Continuous Positive Airway Pressure plus Mandibular Advancement Therapy (PAPMAT): study protocol for an adaptive randomised crossover trial comparing the benefits and costs of combining two established treatments for obstructive sleep apnoea

Autor: Martin Law, Sofia Villar, Nicholas Oscroft, Victoria Stoneman, Julia Fox-Rushby, Yi-Da Chiu, Jo Steele, Thomas Devine, Claire Francis, Thomas Claydon, Graham Hill, Ka Keat Lim, Joanna Rayner, Mandy Williams, Emma Spires, Timothy Quinnell

Publikováno v: Trials, Vol 24, Iss 1, Pp 1-14 (2023)

Abstract Background Obstructive sleep apnoea (OSA) involves repeated breathing pauses during sleep due to upper airway obstruction. It causes excessive daytime sleepiness and has other health impacts. Continuous positive airway pressure (CPAP) therap

Externí odkaz: https://doaj.org/article/16de8a94079c41db95bc362006a2c8f9

Assessment of Response to Lithium Maintenance Treatment in Bipolar Disorder: A Consortium on Lithium Genetics (ConLiGen) Report.

Autor: Mirko Manchia, Mazda Adli, Nirmala Akula, Raffaella Ardau, Jean-Michel Aubry, Lena Backlund, Claudio Em Banzato, Bernhard T Baune, Frank Bellivier, Susanne Bengesser, Joanna M Biernacka, Clara Brichant-Petitjean, Elise Bui, Cynthia V Calkin, Andrew Tai Ann Cheng, Caterina Chillotti, Sven Cichon, Scott Clark, Piotr M Czerski, Clarissa Dantas, Maria Del Zompo, J Raymond Depaulo, Sevilla D Detera-Wadleigh, Bruno Etain, Peter Falkai, Louise Frisén, Mark A Frye, Jan Fullerton, Sébastien Gard, Julie Garnham, Fernando S Goes, Paul Grof, Oliver Gruber, Ryota Hashimoto, Joanna Hauser, Urs Heilbronner, Rebecca Hoban, Liping Hou, Stéphane Jamain, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, John R Kelsoe, Sarah Kittel-Schneider, Sebastian Kliwicki, Po-Hsiu Kuo, Ichiro Kusumi, Gonzalo Laje, Catharina Lavebratt, Marion Leboyer, Susan G Leckband, Carlos A López Jaramillo, Mario Maj, Alain Malafosse, Lina Martinsson, Takuya Masui, Philip B Mitchell, Frank Mondimore, Palmiero Monteleone, Audrey Nallet, Maria Neuner, Tomás Novák, Claire O'Donovan, Urban Osby, Norio Ozaki, Roy H Perlis, Andrea Pfennig, James B Potash, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Sara Richardson, Guy A Rouleau, Janusz K Rybakowski, Martin Schalling, Peter R Schofield, Oliver K Schubert, Barbara Schweizer, Florian Seemüller, Maria Grigoroiu-Serbanescu, Giovanni Severino, Lisa R Seymour, Claire Slaney, Jordan W Smoller, Alessio Squassina, Thomas Stamm, Jo Steele, Pavla Stopkova, Sarah K Tighe, Alfonso Tortorella, Gustavo Turecki, Naomi R Wray, Adam Wright, Peter P Zandi, David Zilles, Michael Bauer, Marcella Rietschel, Francis J McMahon, Thomas G Schulze, Martin Alda

Publikováno v: PLoS ONE, Vol 8, Iss 6, p e65636 (2013)

The assessment of response to lithium maintenance treatment in bipolar disorder (BD) is complicated by variable length of treatment, unpredictable clinical course, and often inconsistent compliance. Prospective and retrospective methods of assessment

Externí odkaz: https://doaj.org/article/0ef98b50bc7c4ff285a1c918c187d4f2

The role of Glucagon-Like Peptide 1 Loading on periprocedural myocardial infarction During elective PCI (GOLD-PCI study): A randomized, placebo-controlled trial

Autor: Nick E.J. West, Liam M. McCormick, Sofia S. Villar, Tian Zhao, Sarah C. Clarke, David Adlam, Jo Steele, Sarah Fielding, Cameron G. Densem, Joel P. Giblett, Michael O'Sullivan, Sophie J. Clarke, Stephen P. Hoole, Denise Braganza

Publikováno v: American Heart Journal. 215:41-51

Background The incretin hormone glucagon-like peptide 1 (GLP-1) has been shown to protect against lethal ischemia-reperfusion injury in animal models and against nonlethal ischemia reperfusion injury in humans. Furthermore, GLP-1 receptor agonists ha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be462517eab24fd48198e4456eb73362
https://doi.org/10.1016/j.ahj.2019.05.013

TICAGRELOR DOES NOT MEDIATE ITS EARLY BENEFICIAL EFFECTS IN ST-ELEVATION MYOCARDIAL INFARCTION BY IMPROVING CORONARY MICROVASCULAR DYSFUNCTION – THE TIMES DOUBLE-BLIND RANDOMISED CONTROLLED TRIAL

Autor: Stephen P. Hoole, Muhammad Aetesam-ur-Rahman, Yi-Da Chiu, Tian Zhao, Kitty Paques, Joana Oliveira, Jo Steele, Melissa Duckworth, Sarah Fielding, Nick E. West

Publikováno v: Journal of the American College of Cardiology. 79:614

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c7ecbe8fe5ef64ccb230f2ad873a2d22
https://doi.org/10.1016/s0735-1097(22)01605-9

Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder

Autor: Jo Steele, Jordan W. Smoller, J. Raymond DePaulo, Shaun Purcell, Marian L. Hamshere, Francis J. McMahon, Mehdi Pirooznia, Pamela B. Mahon, Marcella Rietschel, Sven Cichon, Hugh Gurling, Jie Huang, John R. Kelsoe, Fernando S. Goes, Thomas G. Schulze, Phil Lee, Nicholas John Craddock, James B. Potash, Fayaz Seifuddin, Markus M. Nöthen, Peter P. Zandi

Publikováno v: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 156:370-378

Genome-wide association studies (GWAS) have identified several susceptibility loci for bipolar disorder (BP), most notably ANK3. However, most of the inherited risk for BP remains unexplained. One reason for the limited success may be the genetic het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cfb74b5d315fefbaf1803819d6493bb
https://doi.org/10.1002/ajmg.b.31172