Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Jo L. Latimer"'
Autor:
George A. Syrogiannopoulos, Ahmed S. Attia, Jo L. Latimer, Eric R. Lafontaine, Christoph Aebi, Eric J. Hansen
Publikováno v:
Infection and Immunity. 73:2400-2410
Many strains of Moraxella catarrhalis are resistant to the bactericidal activity of normal human serum. Previous studies have shown that mutations involving the insertion of an antibiotic resistance cartridge into the M. catarrhalis uspA2 gene result
Autor:
Kate R. Fortney, Barry P. Katz, Merja Väkeväinen, Jo L. Latimer, Jason R. Mock, Stanley M. Spinola, Eric J. Hansen
Publikováno v:
Infection and Immunity. 71:7178-7182
An intact Haemophilus ducreyi flp operon is essential for microcolony formation in vitro. tadA is the 9th of 15 genes in the operon and has homology to NTPases of type IV secretion systems. Fifteen human volunteers were experimentally infected with b
Autor:
David A. Lewis, Robert J. Blick, Eric J. Hansen, Marla K. Stevens, Jo L. Latimer, Christine K. Ward, Sheryl R. Lumbley, Catherine A Ison, Kaiping Deng
Publikováno v:
Infection and Immunity. 69:5626-5634
Haemophilus ducreyiexpresses a soluble cytolethal distending toxin (CDT) that is encoded by thecdtABCgene cluster and can be detected in culture supernatant fluid by its ability to kill HeLa cells. ThecdtA, cdtB, andcdtCgenes ofH. ducreyiwere cloned
Publikováno v:
Biochemical and Biophysical Research Communications. 285:609-615
The cytolethal distending toxin (CDT) of Haemophilus ducreyi is encoded by the cdtABC genes, but the composition of active CDT is not known. Both immunoaffinity and metal affinity chromatographic methods were used to purify H. ducreyi CDT from recomb
Autor:
Leslie D. Cope, Eric R. Lafontaine, Jo L. Latimer, Eric J. Hansen, George H. McCracken, Christoph Aebi
Publikováno v:
Journal of Bacteriology. 182:1364-1373
The UspA1 and UspA2 proteins of Moraxella catarrhalis are structurally related, are exposed on the bacterial cell surface, and migrate as very high-molecular-weight complexes in sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Previous anal
Autor:
Eric J. Hansen, Christine K. Ward, Sheryl R. Lumbley, Teresa Lagergård, Leslie D. Cope, Marla K. Stevens, Jo L. Latimer
Publikováno v:
Infection and Immunity. 67:3900-3908
Haemophilus ducreyi expresses a soluble cytolethal distending toxin (CDT) that kills HeLa, HEp-2, and other human epithelial cells in vitro. H. ducreyi CDT activity is encoded by a three-gene cluster ( cdtABC ), and antibody to the cdtC gene product
Autor:
Jo L. Latimer, Eric R. Lafontaine, Sheryl L. Lumbley, Leslie D. Cope, Eric J. Hansen, George H. McCracken, Christoph Aebi
Publikováno v:
Infection and Immunity. 66:3113-3119
The UspA surface antigen of Moraxella catarrhalis was recently shown to be comprised of two different proteins (UspA1 and UspA2) which share an internal region containing 140 amino acids with 93% identity (C. Aebi, I. Maciver, J. L. Latimer, L. D. Co
Autor:
Clive A. Slaughter, Sharon E. Thomas, Jo L. Latimer, Christoph Aebi, Leslie D. Cope, George H. McCracken, Eric J. Hansen
Publikováno v:
Infection and Immunity. 66:540-548
A monoclonal antibody (MAb) (MAb 10F3) directed against the CopB outer membrane protein of Moraxella catarrhalis previously was found to enhance pulmonary clearance of M. catarrhalis in an animal model (M. Helminen, I. Maciver, J. L. Latimer, L. D. C
Autor:
Eric J. Hansen, Leslie D. Cope, Christoph Aebi, Sharon E. Thomas, George H. McCracken, Marla K. Stevens, Isobel Maciver, Jo L. Latimer
Publikováno v:
Infection and Immunity. 65:4367-4377
The high-molecular-weight UspA protein of Moraxella catarrhalis has been described as being both present on the surface of all M. catarrhalis disease isolates examined to date and a target for a monoclonal antibody (MAb 17C7) which enhanced pulmonary
Autor:
Leslie D. Cope, Robert S. Munson, Jo L. Latimer, Sheryl R. Lumbley, Linda S. Johnson, Teresa Lagergård, Eric J. Hansen, Marla K. Stevens, Maria Purven, Julia Klesney-Tait, Justin D. Radolf
Publikováno v:
Proceedings of the National Academy of Sciences. 94:4056-4061
Little is known about the virulence mechanisms employed by Haemophilus ducreyi in the production of genital ulcers. This Gram-negative bacterium previously has been shown to produce a soluble cytotoxic activity that kills HeLa and HEp-2 cells. We hav