer Research. 82:3882-3883
Immunotherapy of cancer is a burgeoning field of research since the realization that our immune system intrinsically has the capacity to restrict tumor occurrence and progression. Though strategies to maximize antitumor T-cell activation are well est
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a44f2573261107417022e5c7dbba202
https://doi.org/10.1158/0008-5472.can-22-2774
https://doi.org/10.1158/0008-5472.can-22-2774
Publikováno v:
Vrije Universiteit Brussel
Chemotherapy has been a standard treatment for cancer for the past several decades and has long been suspected to cause systemic immune suppression. However, in recent years it has become clear that the immune status of a patient is an independent pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d5c5f510f19644af2d27b181127fa1f2
https://hdl.handle.net/20.500.14017/b0f1afb0-072f-410f-98f0-5005c8d151be
https://hdl.handle.net/20.500.14017/b0f1afb0-072f-410f-98f0-5005c8d151be
Publikováno v:
Vrije Universiteit Brussel
E-cadherin is best known as a central molecule in adherens junctions, joining adjacent epithelial cells together, thereby safeguarding epithelial barrier function. However, recent findings have uncovered an immunological role for this adhesion molecu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::004ec295da7c8c23f52c67eea6633892
https://biblio.vub.ac.be/vubir/ecadherin-from-epithelial-glue-to-immunological-regulator(0e4fa67a-17fb-4feb-9aef-f4ed38ab6cf5).html
https://biblio.vub.ac.be/vubir/ecadherin-from-epithelial-glue-to-immunological-regulator(0e4fa67a-17fb-4feb-9aef-f4ed38ab6cf5).html
Autor:
Jo Van Ginderachter
Publikováno v:
Vrije Universiteit Brussel
Interaction between malignant cells and their surrounding tissue plays a crucial role in tumor growth, invasiveness and spreading to the distant organs. New findings provide evidence of a principal importance of the immune cells for controlling this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::03b2e25fda41b63f4449c66a1a696702
https://biblio.vub.ac.be/vubir/macrophage-differentiation-and-activiation-states-in-the-tumor-microenvironment(2ca8ea87-ee18-4f47-a83a-03d9fe2d0156).html
https://biblio.vub.ac.be/vubir/macrophage-differentiation-and-activiation-states-in-the-tumor-microenvironment(2ca8ea87-ee18-4f47-a83a-03d9fe2d0156).html
Autor:
Jan Van Den Bossche, Damya Laoui, Yannick Morias, Kiavash Movahedi, Geert Raes, Patrick De Baetselier, Jo Van Ginderachter
Publikováno v:
Vrije Universiteit Brussel
Macrophages altered by various Th2-associated and anti-inflammatory mediators - including IL-4 and IL-13 (inducing alternatively activated macrophages [AAMs]), IL-10 and TGF-? - were generically termed M2. However, markers which discriminate between
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d054aca88c9188d380f87aff580d23fe
https://biblio.vub.ac.be/vubir/claudin1-claudin2-and-claudin11-genes-differentially-associate-with-distinct-types-of-antiinflammatory-macrophages-in-vitro-and-with-parasite-and-tumorelicited-macrophages-in-vivo(0355c2cf-de12-4901-b871-d4f73b632e9d).html
https://biblio.vub.ac.be/vubir/claudin1-claudin2-and-claudin11-genes-differentially-associate-with-distinct-types-of-antiinflammatory-macrophages-in-vitro-and-with-parasite-and-tumorelicited-macrophages-in-vivo(0355c2cf-de12-4901-b871-d4f73b632e9d).html
Autor:
Charlotte Rolny, Massimiliano Mazzone, Sonia Tugues, Damya Laoui, Irja Johansson, Cathy Coulon, Mario Leonardo Squadrito, Immaculada Segura, Xiujuan Li, Ellen Knevels, Sandra Costa, Stefan Vinckier, Tom Dresselaer, Peter Akerud, Maria De Mol, Henrikka Salomaki, Mia Philipson, Wyns Sabine, Erik Larsson, Ian Buysschaert, Johan Botling, Uwe Himmelreich, Jo Van Ginderachter, Michele De Palma, Dewerchin, M., Lena Claesson-Welsh, Peter Carmeliet
Publikováno v:
Vrije Universiteit Brussel
Polarization of tumor-associated macrophages (TAMs) to a proangiogenic/immune-suppressive (M2-like) phenotype and abnormal, hypoperfused vessels are hallmarks of malignancy, but their molecular basis and interrelationship remains enigmatic. We report
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::7f13f46db0f2efa8bc2507a6e824a177
https://hdl.handle.net/20.500.14017/674e9325-5953-486e-9f94-6fbe4ff0695b
https://hdl.handle.net/20.500.14017/674e9325-5953-486e-9f94-6fbe4ff0695b
Autor:
Jo Van Ginderachter, Sofie Meerschaut, Yuanqing Liu, Lea Brys, Kurt De Groeve, Gholamreza Hassanzadeh Ghassabeh, Geert Raes, Patrick De Baetselier
Publikováno v:
Vrije Universiteit Brussel
Tumors may escape from immune control by the induction of CD11b(+)Gr-1(+) myeloid suppressor cells in the spleen. In this study, we demonstrate that this cell population can be subdivided into a CD11b(hi)Gr-1(int)SSC(lo)Ly6G(neg)M-CSFR(int) immature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::1416132eee8eedcda571ee1536d8228b
https://biblio.vub.ac.be/vubir/peroxisome-proliferatoractivated-receptorgamma-ppargamma-ligands-reverse-ctl-suppression-by-alternatively-activated-m2-macrophages-in-cancer(f9c04dc1-1b44-4682-8253-371ca8dc454c).html
https://biblio.vub.ac.be/vubir/peroxisome-proliferatoractivated-receptorgamma-ppargamma-ligands-reverse-ctl-suppression-by-alternatively-activated-m2-macrophages-in-cancer(f9c04dc1-1b44-4682-8253-371ca8dc454c).html
Autor:
Jo Van Ginderachter
Publikováno v:
Vrije Universiteit Brussel
In this issue of Blood, Willenborg and colleagues uncover the timeline of monocyte/macrophage involvement during sequential phases of skin wound healing. The CCR2-mediated recruitment of a vascular endothelial growth factor A(VEGF-A)–expressing inf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f392ea85860329df41b0205738c77587
https://doi.org/10.1182/blood-2012-05-430660
https://doi.org/10.1182/blood-2012-05-430660