Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Jo L. Bramhall"'
Autor:
Yasaman KalantarMotamedi, Ran Joo Choi, Siang-Boon Koh, Jo L. Bramhall, Tai-Ping Fan, Andreas Bender
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103080- (2021)
Summary: Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on trans
Externí odkaz:
https://doaj.org/article/69cd70dbe9ff4fdb8050f751b9552302
Autor:
Lasse Stach, Emily K. H. Dinley, Nadia Tournier, Ryan P. Bingham, Darren A. Gormley, Jo L. Bramhall, Adam Taylor, Jane E. Clarkson, Katherine A. Welbeck, Claire L. Harris, Maria Feeney, Jane P. Hughes, Armin Sepp, Thil D. Batuwangala, Semra J. Kitchen, Eva-Maria Nichols
Publikováno v:
Antibodies, Vol 10, Iss 4, p 39 (2021)
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Externí odkaz:
https://doaj.org/article/9c08d3afb4f34afc913b99f6d81d4c48
Autor:
Tai-Ping Fan, Yasaman KalantarMotamedi, Jo L. Bramhall, Andreas Bender, Siang-Boon Koh, Ran Joo Choi
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103080-(2021)
iScience
KalantarMotamedi, Y, Choi, R J, Koh, S-B, Bramhall, J L, Fan, T-P & Bender, A 2021, ' Prediction and identification of synergistic compound combinations against pancreatic cancer cells ', iScience, vol. 24, no. 9, 103080, pp. 103080 . https://doi.org/10.1016/j.isci.2021.103080
iScience
KalantarMotamedi, Y, Choi, R J, Koh, S-B, Bramhall, J L, Fan, T-P & Bender, A 2021, ' Prediction and identification of synergistic compound combinations against pancreatic cancer cells ', iScience, vol. 24, no. 9, 103080, pp. 103080 . https://doi.org/10.1016/j.isci.2021.103080
Summary Resistance to current therapies is common for pancreatic cancer and hence novel treatment options are urgently needed. In this work, we developed and validated a computational method to select synergistic compound combinations based on transc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cd491458d89deec4e44adf2ea8730a2
Autor:
Jane E Clarkson, Nadia Tournier, Ryan P. Bingham, Maria Feeney, Semra Kitchen, Jo L Bramhall, Darren A. Gormley, Lasse Stach, Eva-Maria Nichols, Jane P. Hughes, Katherine A Welbeck, Claire L. Harris, Adam Taylor, Armin Sepp, Thil D. Batuwangala, Emily K H Dinley
Publikováno v:
Antibodies, Vol 10, Iss 39, p 39 (2021)
Antibodies
Volume 10
Issue 4
Antibodies
Volume 10
Issue 4
The terminal pathway of complement is implicated in the pathology of multiple diseases and its inhibition is, therefore, an attractive therapeutic proposition. The practicalities of inhibiting this pathway, however, are challenging, as highlighted by
Autor:
Aurélie Courtin, Frances M Richards, Tashinga E Bapiro, Jo L Bramhall, Albrecht Neesse, Natalie Cook, Ben-Fillippo Krippendorff, David A Tuveson, Duncan I Jodrell
Publikováno v:
PLoS ONE, Vol 8, Iss 6, p e67330 (2013)
Capecitabine (CAP) is a 5-FU pro-drug approved for the treatment of several cancers and it is used in combination with gemcitabine (GEM) in the treatment of patients with pancreatic adenocarcinoma (PDAC). However, limited pre-clinical data of the eff
Externí odkaz:
https://doaj.org/article/e84923692d2b48e9bbd3ce4de3f87151
Autor:
Yao Lin, A. Robertson, Duncan I. Jodrell, Jo L. Bramhall, Jennifer Harrington, Daniella Zheleva, Tashinga E. Bapiro, Frances M. Richards, B-F Krippendorff
Publikováno v:
British Journal of Cancer
BACKGROUND: Amplification of aurora kinase A (AK-A) overrides the mitotic spindle assembly checkpoint, inducing resistance to taxanes. RNA interference targeting AK-A in human pancreatic cancer cell lines enhanced taxane chemosensitivity. In this stu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac2a40840c1c7c497781bc2aeb45ad98
Autor:
Fernando López-Caamal, Duncan I. Jodrell, Frances M. Richards, Ben-Fillippo Krippendorff, Diego A. Oyarzún, Jo L. Bramhall
Publikováno v:
Integr. Biol.. 6:736-742
Cells sense information encoded in extracellular ligand concentrations and process it using intracellular signalling cascades. Using mathematical modelling and high-throughput imaging of individual cells, we studied how a transient extracellular grow
Autor:
Giovanni Y, Di Veroli, Chiara, Fornari, Dennis, Wang, Séverine, Mollard, Jo L, Bramhall, Frances M, Richards, Duncan I, Jodrell
Publikováno v:
Bioinformatics
Motivation: Many drug combinations are routinely assessed to identify synergistic interactions in the attempt to develop novel treatment strategies. Appropriate software is required to analyze the results of these studies. Results: We present Combene
Autor:
Giovanni Y, Di Veroli, Chiara, Fornari, Ian, Goldlust, Graham, Mills, Siang Boon, Koh, Jo L, Bramhall, Frances M, Richards, Duncan I, Jodrell
Publikováno v:
Scientific Reports
In cancer pharmacology (and many other areas), most dose-response curves are satisfactorily described by a classical Hill equation (i.e. 4 parameters logistical). Nevertheless, there are instances where the marked presence of more than one point of i
Autor:
Charlotte A. Ashby, Stephen E. Clarke, Andrew Ayrton, Sandra J. Baldwin, Lin Yue, Jo L. Bramhall, Steven R. Hood, Paul R. Murdock
Publikováno v:
Drug Metabolism and Disposition. 34:1063-1069
Drug-induced changes in expression of cytochrome P450 (P450) genes are a significant issue in the preclinical development of pharmaceuticals. For example, preclinically, P450 induction can affect safety studies by reducing the systemic exposure of a