Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Jo Mahoney"'
1
Hepatocyte PHB1 Deficiency Causes Sex-Specific Changes in Glycemic Control and Body Composition in Mice
Autor: Amany Alowaisi, Jo Mahoney, Islam Berdaweel, Ethan Anderson
Publikováno v: Physiology. 38
Prohibitin 1 (PHB1) is a dynamic lipid raft associated protein that is located in plasma membrane and in the inner mitochondrial membrane complexed with its homolog PHB2 in a tight 1:1 stoichiometric ratio. The PHB1/2 ‘supercomplex’ has been link
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::98f3ff71c65cb150ffa42b7a41e21643
https://doi.org/10.1152/physiol.2023.38.s1.5733979
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2
Oral Carnosine Supplementation Restores Insulin Sensitivity but not Glucose Tolerance in Mice With Glutathione Peroxidase-4 Deficiency
Autor: Islam Berdaweel, Jo Mahoney, Amany Alowaisi, Kaitlyn Berns, Ethan Anderson
Publikováno v: Physiology. 38
Obesity presents in about 90% of the diabetic patients, a risk factor that makes them more susceptible to cardiometabolic disorders, particularly insulin resistance and ultimately T2 diabetes. Increased oxidative stress and specifically lipid peroxid
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7cc42d5df365199c30a71ba2c37a6e68
https://doi.org/10.1152/physiol.2023.38.s1.5795984
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3
Abstract 556: Deficiency of Probhitin-1 in Hepatocytes Alters Systemic Glucose Regulation
Autor: Katie Weihbrecht, Jo Mahoney, Ethan J Anderson
Publikováno v: Circulation Research. 127
Prohibitins 1 and 2 (PHB1 and PHB2) are lipid raft proteins that form a hetero-oligomeric complex known to localize to the cytoplasmic, nuclear, and mitochondrial membranes. These complexes play important roles in pro-survival and metabolic decisions
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::221aa2e7b6b7ed6ff1ae1afd3ec692d6
https://doi.org/10.1161/res.127.suppl_1.556
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4
Genetic Absence of nNOS Worsens Fetal Alcohol Effects in Mice. II: Microencephaly and Neuronal Losses
Autor: Jeffrey M. Plume, Daniel J. Bonthius, Jo Mahoney, Bahri Karacay
Publikováno v: Alcoholism: Clinical and Experimental Research. 39:221-231
Prenatal alcohol exposure can kill developing neurons, leading to microencephaly and mental retardation. However, not all fetuses are equally vulnerable to alcohol's neurotoxic effects. While some fetuses are severely affected and are ultimately diag
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d656355eb3c7d390637cf63580dd883f
https://doi.org/10.1111/acer.12615
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5
Severe alcohol-induced neuronal deficits in the hippocampus and neocortex of neonatal mice genetically deficient for neuronal nitric oxide synthase (nNOS)
Autor: Daniel J. Bonthius, Harb Harb, Bahri Karacay, Ana Hutton Kehrberg, Ross A. MCkim, Nicholas J. Pantazis, Jo Mahoney, Lindsey Koele
Publikováno v: The Journal of Comparative Neurology. 499:290-305
Alcohol can severely damage the developing brain, and neuronal loss is a critical component of this injury. Thus, identification of molecular factors that ameliorate alcohol-induced neuronal loss is of great importance. Previous in vitro work has dem
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef548b19cdf10058ec1f941ebbcfa4e3
https://doi.org/10.1002/cne.21095
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6
Use of frozen sections to determine neuronal number in the murine hippocampus and neocortex using the optical disector and optical fractionator
Autor: Daniel J. Bonthius, Jo Mahoney, Harb Harb, Ross McKim, Bahri Karacay, Lindsey Koele, Nicholas J. Pantazis
Publikováno v: Brain Research Protocols. 14:45-57
Stereology is an important technique for the quantification of neurons in subregions of the central nervous system. A commonly used method of stereology relies upon embedment of tissue in glycol methacrylates to allow production of sections that are
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7096fdfe63e0bce4e28e90900c1471e7
https://doi.org/10.1016/j.brainresprot.2004.09.003
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8
A single exposure to alcohol during brain development induces microencephaly and neuronal losses in genetically susceptible mice, but not in wild type mice
Autor: Hannah Klein de Licona, Elizabeth McDonald, Daniel J. Bonthius, Thirath Luang, Bahri Karacay, Jo Mahoney
Publikováno v: Neurotoxicology. 30(3)
Maternal alcohol abuse during pregnancy can damage the fetal brain and lead to fetal alcohol syndrome (FAS). Despite public warnings discouraging alcohol use during pregnancy, many pregnant women continue to drink intermittently because they do not b
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::998cb32f3a6b993ed5bba80f7564acfb
https://pubmed.ncbi.nlm.nih.gov/19442832
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9
Lymphocytic choriomeningitis virus infection of the developing brain: critical role of host age
Autor: Harb Harb, Daniel J. Bonthius, Jo Mahoney, Brent Nichols, Bahri Karacay
Publikováno v: Annals of neurology. 62(4)
Objective Lymphocytic choriomeningitis virus (LCMV) is a common human pathogen that causes substantial injury to the developing brain when the infection occurs during pregnancy. However, among children with congenital LCMV infection, there is conside
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b063eec09bc2529a6cf62917b5f5ec
https://pubmed.ncbi.nlm.nih.gov/18409198
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