Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Jo Harnaha"'
Autor:
Valentina Di Caro, Brett Phillips, Carl Engman, Jo Harnaha, Massimo Trucco, Nick Giannoukakis
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83575 (2014)
The objective of the study was to identify immune cell populations, in addition to Foxp3+ T-regulatory cells, that participate in the mechanisms of action of tolerogenic dendritic cells shown to prevent and reverse type 1 diabetes in the Non-Obese Di
Externí odkaz:
https://doaj.org/article/ca0dfff3dd664326bd3a4664520bb5e5
Publikováno v:
Clinical and Experimental Immunology. 174:302-317
Summary While much is known about tolerogenic dendritic cell effects on forkhead box protein 3 (FoxP3)+ regulatory T cells, virtually nothing is known about their effects on another arm of immunoregulation that is mediated by a subpopulation of immun
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19e18b46617c13de1ee1990f9d1356ae
https://doi.org/10.1111/cei.12177
https://doi.org/10.1111/cei.12177
Publikováno v:
Diabetes Care
OBJECTIVE The safety of dendritic cells to selectively suppress autoimmunity, especially in type 1 diabetes, has never been ascertained. We investigated the safety of autologous dendritic cells, stabilized into an immunosuppressive state, in establis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ea723129631140faa78f5e6d70495ad
https://doi.org/10.2337/dc11-0472
https://doi.org/10.2337/dc11-0472
Autor:
Janet Knox, Jo Harnaha, Debra Lafreniere, Kenneth Hogeland, Karen Nylander, Brett E. Phillips, Massimo Trucco, Michael Gallo, Jennifer Machen, Nick Giannoukakis, Robert Lakomy, Alexis Styche, Kimberly A. Gillis, Larry Brown
Publikováno v:
Diabetes. 57:1544-1555
OBJECTIVE—This study was aimed at ascertaining the efficacy of antisense oligonucleotide-formulated microspheres to prevent type 1 diabetes and to reverse new-onset disease.RESEARCH DESIGN AND METHODS—Microspheres carrying antisense oligonucleoti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1059a0441eb0a4a08cb6c6e1660ae581
https://doi.org/10.2337/db07-0507
https://doi.org/10.2337/db07-0507
Publikováno v:
The Journal of Immunology. 173:4331-4341
Phenotypically “immature” dendritic cells (DCs), defined by low cell surface CD40, CD80, and CD86 can elicit host immune suppression in allotransplantation and autoimmunity. Herein, we report the most direct means of achieving phenotypic immaturi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a314cee1ecca31570f859caba91e8cc
https://doi.org/10.4049/jimmunol.173.7.4331
https://doi.org/10.4049/jimmunol.173.7.4331
Autor:
S Beckebaum, Theresa L. Whiteside, John J. Fung, Jo Harnaha, Donna B. Stolz, Lina Lu, Vito R. Cicinnati, Angus W. Thomson, Jan Müller-Berghaus, C. Andrew Bonham, Grzegorz Dworacki
Publikováno v:
Clinical Immunology. 104:138-150
Dendritic cells (DCs) induce and regulate T-cell-mediated immune responses. Circulating precursor (p)DC1 and pDC2 from patients with chronic hepatitis B virus (HBV) infection were quantified by flow cytometry. To assess their function, DC1 were cultu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f0805814230a03a7a60900c6715086f
https://doi.org/10.1006/clim.2002.5245
https://doi.org/10.1006/clim.2002.5245
Publikováno v:
Transplantation Proceedings. 36:1592-1594
Administration of donor-derived immature dendritic cells (DC) treated with NF-kappaB oligodeoxyribonucleotides (ODN) prevents allograft rejection. We attempted to explore the use of recipient-derived DC pulsed with donor antigens, in which the donor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d148103d8d822c97157aba118015977
https://doi.org/10.1016/j.transproceed.2004.04.099
https://doi.org/10.1016/j.transproceed.2004.04.099
Autor:
Jo Harnaha, Antonella D'Anneo, Brett E. Phillips, C. Engman, Nick Giannoukakis, Massimo Trucco, Valentina Di Caro
Publikováno v:
Immunologic research. 50(2-3)
Modulating PI3K at different stages of dendritic cells (DC) generation could be a novel means to balance the generation of immunosuppressive versus immunostimulatory DC. We show that PI3K inhibition during mouse DC generation in vitro results in cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f716f2770999a88f5ebe145b989830ae
https://pubmed.ncbi.nlm.nih.gov/21476100
https://pubmed.ncbi.nlm.nih.gov/21476100
Autor:
Massimo Trucco, Nick Giannoukakis, Robert Lakomy, C. Engman, Jo Harnaha, Brett E. Phillips, Antonella D'Anneo, V. Di Caro, A. Styche
Publikováno v:
Clinical and experimental immunology. 165(1)
We have identified a novel interleukin (IL)-7-responsive T cell population [forkhead box P3 (FoxP3(+) ) CD4(+) CD25(+) CD127(+) ] that is comparably functionally suppressive to conventional FoxP3(+) CD4(+) CD25(+) regulatory T cells (T(regs) ). Altho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc4cc51dfd16b0f3fbc47163df31b772
https://pubmed.ncbi.nlm.nih.gov/21413939
https://pubmed.ncbi.nlm.nih.gov/21413939
Publikováno v:
Transplantation. 50:554-557
Cardiac transplantation between inbred rat strains that differ for weak histocompatibility antigens is associated with the development of arteriosclerosis in the arteries of the donor graft myocardium. The lesions are seen in donor/recipient pairs th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3134bf3978e117491c4dc2d04c9dd27f
https://doi.org/10.1097/00007890-199010000-00004
https://doi.org/10.1097/00007890-199010000-00004