Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Jo G R De Mey"'
Autor:
Mahmoud H Elbatreek, Sepideh Sadegh, Elisa Anastasi, Emre Guney, Cristian Nogales, Tim Kacprowski, Ahmed A Hassan, Andreas Teubner, Po-Hsun Huang, Chien-Yi Hsu, Paul M H Schiffers, Ger M Janssen, Pamela W M Kleikers, Anil Wipat, Jan Baumbach, Jo G R De Mey, Harald H H W Schmidt
Publikováno v:
PLoS Biology, Vol 18, Iss 11, p e3000885 (2020)
Hypertension is the most important cause of death and disability in the elderly. In 9 out of 10 cases, the molecular cause, however, is unknown. One mechanistic hypothesis involves impaired endothelium-dependent vasodilation through reactive oxygen s
Externí odkaz:
https://doaj.org/article/59e3c69f9059443b811c06990062c088
Autor:
Atlanta G I M Elie, Maria Bloksgaard, Wai Y Sun, Kangmin Yang, Andy W C Man, Aimin Xu, Akhmadjon Irmukhamedov, Lars P Riber, Yu Wang, Jo G R De Mey
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0206802 (2018)
BACKGROUND:The pericardial fluid may be representative of the interstitium of the heart. The aim of this study was to discriminate in cardiovascular disease patients between adipocytokines that are produced locally by the heart and those supplied by
Externí odkaz:
https://doaj.org/article/95212b621a70419fb54eacf015221939
Autor:
Atlanta G I M Elie, Pia S Jensen, Katrine D Nissen, Ilvy M E Geraets, Aimin Xu, Erfei Song, Maria L Hansen, Akhmadjon Irmukhamedov, Lars M Rasmussen, Yu Wang, Jo G R De Mey
Publikováno v:
PLoS ONE, Vol 11, Iss 5, p e0154693 (2016)
AIM:Obesity and especially hypertrophy of epicardial adipose tissue accelerate coronary atherogenesis. We aimed at comparing levels of inflammatory and atherogenic hormones from adipose tissue in the pericardial fluid and circulation of cardiovascula
Externí odkaz:
https://doaj.org/article/65a407adbd654c258c1172ec19e44c0f
Autor:
Ramesh Chennupati, Merlijn J P M T Meens, Vincent Marion, Ben J Janssen, Wouter H Lamers, Jo G R De Mey, S Eleonore Köhler
Publikováno v:
PLoS ONE, Vol 9, Iss 7, p e102264 (2014)
Argininosuccinate synthetase (ASS) is essential for recycling L-citrulline, the by-product of NO synthase (NOS), to the NOS substrate L-arginine. Here, we assessed whether disturbed arginine resynthesis modulates endothelium-dependent vasodilatation
Externí odkaz:
https://doaj.org/article/84224269fcdb4318b5c33f291ce9fdb4
Autor:
Marina A Aleksinskaya, Ernst E H van Faassen, Jelly Nelissen, Ben J A Janssen, Jo G R De Mey, Roeland Hanemaaijer, Ton Rabelink, Anton Jan van Zonneveld
Publikováno v:
PLoS ONE, Vol 8, Iss 3, p e57761 (2013)
Nitric oxide (NO) has been implicated in matrix metallopeptidase 9 (MMP9)-dependent mobilization of hematopoietic stem and progenitor cells from bone marrow (BM). However, direct measurement of NO in the BM remained elusive due to its low in situ con
Externí odkaz:
https://doaj.org/article/f5783a14b1194100aa250447e93a484b
Autor:
Jeroen van den Akker, Ed VanBavel, Remon van Geel, Hanke L Matlung, Bilge Guvenc Tuna, George M C Janssen, Peter A van Veelen, Wilbert C Boelens, Jo G R De Mey, Erik N T P Bakker
Publikováno v:
PLoS ONE, Vol 6, Iss 8, p e23067 (2011)
While inward remodeling of small arteries in response to low blood flow, hypertension, and chronic vasoconstriction depends on type 2 transglutaminase (TG2), the mechanisms of action have remained unresolved. We studied the regulation of TG2 activity
Externí odkaz:
https://doaj.org/article/25f4718461c746d789739fa08ef99995
Autor:
Léon J A Spijkers, Rob F P van den Akker, Ben J A Janssen, Jacques J Debets, Jo G R De Mey, Erik S G Stroes, Bert-Jan H van den Born, Dayanjan S Wijesinghe, Charles E Chalfant, Luke MacAleese, Gert B Eijkel, Ron M A Heeren, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e21817 (2011)
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. As sphingolipids have been implicated in both the regulation of vascular contractility and growth, we investigated whether sphingolipid biology is alte
Externí odkaz:
https://doaj.org/article/7ea95473f792457ab3148a3baa0d7cd5
Autor:
Léon J A Spijkers, Ben J A Janssen, Jelly Nelissen, Merlijn J P M T Meens, Dayanjan Wijesinghe, Charles E Chalfant, Jo G R De Mey, Astrid E Alewijnse, Stephan L M Peters
Publikováno v:
PLoS ONE, Vol 6, Iss 12, p e29222 (2011)
We have previously shown that essential hypertension in humans and spontaneously hypertensive rats (SHR), is associated with increased levels of ceramide and marked alterations in sphingolipid biology. Pharmacological elevation of ceramide in isolate
Externí odkaz:
https://doaj.org/article/46004c2b269246d28a6a3d335037f686
Autor:
Merlijn J P M T Meens, Matthijs G Compeer, Tilman M Hackeng, Marc A van Zandvoort, Ben J A Janssen, Jo G R De Mey
Publikováno v:
PLoS ONE, Vol 5, Iss 6, p e10917 (2010)
BACKGROUND: Endothelin-1 (ET-1), a long-acting paracrine mediator, is implicated in cardiovascular diseases but clinical trials with ET-receptor antagonists were not successful in some areas. We tested whether the quasi-irreversible receptor-binding
Externí odkaz:
https://doaj.org/article/362b3f3584494c208b7774510d6e5d4f
Publikováno v:
Aalkjaer, C, Nilsson, H & De Mey, J G R 2021, ' Sympathetic and sensory-motor nerves in peripheral small arteries ', Physiological Reviews, vol. 101, no. 2, pp. 495-544 . https://doi.org/10.1152/physrev.00007.2020
Small arteries, which play important roles in controlling blood flow, blood pressure, and capillary pressure, are under nervous influence. Their innervation is predominantly sympathetic and sensory motor in nature, and while some arteries are densely
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6004f1bb613d1f1a9353f7e4a54633ed
https://doi.org/10.1152/physrev.00007.2020
https://doi.org/10.1152/physrev.00007.2020